Reviewed, UniProtKB/Swiss-Prot Q27404 (ADH_DROLA)

Names and origin

Protein names

Recommended name:
    Alcohol dehydrogenase
    EC=1.1.1.1

Gene names

Name:	Adh1
Synonyms:	Adh-1
AND
Name:	Adh2
Synonyms:	Adh-2

Organism

Drosophila lacicola (Fruit fly)

Taxonomic identifier

40369 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila

Protein attributes

Sequence length	254 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	An alcohol + NAD+ = an aldehyde or ketone + NADH.
Subunit structure	Homodimer.
Sequence similarities	Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	cellular alcohol metabolic process Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	alcohol dehydrogenase activity Inferred from electronic annotation. Source: EC binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 254	254	Alcohol dehydrogenase		PRO_0000054470
Regions
	Nucleotide binding	10 – 33	24	NAD By similarity
Sites
	Active site	151	1	Proton acceptor By similarity
	Binding site	138	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q27404-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 2CC1A502F26F5A49	FASTA	254	27,536
	10 20 30 40 50 60 MAIANKNIIF VAGLGGIGLD TSREIVKSGP KNLVILDRID NPTAIAELKA INPKVTVTFY 70 80 90 100 110 120 PYDVTVPVAE TTKLLKTIFA QLKTVDLLIN GAGILDDHQI ERTIAVNFTG TVNTTTAIME 130 140 150 160 170 180 FWDKRKGGPG GVVANICSVT GFNAIYQVPV YSASKAAALS FTNSLARLAP ITGVTAYSIN 190 200 210 220 230 240 PGITRTPLVH KFNSWLDVEP RVGELLLEHP TQTTLECAQN FVKAIEANKN GAIWQLDLGQ 250 LIAVEWTKHW DSHI

References

[1]	"Molecular phylogeny and genome evolution in the Drosophila virilis species group: duplications of the alcohol dehydrogenase gene." Nurminsky D.I., Moriyama E.N., Lozovskaya E.R., Hartl D.L. Mol. Biol. Evol. 13:132-149(1996) [PubMed: 8583887] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	U26840 Genomic DNA. Translation: AAB02626.1. U26841 Genomic DNA. Translation: AAB02627.1.
3D structure databases
HSSP	HSSP built from PDB template 1B16 based on UniProtKB P10807.
SMR	Q27404. Positions 1-254.
ModBase	Search...
Organism-specific databases
FlyBase	FBgn0013821. Dlac\Adh1. FBgn0013822. Dlac\Adh2.
Enzyme and pathway databases
BRENDA	1.1.1.1. 308768.
Family and domain databases
InterPro	IPR002198. DH_sc/Rdtase_SDR. IPR002425. Insect_ADH. IPR002424. Insect_AlcDH_fam. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR19410. ADH_short_C2. 1 hit.
Pfam	PF00106. adh_short. 1 hit. [Graphical view]
PRINTS	PR01168. ALCDHDRGNASE. PR01167. INSADHFAMILY. PR00080. SDRFAMILY.
PROSITE	PS00061. ADH_SHORT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ADH_DROLA

Accession

Primary (citable) accession number: Q27404

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	November 1, 1996
Last modified:	June 16, 2009
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Drosophila annotation project