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Protein

Metallothionein-B

Gene

MTB1

Organism
Strongylocentrotus purpuratus (Purple sea urchin)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Metallothioneins have a high content of cysteine residues that bind various heavy metals.

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Metal-thiolate cluster

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein-B
Short name:
MTB
Gene namesi
Name:MTB1
Synonyms:MTB
OrganismiStrongylocentrotus purpuratus (Purple sea urchin)
Taxonomic identifieri7668 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEchinodermataEleutherozoaEchinozoaEchinoideaEuechinoideaEchinaceaEchinoidaStrongylocentrotidaeStrongylocentrotus
ProteomesiUP000007110: Unplaced

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 6565Metallothionein-BPRO_0000197348Add
BLAST

Expressioni

Inductioni

By heavy metals.

Interactioni

Protein-protein interaction databases

STRINGi7668.Q27287.

Structurei

3D structure databases

ProteinModelPortaliQ27287.
SMRiQ27287. Positions 2-65.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiIPR017980. Metalthion_4_echinoid/annelid.
IPR001396. Metalthion_4_echinoidea.
IPR017854. Metalthion_dom.
[Graphical view]
PfamiPF05522. Metallothio_6. 1 hit.
[Graphical view]
PRINTSiPR00873. MTECHINOIDEA.
SUPFAMiSSF57868. SSF57868. 2 hits.

Sequencei

Sequence statusi: Complete.

Q27287-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPDVKCVCCK EGNECACTGQ DCCTIGKCCK DGTCCGKCSN AACKTCADGC
60
TCGSGCSCTE GNCPC
Length:65
Mass (Da):6,470
Last modified:November 1, 1996 - v1
Checksum:i12E1C8064D9121A5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15989 mRNA. Translation: AAA30063.1.
M59822 Genomic DNA. Translation: AAA30062.1.
PIRiA38739.
RefSeqiNP_999741.1. NM_214576.2.
UniGeneiSpu.20128.

Genome annotation databases

GeneIDi373378.
KEGGispu:373378.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15989 mRNA. Translation: AAA30063.1.
M59822 Genomic DNA. Translation: AAA30062.1.
PIRiA38739.
RefSeqiNP_999741.1. NM_214576.2.
UniGeneiSpu.20128.

3D structure databases

ProteinModelPortaliQ27287.
SMRiQ27287. Positions 2-65.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7668.Q27287.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi373378.
KEGGispu:373378.

Organism-specific databases

CTDi373378.

Family and domain databases

InterProiIPR017980. Metalthion_4_echinoid/annelid.
IPR001396. Metalthion_4_echinoidea.
IPR017854. Metalthion_dom.
[Graphical view]
PfamiPF05522. Metallothio_6. 1 hit.
[Graphical view]
PRINTSiPR00873. MTECHINOIDEA.
SUPFAMiSSF57868. SSF57868. 2 hits.
ProtoNetiSearch...

Publicationsi

  1. "Metallothionein genes MTa and MTb expressed under distinct quantitative and tissue-specific regulation in sea urchin embryos."
    Wilkinson D.G., Nemer M.
    Mol. Cell. Biol. 7:48-58(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Structure, spatial, and temporal expression of two sea urchin metallothionein genes, SpMTB1 and SpMTA."
    Nemer M., Thornton R.D., Stuebing E.W., Harlow P.
    J. Biol. Chem. 266:6586-6593(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiMTB_STRPU
AccessioniPrimary (citable) accession number: Q27287
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: January 7, 2015
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Metallothioneins
    Classification of metallothioneins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.