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Protein

Tyrosine-protein kinase Drl

Gene

drl

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Probable coreceptor of Wnt proteins. Involved in neuronal pathway recognition and ventral muscle attachment site selection. Non-vital for development. May be part of a signal transduction cascade involved in learning and possibly memory.3 Publications

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei371ATPPROSITE-ProRule annotation1
Active sitei468Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi349 – 357ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protein heterodimerization activity Source: FlyBase
  • protein homodimerization activity Source: FlyBase
  • protein kinase activity Source: InterPro
  • protein kinase binding Source: FlyBase
  • Wnt-activated receptor activity Source: ParkinsonsUK-UCL
  • Wnt-protein binding Source: FlyBase

GO - Biological processi

  • axon guidance Source: UniProtKB
  • axon midline choice point recognition Source: FlyBase
  • chemorepulsion of axon Source: FlyBase
  • dendrite guidance Source: FlyBase
  • determination of muscle attachment site Source: FlyBase
  • haltere development Source: FlyBase
  • learning or memory Source: UniProtKB
  • memory Source: FlyBase
  • muscle attachment Source: UniProtKB
  • mushroom body development Source: ParkinsonsUK-UCL
  • olfactory learning Source: FlyBase
  • salivary gland morphogenesis Source: FlyBase
  • signal transduction Source: UniProtKB
  • synapse assembly Source: ParkinsonsUK-UCL
  • Wnt signaling pathway Source: ParkinsonsUK-UCL

Keywordsi

Molecular functionDevelopmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase
Biological processWnt signaling pathway
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.1 1994
SignaLinkiQ27324

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinase Drl (EC:2.7.10.1)
Alternative name(s):
Protein derailed
Gene namesi
Name:drl
Synonyms:lio
ORF Names:CG17348
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi

Organism-specific databases

FlyBaseiFBgn0015380 drl

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 242ExtracellularSequence analysisAdd BLAST222
Transmembranei243 – 263HelicalSequence analysisAdd BLAST21
Topological domaini264 – 610CytoplasmicSequence analysisAdd BLAST347

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000002446621 – 610Tyrosine-protein kinase DrlAdd BLAST590

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi63N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi99N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi143N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei498Phosphotyrosine; by autocatalysisBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ27324
PRIDEiQ27324

Expressioni

Tissue specificityi

In the embryonic abdominal hemisegment, expression is restricted to cell body, axon and growth cone of a cluster of 20 ventral nerve cord interneurons. During muscle growth and attachment events in the embryonic abdominal hemisegment, expression is in somatic muscle fibers 21-23 at 10-13 hours and 2 patches of approximately 15 neighboring epidermal cells (dorsal and ventral attachment sites) at 6-13 hours.2 Publications

Gene expression databases

BgeeiFBgn0015380
ExpressionAtlasiQ27324 baseline and differential
GenevisibleiQ27324 DM

Interactioni

GO - Molecular functioni

  • protein heterodimerization activity Source: FlyBase
  • protein homodimerization activity Source: FlyBase
  • protein kinase binding Source: FlyBase
  • Wnt-protein binding Source: FlyBase

Protein-protein interaction databases

BioGridi69001, 17 interactors
DIPiDIP-22284N
IntActiQ27324, 1 interactor
STRINGi7227.FBpp0303242

Structurei

3D structure databases

ProteinModelPortaliQ27324
SMRiQ27324
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 155WIFPROSITE-ProRule annotationCuratedAdd BLAST132
Domaini343 – 606Protein kinasePROSITE-ProRule annotationAdd BLAST264

Domaini

The extracellular WIF domain is responsible for Wnt binding.By similarity

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1024 Eukaryota
ENOG410XSKI LUCA
GeneTreeiENSGT00810000125384
InParanoidiQ27324
KOiK05128
OMAiEYKLGFQ
OrthoDBiEOG091G0353
PhylomeDBiQ27324

Family and domain databases

Gene3Di2.60.40.2170, 1 hit
InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008266 Tyr_kinase_AS
IPR003306 WIF
IPR038677 WIF_sf
PfamiView protein in Pfam
PF07714 Pkinase_Tyr, 1 hit
PF02019 WIF, 1 hit
PRINTSiPR00109 TYRKINASE
ProDomiView protein in ProDom or Entries sharing at least one domain
PD013948 WIF, 1 hit
SMARTiView protein in SMART
SM00469 WIF, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
PS50814 WIF, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q27324-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPNLLTIGL LLTLIASGQA HLNIFLNLHE VLRLIGVSAE LYYVREGAIN
60 70 80 90 100
DYALNFAVPV PANISDVTFT WQSLVDHPLP YSINIATSDT EVLPRPILNI
110 120 130 140 150
SRIGDVPVEP QTWGIALKCS GTRNAEVTVT INVEVILDRA TNNNTNLIFK
160 170 180 190 200
RKKICLREEQ DSAHEEYDDD DLDLLQTARK GHGGDIHYVD RNDEHVVANG
210 220 230 240 250
HQAPEKQRPV VTESPVGRGN SGGSKRDFDP MLRENLVPPA SGLVTLIVGG
260 270 280 290 300
ILALVLVSTL ILIAYCAKGP SKRHPSNGVH LIKTSSFQRL PTISSTAHNS
310 320 330 340 350
IYVCPSTITP TYATLTRPFR EYEHEPEEFN RRLQELTVQK CRVRLSCLVQ
360 370 380 390 400
EGNFGRIYRG TYNDCQEVLV KTVAQHASQL QVNLLLQESM MLYEASHPNV
410 420 430 440 450
LSVLGISIED YATPFVLYAA TGSVRNLKSF LQDPSYARSV TTIQTVLMGS
460 470 480 490 500
QLAMAMEHLH NHGVIHKDIA ARNCVIDDQL RVKLTDSALS RDLFPGDYNS
510 520 530 540 550
LGDGEYRPIK WLSLEALQKS HYNEGSDVWS FGVLMWEMCT LGKLPYAEID
560 570 580 590 600
PYEMEHYLKD GYRLAQPFNC PDELFTIMAY CWASMPAERP SFSQLQICLS
610
EFHTQITRYV
Length:610
Mass (Da):68,312
Last modified:November 1, 1996 - v1
Checksum:i728A3F272DAED4BE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U36584 mRNA Translation: AAA79949.1
L47260 mRNA Translation: AAA75347.1
AE014134 Genomic DNA Translation: AAF53776.1
AY051852 mRNA Translation: AAK93276.1
AF147883 Genomic DNA Translation: AAD41343.1
PIRiS58885
RefSeqiNP_477139.1, NM_057791.4
UniGeneiDm.4108

Genome annotation databases

EnsemblMetazoaiFBtr0081195; FBpp0080736; FBgn0015380
FBtr0330209; FBpp0303242; FBgn0015380
GeneIDi44355
KEGGidme:Dmel_CG17348
UCSCiCG17348-RA d. melanogaster

Entry informationi

Entry nameiRYK1_DROME
AccessioniPrimary (citable) accession number: Q27324
Secondary accession number(s): Q9U9Y3, Q9VIY6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 27, 2003
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 165 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

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