Q27404 (ADH_DROLA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Alcohol dehydrogenase
EC=1.1.1.1

Gene names

Name:	Adh1
Synonyms:	Adh-1
AND
Name:	Adh2
Synonyms:	Adh-2

Organism

Drosophila lacicola (Fruit fly)

Taxonomic identifier

40369 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Eremoneura › Cyclorrhapha › Schizophora › Acalyptratae › Ephydroidea › Drosophilidae › Drosophilinae › Drosophilini › Drosophilina › Drosophiliti › Drosophila › Drosophila › virilis group

Protein attributes

Sequence length	254 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	An alcohol + NAD+ = an aldehyde or ketone + NADH.
Subunit structure	Homodimer.
Sequence similarities	Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological_process	alcohol metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	alcohol dehydrogenase (NAD) activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 254	254	Alcohol dehydrogenase		PRO_0000054470
Regions
	Nucleotide binding	10 – 33	24	NAD By similarity
Sites
	Active site	151	1	Proton acceptor By similarity
	Binding site	138	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q27404 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 2CC1A502F26F5A49	FASTA	254	27,536
	10 20 30 40 50 60 MAIANKNIIF VAGLGGIGLD TSREIVKSGP KNLVILDRID NPTAIAELKA INPKVTVTFY 70 80 90 100 110 120 PYDVTVPVAE TTKLLKTIFA QLKTVDLLIN GAGILDDHQI ERTIAVNFTG TVNTTTAIME 130 140 150 160 170 180 FWDKRKGGPG GVVANICSVT GFNAIYQVPV YSASKAAALS FTNSLARLAP ITGVTAYSIN 190 200 210 220 230 240 PGITRTPLVH KFNSWLDVEP RVGELLLEHP TQTTLECAQN FVKAIEANKN GAIWQLDLGQ 250 LIAVEWTKHW DSHI

References

[1]	"Molecular phylogeny and genome evolution in the Drosophila virilis species group: duplications of the alcohol dehydrogenase gene." Nurminsky D.I., Moriyama E.N., Lozovskaya E.R., Hartl D.L. Mol. Biol. Evol. 13:132-149(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U26840 Genomic DNA. Translation: AAB02626.1. U26841 Genomic DNA. Translation: AAB02627.1.
3D structure databases
ProteinModelPortal	Q27404.
SMR	Q27404. Positions 1-254.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
FlyBase	FBgn0013821. Dlac\Adh1. FBgn0013822. Dlac\Adh2.
Family and domain databases
Gene3D	3.40.50.720. 1 hit.
InterPro	IPR002425. ADH_Drosophila-type. IPR002424. ADH_insect. IPR002198. DH_sc/Rdtase_SDR. IPR016040. NAD(P)-bd_dom. IPR020904. Sc_DH/Rdtase_CS. [Graphical view]
Pfam	PF00106. adh_short. 1 hit. [Graphical view]
PRINTS	PR01168. ALCDHDRGNASE. PR01167. INSADHFAMILY. PR00080. SDRFAMILY.
PROSITE	PS00061. ADH_SHORT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ADH_DROLA

Accession

Primary (citable) accession number: Q27404

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	November 1, 1996
Last modified:	May 29, 2013
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Drosophila annotation project