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Protein

Metallothionein-B

Gene

MTB1

Organism
Strongylocentrotus purpuratus (Purple sea urchin)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Metallothioneins have a high content of cysteine residues that bind various heavy metals.

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Metal-thiolate cluster

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein-B
Short name:
MTB
Gene namesi
Name:MTB1
Synonyms:MTB
OrganismiStrongylocentrotus purpuratus (Purple sea urchin)
Taxonomic identifieri7668 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEchinodermataEleutherozoaEchinozoaEchinoideaEuechinoideaEchinaceaEchinoidaStrongylocentrotidaeStrongylocentrotus
Proteomesi
  • UP000007110 Componenti: Unassembled WGS sequence

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 6565Metallothionein-BPRO_0000197348Add
BLAST

Expressioni

Inductioni

By heavy metals.

Structurei

3D structure databases

ProteinModelPortaliQ27287.
SMRiQ27287. Positions 2-65.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiIPR017980. Metalthion_4_echinoid/annelid.
IPR001396. Metalthion_4_echinoidea.
IPR017854. Metalthion_dom.
[Graphical view]
PfamiPF05522. Metallothio_6. 1 hit.
[Graphical view]
PRINTSiPR00873. MTECHINOIDEA.
SUPFAMiSSF57868. SSF57868. 2 hits.

Sequencei

Sequence statusi: Complete.

Q27287-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPDVKCVCCK EGNECACTGQ DCCTIGKCCK DGTCCGKCSN AACKTCADGC
60
TCGSGCSCTE GNCPC
Length:65
Mass (Da):6,470
Last modified:November 1, 1996 - v1
Checksum:i12E1C8064D9121A5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15989 mRNA. Translation: AAA30063.1.
M59822 Genomic DNA. Translation: AAA30062.1.
PIRiA38739.
RefSeqiNP_999741.1. NM_214576.2.
UniGeneiSpu.20128.

Genome annotation databases

GeneIDi373378.
KEGGispu:373378.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15989 mRNA. Translation: AAA30063.1.
M59822 Genomic DNA. Translation: AAA30062.1.
PIRiA38739.
RefSeqiNP_999741.1. NM_214576.2.
UniGeneiSpu.20128.

3D structure databases

ProteinModelPortaliQ27287.
SMRiQ27287. Positions 2-65.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi373378.
KEGGispu:373378.

Organism-specific databases

CTDi373378.

Family and domain databases

InterProiIPR017980. Metalthion_4_echinoid/annelid.
IPR001396. Metalthion_4_echinoidea.
IPR017854. Metalthion_dom.
[Graphical view]
PfamiPF05522. Metallothio_6. 1 hit.
[Graphical view]
PRINTSiPR00873. MTECHINOIDEA.
SUPFAMiSSF57868. SSF57868. 2 hits.
ProtoNetiSearch...

Publicationsi

  1. "Metallothionein genes MTa and MTb expressed under distinct quantitative and tissue-specific regulation in sea urchin embryos."
    Wilkinson D.G., Nemer M.
    Mol. Cell. Biol. 7:48-58(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Structure, spatial, and temporal expression of two sea urchin metallothionein genes, SpMTB1 and SpMTA."
    Nemer M., Thornton R.D., Stuebing E.W., Harlow P.
    J. Biol. Chem. 266:6586-6593(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiMTB_STRPU
AccessioniPrimary (citable) accession number: Q27287
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: December 9, 2015
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Metallothioneins
    Classification of metallothioneins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.