Reviewed, UniProtKB/Swiss-Prot Q27350 (SO_DROME)

Names and origin

Protein names

Recommended name:
    Protein sine oculis

Gene names

Name:	so
ORF Names:	CG11121

Organism

Drosophila melanogaster (Fruit fly) [Complete proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	416 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Required for visual system development. May transcriptionally regulate genes necessary for optic lobe invagination and Bolwig's nerve formation.
Subcellular location	Nucleus.
Tissue specificity	In developing embryos, expressed in the eye disk epithelium, bolwig's organ and the optic lobe primordium at areas of invagination. In adults, present in photoreceptor cells in the apical regions of the retina, and in optic lobes.
Developmental stage	In the eye imaginal disk, first expressed at the onset of the third instar and continues throughout this stage. Expression in the optic lobe primordium begins at stage 5 and disappears when invagination is completed (stage 12). Further expression is noted in optic lobe ganglia in late third instar.
Miscellaneous	Flies lacking so specifically display visual defects. These range from reduced ocelli and ommatidia number in weak loss-of-function phenotypes to complete absence of compound eyes and bolwig's organ in more severe lethal phenotypes.
Sequence similarities	Belongs to the SIX/Sine oculis homeobox family. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	Bolwig's organ morphogenesis Inferred from mutant phenotype. Source: FlyBase compound eye morphogenesis Inferred from mutant phenotype. Source: FlyBase entrainment of circadian clock Inferred from mutant phenotype. Source: FlyBase eye-antennal disc morphogenesis Traceable author statement. Source: FlyBase glial cell migration Inferred from mutant phenotype. Source: FlyBase optic lobe placode formation Inferred from mutant phenotype. Source: FlyBase regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro spermatogenesis Inferred from mutant phenotype. Source: FlyBase
Cellular component	nucleus Inferred from electronic annotation. Source: InterPro
Molecular function	protein binding Inferred from physical interaction. Source: IntAct sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
	Q9VRP2	1	EBI-161504,EBI-156155
EG:52C10.1	O96841	1	EBI-161504,EBI-156192
eya	Q05201-2	1	EBI-161504,EBI-209775
gro	P16371	1	EBI-161504,EBI-153866
Sobp	Q95TY2	1	EBI-161504,EBI-164333
VhaAC39	Q9W4P5	1	EBI-161504,EBI-179683

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 416	416	Protein sine oculis		PRO_0000049315
Regions
	DNA binding	218 – 277	60	Homeobox
	Compositional bias	42 – 47	6	Poly-Asn
	Compositional bias	52 – 55	4	Poly-Asn
	Compositional bias	80 – 85	6	Poly-Gly
	Compositional bias	307 – 317	11	Gln/His-rich (OPA repeat)
	Compositional bias	366 – 372	7	Poly-Gly
	Compositional bias	375 – 379	5	Poly-Ala

Sequences

	Sequence		Length	Mass (Da)
	Q27350-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 669E4BD95B857996	FASTA	416	45,025
	10 20 30 40 50 60 MLQHPATDFY DLAAANAAAV LTARHTPPYS PTGLSGSVAL HNNNNNNSST SNNNNSTLDI 70 80 90 100 110 120 MAHNGGGAGG GLHLNSSSNG GGGGGVVSGG GSGGRENLPS FGFTQEQVAC VCEVLQQAGN 130 140 150 160 170 180 IERLGRFLWS LPQCDKLQLN ESVLKAKAVV AFHRGQYKEL YRLLEHHHFS AQNHAKLQAL 190 200 210 220 230 240 WLKAHYVEAE KLRGRPLGAV GKYRVRRKFP LPRTIWDGEE TSYCFKEKSR SVLRDWYSHN 250 260 270 280 290 300 PYPSPREKRD LAEATGLTTT QVSNWFKNRR QRDRAAEHKD GSTDKQHLDS SSDSEMEGSM 310 320 330 340 350 360 LPSQSAQHQQ QQQQQQHSPG NSSGNNNGLH QQQLQHVAAE QGLQHHPHQP HPASNIANVA 370 380 390 400 410 ATKSSGGGGG GGVSAAAAAQ MQMPPLTAAV AYSHLHSVMG AMPMTAMYDM GEYQHL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sine oculis is a homeobox gene required for Drosophila visual system development." Serikaku M.A., O'Tousa J.E. Genetics 138:1137-1150(1994) [PubMed: 7896096] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION. Tissue: Head.
[2]	"The Drosophila sine oculis locus encodes a homeodomain-containing protein required for the development of the entire visual system." Cheyette B.N.R., Green P.J., Martin K., Garren H., Hartenstein V., Zipursky S.L. Neuron 12:977-996(1994) [PubMed: 7910468] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE. Tissue: Embryo and Eye imaginal disk.
[3]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[4]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: GENOME REANNOTATION.
[5]	Stapleton M., Carlson J.W., Frise E., Kapadia B., Park S., Wan K.H., Yu C., Celniker S.E. Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Berkeley.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	S77459 mRNA. Translation: AAB34685.1. L31626 mRNA. Translation: AAA21800.1. AE013599 Genomic DNA. Translation: AAF59260.1. BT029256 mRNA. Translation: ABK30893.1.
PIR	S50342.
RefSeq	NP_476733.1.
UniGene	Dm.4727
3D structure databases
HSSP	HSSP built from PDB template 1DU6 based on UniProtKB P41778.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:18228N.
IntAct	Q27350.
Genome annotation databases
Ensembl	CG11121. Drosophila melanogaster. [Contig view]
GeneID	35662.
KEGG	dme:Dmel_CG11121.
NMPDR	fig|7227.3.peg.3635.
Organism-specific databases
FlyBase	FBgn0003460. so.
Phylogenomic databases
HOGENOM	Q27350.
Enzyme and pathway databases
BioCyc	DMEL-XXX-02:DMEL-XXX-02-003199-MON.
Family and domain databases
InterPro	IPR001356. Homeobox. IPR012287. Homeodomain-rel. IPR000047. HTH_lambrepressr. [Graphical view]
Gene3D	G3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00024. HOMEOBOX. PR00031. HTHREPRESSR.
ProDom	PD000010. Homeobox. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00389. HOX. 1 hit. [Graphical view]
PROSITE	PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	794611.

Entry information

Entry name

SO_DROME

Accession

Primary (citable) accession number: Q27350
Secondary accession number(s): A0AVT8, Q9V4L0

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	November 25, 2008
This is version 78 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Drosophila annotation project