Q27377 (OB10_DROME) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative odorant-binding protein A10

Alternative name(s):
Antennal protein 10
OS-D protein

Gene names

Name:	a10
Synonyms:	OS-D
ORF Names:	CG6642

Organism

Drosophila melanogaster (Fruit fly)

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	155 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Secreted Potential.
Tissue specificity	Antenna. In the third antennal segment. Expressed in sencilla coeloconica.
Developmental stage	Expressed in adult but not in larval olfactory organs.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
eIF-4E	P48598-1	1	EBI-109998,EBI-198595

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 29	29	Potential
	Chain	30 – 155	126	Putative odorant-binding protein A10		PRO_0000021874
Experimental info
	Sequence conflict	13	1	V → F in AAC46473. Ref.1
	Sequence conflict	13	1	V → F in AAA21358. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q27377 [UniParc]. Last modified July 24, 2007. Version 2. Checksum: A10345771C338261	FASTA	155	17,780
	10 20 30 40 50 60 MGQPGFRRAI GHVSLVVALM CTTCFQVEGL PHPPATSPSP MMERMVEQAY DDKFDNVDLD 70 80 90 100 110 120 EILNQERLLI NYIKCLEGTG PCTPDAKMLK EILPDAIQTD CTKCTEKQRY GAEKVTRHLI 130 140 150 DNRPTDWERL EKIYDPEGTY RIKYQEMKSK ANEEP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Members of a family of Drosophila putative odorant-binding proteins are expressed in different subsets of olfactory hairs." Pikielny C.W., Hasan G., Rouyer F., Rosbash M. Neuron 12:35-49(1994) [PubMed: 7545907] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Canton-S. Tissue: Antenna.
[2]	"Putative Drosophila pheromone-binding proteins expressed in a subregion of the olfactory system." McKenna M.P., Hekmat-Scafe D.S., Gaines P., Carlson J.R. J. Biol. Chem. 269:16340-16347(1994) [PubMed: 8206941] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: CS-5. Tissue: Antenna.
[3]	"Genome and EST analyses and expression of a gene family with putative functions in insect chemoreception." Zhou J.-J., Kan Y., Antoniw J., Pickett J.A., Field L.M. Chem. Senses 31:453-465(2006) [PubMed: 16581978] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[5]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: GENOME REANNOTATION. Strain: Berkeley.
[6]	Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Pacleb J.M., Park S., Wan K.H., Yu C., Celniker S.E. Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Berkeley.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U05244 mRNA. Translation: AAC46473.1. U02546 mRNA. Translation: AAA21358.1. AJ973480 mRNA. Translation: CAJ01527.1. AE014296 Genomic DNA. Translation: AAF49381.1. BT025814 mRNA. Translation: ABF85714.1.
RefSeq	NP_524121.2. NM_079397.2.
UniGene	Dm.2533.
3D structure databases
ProteinModelPortal	Q27377.
SMR	Q27377. Positions 47-154.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q27377. 1 interaction.
MINT	MINT-883113.
STRING	Q27377.
Proteomic databases
PRIDE	Q27377.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0075290; FBpp0075050; FBgn0011293.
GeneID	39906.
KEGG	dme:Dmel_CG6642.
NMPDR	fig|7227.3.peg.10269.
Organism-specific databases
CTD	39906.
FlyBase	FBgn0011293. a10.
Phylogenomic databases
eggNOG	inNOG11471.
GeneTree	EMGT00050000006756.
InParanoid	Q27377.
OMA	SKANEEP.
OrthoDB	EOG4H18C1.
PhylomeDB	Q27377.
Gene expression databases
Bgee	Q27377.
GermOnline	CG6642. Drosophila melanogaster.
Family and domain databases
InterPro	IPR005055. OS_D_PhBP. [Graphical view]
Gene3D	G3DSA:1.10.2080.10. OS_D_PhBP. 1 hit.
PANTHER	PTHR11257. OS_D_PhBP. 1 hit.
Pfam	PF03392. OS-D. 1 hit. [Graphical view]
SUPFAM	SSF100910. OS_D_PhBP. 1 hit.
ProtoNet	Search...
Other
NextBio	816031.

Entry information

Entry name

OB10_DROME

Accession

Primary (citable) accession number: Q27377
Secondary accession number(s): Q3LB26, Q9VVD1

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	July 24, 2007
Last modified:	January 25, 2012
This is version 80 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Drosophila annotation project