Q27457 (Q27457_BRUPA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names	Submitted name: Microfilarial chitinase EMBL AAC47324.1 EC=3.2.1.14 EMBL AAC47324.1
Organism	Brugia pahangi (Filarial nematode worm) EMBL AAC47324.1
Taxonomic identifier	6280 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Nematoda › Chromadorea › Spirurida › Filarioidea › Onchocercidae › Brugia

Protein attributes

Sequence length	454 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the glycosyl hydrolase 18 family. RuleBase RU004453

Ontologies

Keywords
Molecular function	Glycosidase RuleBase RU000489 EMBL AAC47324.1 Hydrolase
Gene Ontology (GO)
Biological process	chitin catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	extracellular region Inferred from electronic annotation. Source: InterPro
Molecular function	cation binding Inferred from electronic annotation. Source: InterPro chitin binding Inferred from electronic annotation. Source: InterPro chitinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL AAC47324.1
	Non-terminal residue	454	1	EMBL AAC47324.1

Sequences

	Sequence		Length	Mass (Da)
	Q27457 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 8A84323A6EC8C027	FASTA	454	50,151
	10 20 30 40 50 60 LGDSKAFEWN DEDTPEKKGM YSAVTKLRET NPGLKVLLSY GGYNFGSAIF TGIAKSAQKT 70 80 90 100 110 120 ERFIKSAIAF LRKNNFDGFD LDWEYPVGVA EEHAKLVEAM KTAFVEEAKT SGKQRLLLTA 130 140 150 160 170 180 AVSAGKGTID GSYNVESLGK NFDLLFLMSY DLHGSWEKNV DLHGKLHPTK GEVSGIGIFN 190 200 210 220 230 240 TEFAADYWAS KGMPKQKIII GIPMYAQGWT LDNPSETAIG AAASRPSSAS KTNPAGGTAS 250 260 270 280 290 300 YWEICKYLKE GGKETIHQEG VGAYMVKGDQ WYGYDNEETI RIKMKWLKEK GYGGAFIWAL 310 320 330 340 350 360 DFDDFTGKSC GKGPYPLLNA ISSELEGESE NPEITTEEPS ITETEAYDTD ETEETSETEA 370 380 390 400 410 420 YDTDETEETS ETEAYDTDET EETSETEATT YDTDETEGQE CPERDGLFPH PTDCHLFIHC 430 440 450 ANNIAHVKQC PATTFFNDAI KVCDHMTNAP DTCI

References

[1]	"Transmission-blocking antibodies recognize microfilarial chitinase in brugian lymphatic filariasis." Fuhrman J.A., Lane W.S., Smith R.F., Piessens W.F., Perler F.B. Proc. Natl. Acad. Sci. U.S.A. 89:1548-1552(1992) [PubMed: 1542646] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[2]	"Discrete transcripts encode multiple chitinase isoforms in Brugian microfilariae." Arnold K., Venegas A., Houseweart C., Fuhrman J.A. Mol. Biochem. Parasitol. 80:149-158(1996) [PubMed: 8892292] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U59690 mRNA. Translation: AAC47324.1.
3D structure databases
HSSP	HSSP built from PDB template 1LG2 based on UniProtKB Q13231.
ProteinModelPortal	Q27457.
ModBase	Search...
Protein family/group databases
CAZy	CBM14. Carbohydrate-Binding Module Family 14. GH18. Glycoside Hydrolase Family 18.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR002557. Chitin-bd_dom. IPR011583. Chitinase_II. IPR001223. Glyco_hydro18cat. IPR001579. Glyco_hydro_18_chit_AS. IPR013781. Glyco_hydro_subgr_catalytic. IPR017853. Glycoside_hydrolase_SF. [Graphical view]
Gene3D	G3DSA:2.170.140.10. Chitin-bd_dom. 1 hit. G3DSA:3.20.20.80. Glyco_hydro_cat. 2 hits.
Pfam	PF01607. CBM_14. 1 hit. PF00704. Glyco_hydro_18. 1 hit. [Graphical view]
SMART	SM00494. ChtBD2. 1 hit. SM00636. Glyco_18. 1 hit. [Graphical view]
SUPFAM	SSF57625. Chitin_bind_PerA. 1 hit. SSF51445. Glyco_hydro_cat. 1 hit.
PROSITE	PS50940. CHIT_BIND_II. 1 hit. PS01095. CHITINASE_18. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q27457_BRUPA

Accession

Primary (citable) accession number: Q27457

Entry history

Integrated into UniProtKB/TrEMBL:	November 1, 1996
Last sequence update:	November 1, 1996
Last modified:	May 31, 2011
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)