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Protein

Protein sine oculis

Gene

so

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Required for visual system development. May transcriptionally regulate genes necessary for optic lobe invagination and Bolwig's nerve formation.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi218 – 277HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

  • sequence-specific DNA binding Source: FlyBase
  • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding Source: FlyBase
  • transcription factor activity, sequence-specific DNA binding Source: FlyBase
  • transcription factor binding Source: FlyBase

GO - Biological processi

  • Bolwig's organ morphogenesis Source: FlyBase
  • circadian rhythm Source: FlyBase
  • compound eye development Source: FlyBase
  • compound eye morphogenesis Source: FlyBase
  • entrainment of circadian clock Source: FlyBase
  • eye-antennal disc morphogenesis Source: FlyBase
  • glial cell migration Source: FlyBase
  • optic lobe placode formation Source: FlyBase
  • positive regulation of transcription from RNA polymerase II promoter Source: FlyBase
  • ring gland development Source: FlyBase
  • spermatogenesis Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

SignaLinkiQ27350.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein sine oculis
Gene namesi
Name:so
ORF Names:CG11121
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0003460. so.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation1 Publication

GO - Cellular componenti

  • nucleus Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Flies specifically display visual defects. These range from reduced ocelli and ommatidia number in weak loss-of-function phenotypes to complete absence of compound eyes and bolwig's organ in more severe lethal phenotypes.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000493151 – 416Protein sine oculisAdd BLAST416

Proteomic databases

PaxDbiQ27350.
PRIDEiQ27350.

Expressioni

Tissue specificityi

In developing embryos, expressed in the eye disk epithelium, bolwig's organ and the optic lobe primordium at areas of invagination. In adults, present in photoreceptor cells in the apical regions of the retina, and in optic lobes.1 Publication

Developmental stagei

In the eye imaginal disk, first expressed at the onset of the third instar and continues throughout this stage. Expression in the optic lobe primordium begins at stage 5 and disappears when invagination is completed (stage 12). Further expression is noted in optic lobe ganglia in late third instar.1 Publication

Gene expression databases

BgeeiFBgn0003460.
GenevisibleiQ27350. DM.

Interactioni

GO - Molecular functioni

  • transcription factor binding Source: FlyBase

Protein-protein interaction databases

BioGridi61542. 28 interactors.
DIPiDIP-18228N.
IntActiQ27350. 8 interactors.
MINTiMINT-302975.
STRINGi7227.FBpp0089177.

Structurei

3D structure databases

ProteinModelPortaliQ27350.
SMRiQ27350.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi42 – 47Poly-Asn6
Compositional biasi52 – 55Poly-Asn4
Compositional biasi80 – 85Poly-Gly6
Compositional biasi307 – 317Gln/His-rich (OPA repeat)Add BLAST11
Compositional biasi366 – 372Poly-Gly7
Compositional biasi375 – 379Poly-Ala5

Sequence similaritiesi

Belongs to the SIX/Sine oculis homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0775. Eukaryota.
ENOG410XRPB. LUCA.
GeneTreeiENSGT00540000070251.
InParanoidiQ27350.
KOiK15614.
OMAiNLDIMTH.
OrthoDBiEOG091G083I.
PhylomeDBiQ27350.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR031701. SIX1_SD.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF16878. SIX1_SD. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q27350-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLQHPATDFY DLAAANAAAV LTARHTPPYS PTGLSGSVAL HNNNNNNSST
60 70 80 90 100
SNNNNSTLDI MAHNGGGAGG GLHLNSSSNG GGGGGVVSGG GSGGRENLPS
110 120 130 140 150
FGFTQEQVAC VCEVLQQAGN IERLGRFLWS LPQCDKLQLN ESVLKAKAVV
160 170 180 190 200
AFHRGQYKEL YRLLEHHHFS AQNHAKLQAL WLKAHYVEAE KLRGRPLGAV
210 220 230 240 250
GKYRVRRKFP LPRTIWDGEE TSYCFKEKSR SVLRDWYSHN PYPSPREKRD
260 270 280 290 300
LAEATGLTTT QVSNWFKNRR QRDRAAEHKD GSTDKQHLDS SSDSEMEGSM
310 320 330 340 350
LPSQSAQHQQ QQQQQQHSPG NSSGNNNGLH QQQLQHVAAE QGLQHHPHQP
360 370 380 390 400
HPASNIANVA ATKSSGGGGG GGVSAAAAAQ MQMPPLTAAV AYSHLHSVMG
410
AMPMTAMYDM GEYQHL
Length:416
Mass (Da):45,025
Last modified:November 1, 1996 - v1
Checksum:i669E4BD95B857996
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S77459 mRNA. Translation: AAB34685.1.
L31626 mRNA. Translation: AAA21800.1.
AE013599 Genomic DNA. Translation: AAF59260.1.
BT029256 mRNA. Translation: ABK30893.1.
PIRiS50342.
RefSeqiNP_476733.1. NM_057385.5.
UniGeneiDm.4727.

Genome annotation databases

EnsemblMetazoaiFBtr0088970; FBpp0089177; FBgn0003460.
GeneIDi35662.
KEGGidme:Dmel_CG11121.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S77459 mRNA. Translation: AAB34685.1.
L31626 mRNA. Translation: AAA21800.1.
AE013599 Genomic DNA. Translation: AAF59260.1.
BT029256 mRNA. Translation: ABK30893.1.
PIRiS50342.
RefSeqiNP_476733.1. NM_057385.5.
UniGeneiDm.4727.

3D structure databases

ProteinModelPortaliQ27350.
SMRiQ27350.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi61542. 28 interactors.
DIPiDIP-18228N.
IntActiQ27350. 8 interactors.
MINTiMINT-302975.
STRINGi7227.FBpp0089177.

Proteomic databases

PaxDbiQ27350.
PRIDEiQ27350.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0088970; FBpp0089177; FBgn0003460.
GeneIDi35662.
KEGGidme:Dmel_CG11121.

Organism-specific databases

CTDi35662.
FlyBaseiFBgn0003460. so.

Phylogenomic databases

eggNOGiKOG0775. Eukaryota.
ENOG410XRPB. LUCA.
GeneTreeiENSGT00540000070251.
InParanoidiQ27350.
KOiK15614.
OMAiNLDIMTH.
OrthoDBiEOG091G083I.
PhylomeDBiQ27350.

Enzyme and pathway databases

SignaLinkiQ27350.

Miscellaneous databases

GenomeRNAii35662.
PROiQ27350.

Gene expression databases

BgeeiFBgn0003460.
GenevisibleiQ27350. DM.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR031701. SIX1_SD.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF16878. SIX1_SD. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSO_DROME
AccessioniPrimary (citable) accession number: Q27350
Secondary accession number(s): A0AVT8, Q9V4L0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 142 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.