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Protein

Tyrosine-protein kinase Drl

Gene

drl

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Probable coreceptor of Wnt proteins. Involved in neuronal pathway recognition and ventral muscle attachment site selection. Non-vital for development. May be part of a signal transduction cascade involved in learning and possibly memory.3 Publications

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei371ATPPROSITE-ProRule annotation1
Active sitei468Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi349 – 357ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protein heterodimerization activity Source: FlyBase
  • protein homodimerization activity Source: FlyBase
  • protein kinase activity Source: InterPro
  • protein kinase binding Source: FlyBase
  • Wnt-activated receptor activity Source: ParkinsonsUK-UCL
  • Wnt-protein binding Source: FlyBase

GO - Biological processi

  • axon guidance Source: UniProtKB
  • axon midline choice point recognition Source: FlyBase
  • chemorepulsion of axon Source: FlyBase
  • dendrite guidance Source: FlyBase
  • determination of muscle attachment site Source: FlyBase
  • haltere development Source: FlyBase
  • learning or memory Source: UniProtKB
  • memory Source: FlyBase
  • muscle attachment Source: UniProtKB
  • mushroom body development Source: ParkinsonsUK-UCL
  • negative regulation of Wnt signaling pathway Source: FlyBase
  • olfactory learning Source: FlyBase
  • regulation of glucose metabolic process Source: FlyBase
  • salivary gland morphogenesis Source: FlyBase
  • signal transduction Source: UniProtKB
  • synapse assembly Source: ParkinsonsUK-UCL
  • Wnt signaling pathway Source: ParkinsonsUK-UCL

Keywordsi

Molecular functionDevelopmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase
Biological processWnt signaling pathway
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.1. 1994.
SignaLinkiQ27324.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinase Drl (EC:2.7.10.1)
Alternative name(s):
Protein derailed
Gene namesi
Name:drl
Synonyms:lio
ORF Names:CG17348
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0015380. drl.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 242ExtracellularSequence analysisAdd BLAST222
Transmembranei243 – 263HelicalSequence analysisAdd BLAST21
Topological domaini264 – 610CytoplasmicSequence analysisAdd BLAST347

GO - Cellular componenti

  • axon Source: FlyBase
  • dendrite Source: FlyBase
  • integral component of plasma membrane Source: FlyBase
  • receptor complex Source: FlyBase

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000002446621 – 610Tyrosine-protein kinase DrlAdd BLAST590

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi63N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi99N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi143N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei498Phosphotyrosine; by autocatalysisBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ27324.
PRIDEiQ27324.

Expressioni

Tissue specificityi

In the embryonic abdominal hemisegment, expression is restricted to cell body, axon and growth cone of a cluster of 20 ventral nerve cord interneurons. During muscle growth and attachment events in the embryonic abdominal hemisegment, expression is in somatic muscle fibers 21-23 at 10-13 hours and 2 patches of approximately 15 neighboring epidermal cells (dorsal and ventral attachment sites) at 6-13 hours.2 Publications

Gene expression databases

BgeeiFBgn0015380.
ExpressionAtlasiQ27324. differential.
GenevisibleiQ27324. DM.

Interactioni

GO - Molecular functioni

  • protein heterodimerization activity Source: FlyBase
  • protein homodimerization activity Source: FlyBase
  • protein kinase binding Source: FlyBase
  • Wnt-protein binding Source: FlyBase

Protein-protein interaction databases

BioGridi69001. 10 interactors.
DIPiDIP-22284N.
IntActiQ27324. 1 interactor.
MINTiMINT-337834.
STRINGi7227.FBpp0303242.

Structurei

3D structure databases

ProteinModelPortaliQ27324.
SMRiQ27324.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 155WIFPROSITE-ProRule annotationCuratedAdd BLAST132
Domaini343 – 606Protein kinasePROSITE-ProRule annotationAdd BLAST264

Domaini

The extracellular WIF domain is responsible for Wnt binding.By similarity

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1024. Eukaryota.
ENOG410XSKI. LUCA.
GeneTreeiENSGT00810000125384.
InParanoidiQ27324.
KOiK05128.
OrthoDBiEOG091G0353.
PhylomeDBiQ27324.

Family and domain databases

InterProiView protein in InterPro
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR003306. WIF.
PfamiView protein in Pfam
PF07714. Pkinase_Tyr. 1 hit.
PF02019. WIF. 1 hit.
PRINTSiPR00109. TYRKINASE.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD013948. WIF. 1 hit.
SMARTiView protein in SMART
SM00469. WIF. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50814. WIF. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q27324-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPNLLTIGL LLTLIASGQA HLNIFLNLHE VLRLIGVSAE LYYVREGAIN
60 70 80 90 100
DYALNFAVPV PANISDVTFT WQSLVDHPLP YSINIATSDT EVLPRPILNI
110 120 130 140 150
SRIGDVPVEP QTWGIALKCS GTRNAEVTVT INVEVILDRA TNNNTNLIFK
160 170 180 190 200
RKKICLREEQ DSAHEEYDDD DLDLLQTARK GHGGDIHYVD RNDEHVVANG
210 220 230 240 250
HQAPEKQRPV VTESPVGRGN SGGSKRDFDP MLRENLVPPA SGLVTLIVGG
260 270 280 290 300
ILALVLVSTL ILIAYCAKGP SKRHPSNGVH LIKTSSFQRL PTISSTAHNS
310 320 330 340 350
IYVCPSTITP TYATLTRPFR EYEHEPEEFN RRLQELTVQK CRVRLSCLVQ
360 370 380 390 400
EGNFGRIYRG TYNDCQEVLV KTVAQHASQL QVNLLLQESM MLYEASHPNV
410 420 430 440 450
LSVLGISIED YATPFVLYAA TGSVRNLKSF LQDPSYARSV TTIQTVLMGS
460 470 480 490 500
QLAMAMEHLH NHGVIHKDIA ARNCVIDDQL RVKLTDSALS RDLFPGDYNS
510 520 530 540 550
LGDGEYRPIK WLSLEALQKS HYNEGSDVWS FGVLMWEMCT LGKLPYAEID
560 570 580 590 600
PYEMEHYLKD GYRLAQPFNC PDELFTIMAY CWASMPAERP SFSQLQICLS
610
EFHTQITRYV
Length:610
Mass (Da):68,312
Last modified:November 1, 1996 - v1
Checksum:i728A3F272DAED4BE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U36584 mRNA. Translation: AAA79949.1.
L47260 mRNA. Translation: AAA75347.1.
AE014134 Genomic DNA. Translation: AAF53776.1.
AY051852 mRNA. Translation: AAK93276.1.
AF147883 Genomic DNA. Translation: AAD41343.1.
PIRiS58885.
RefSeqiNP_477139.1. NM_057791.4.
UniGeneiDm.4108.

Genome annotation databases

EnsemblMetazoaiFBtr0081195; FBpp0080736; FBgn0015380.
FBtr0330209; FBpp0303242; FBgn0015380.
GeneIDi44355.
KEGGidme:Dmel_CG17348.
UCSCiCG17348-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U36584 mRNA. Translation: AAA79949.1.
L47260 mRNA. Translation: AAA75347.1.
AE014134 Genomic DNA. Translation: AAF53776.1.
AY051852 mRNA. Translation: AAK93276.1.
AF147883 Genomic DNA. Translation: AAD41343.1.
PIRiS58885.
RefSeqiNP_477139.1. NM_057791.4.
UniGeneiDm.4108.

3D structure databases

ProteinModelPortaliQ27324.
SMRiQ27324.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi69001. 10 interactors.
DIPiDIP-22284N.
IntActiQ27324. 1 interactor.
MINTiMINT-337834.
STRINGi7227.FBpp0303242.

Proteomic databases

PaxDbiQ27324.
PRIDEiQ27324.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0081195; FBpp0080736; FBgn0015380.
FBtr0330209; FBpp0303242; FBgn0015380.
GeneIDi44355.
KEGGidme:Dmel_CG17348.
UCSCiCG17348-RA. d. melanogaster.

Organism-specific databases

CTDi30167.
FlyBaseiFBgn0015380. drl.

Phylogenomic databases

eggNOGiKOG1024. Eukaryota.
ENOG410XSKI. LUCA.
GeneTreeiENSGT00810000125384.
InParanoidiQ27324.
KOiK05128.
OrthoDBiEOG091G0353.
PhylomeDBiQ27324.

Enzyme and pathway databases

BRENDAi2.7.10.1. 1994.
SignaLinkiQ27324.

Miscellaneous databases

GenomeRNAii44355.
PROiPR:Q27324.

Gene expression databases

BgeeiFBgn0015380.
ExpressionAtlasiQ27324. differential.
GenevisibleiQ27324. DM.

Family and domain databases

InterProiView protein in InterPro
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR003306. WIF.
PfamiView protein in Pfam
PF07714. Pkinase_Tyr. 1 hit.
PF02019. WIF. 1 hit.
PRINTSiPR00109. TYRKINASE.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD013948. WIF. 1 hit.
SMARTiView protein in SMART
SM00469. WIF. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50814. WIF. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRYK1_DROME
AccessioniPrimary (citable) accession number: Q27324
Secondary accession number(s): Q9U9Y3, Q9VIY6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 27, 2003
Last sequence update: November 1, 1996
Last modified: June 7, 2017
This is version 158 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.