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Protein

Protein dif-1

Gene

dif-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Seems to play a role in the maintenance of tissue differentiation in the developing embryo, but not for its initiation.

GO - Molecular functioni

  • structural constituent of ribosome Source: GO_Central
  • transporter activity Source: UniProtKB

GO - Biological processi

  • mitochondrial transport Source: UniProtKB
  • multicellular organism development Source: UniProtKB-KW
  • translation Source: GO_Central
  • transmembrane transport Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiR-CEL-200425. Import of palmitoyl-CoA into the mitochondrial matrix.

Protein family/group databases

TCDBi2.A.29.8.2. the mitochondrial carrier (mc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein dif-1
Gene namesi
Name:dif-1
ORF Names:F49E8.5
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiF49E8.5; CE28408; WBGene00000996; dif-1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei5 – 2521Helical; Name=1Sequence analysisAdd
BLAST
Transmembranei69 – 8921Helical; Name=2Sequence analysisAdd
BLAST
Transmembranei104 – 12421Helical; Name=3Sequence analysisAdd
BLAST
Transmembranei172 – 19221Helical; Name=4Sequence analysisAdd
BLAST
Transmembranei209 – 22921Helical; Name=5Sequence analysisAdd
BLAST
Transmembranei261 – 28222Helical; Name=6Sequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial envelope Source: UniProtKB
  • mitochondrial inner membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 312312Protein dif-1PRO_0000090693Add
BLAST

Proteomic databases

EPDiQ27257.
PaxDbiQ27257.

Expressioni

Developmental stagei

Although dif-1 activity is required only during embryogenesis, it is expressed at all stages of development.

Interactioni

Protein-protein interaction databases

IntActiQ27257. 1 interaction.
STRINGi6239.F49E8.5.1.

Structurei

3D structure databases

ProteinModelPortaliQ27257.
SMRiQ27257. Positions 6-284.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati2 – 9392Solcar 1Add
BLAST
Repeati102 – 19392Solcar 2Add
BLAST
Repeati203 – 28987Solcar 3Add
BLAST

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0758. Eukaryota.
ENOG410XS86. LUCA.
GeneTreeiENSGT00700000104295.
HOGENOMiHOG000168307.
InParanoidiQ27257.
KOiK15109.
OMAiIANWGVC.
OrthoDBiEOG7TTQ8C.
PhylomeDBiQ27257.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002113. Aden_trnslctor.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00927. ADPTRNSLCASE.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q27257-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDVLLNFIA GGVGGSCTVI VGHPFDTVKV RIQTMPMPKP GEKPQFTGAL
60 70 80 90 100
DCVKRTVSKE GFFALYKGMA APLVGVSPLF AVFFGGCAVG KWLQQTDPSQ
110 120 130 140 150
EMTFIQNANA GALAGVFTTI VMVPGERIKC LLQVQQAGSA GSGVHYDGPL
160 170 180 190 200
DVVKKLYKQG GISSIYRGTG ATLLRDIPAS AAYLSVYEYL KKKFSGEGAQ
210 220 230 240 250
RTLSPGATLM AGGLAGIANW GVCIPADVLK SRLQTAPEGK YPDGIRGVLR
260 270 280 290 300
EVLREEGPRA LFKGFWPVML RAFPANAACF FGLELTLAAF RYFGIGGHPT
310
PSTEVVPLPH DE
Length:312
Mass (Da):33,135
Last modified:November 1, 1996 - v1
Checksum:iCCF1300CAE4DF64F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X76115 mRNA. Translation: CAA53721.1.
Z48240 Genomic DNA. Translation: CAA88283.1.
FO081280 Genomic DNA. Translation: CCD70447.1.
PIRiT29640.
RefSeqiNP_501223.1. NM_068822.5.
UniGeneiCel.8694.

Genome annotation databases

EnsemblMetazoaiF49E8.5.1; F49E8.5.1; WBGene00000996.
F49E8.5.2; F49E8.5.2; WBGene00000996.
GeneIDi177530.
KEGGicel:CELE_F49E8.5.
UCSCiF49E8.5.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X76115 mRNA. Translation: CAA53721.1.
Z48240 Genomic DNA. Translation: CAA88283.1.
FO081280 Genomic DNA. Translation: CCD70447.1.
PIRiT29640.
RefSeqiNP_501223.1. NM_068822.5.
UniGeneiCel.8694.

3D structure databases

ProteinModelPortaliQ27257.
SMRiQ27257. Positions 6-284.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ27257. 1 interaction.
STRINGi6239.F49E8.5.1.

Protein family/group databases

TCDBi2.A.29.8.2. the mitochondrial carrier (mc) family.

Proteomic databases

EPDiQ27257.
PaxDbiQ27257.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF49E8.5.1; F49E8.5.1; WBGene00000996.
F49E8.5.2; F49E8.5.2; WBGene00000996.
GeneIDi177530.
KEGGicel:CELE_F49E8.5.
UCSCiF49E8.5.1. c. elegans.

Organism-specific databases

CTDi177530.
WormBaseiF49E8.5; CE28408; WBGene00000996; dif-1.

Phylogenomic databases

eggNOGiKOG0758. Eukaryota.
ENOG410XS86. LUCA.
GeneTreeiENSGT00700000104295.
HOGENOMiHOG000168307.
InParanoidiQ27257.
KOiK15109.
OMAiIANWGVC.
OrthoDBiEOG7TTQ8C.
PhylomeDBiQ27257.

Enzyme and pathway databases

ReactomeiR-CEL-200425. Import of palmitoyl-CoA into the mitochondrial matrix.

Miscellaneous databases

PROiQ27257.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002113. Aden_trnslctor.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00927. ADPTRNSLCASE.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Extension of the mitochondrial transporter super-family: sequences of five members from the nematode worm, Caenorhabditis elegans."
    Runswick M.J., Philippides A., Lauria G., Walker J.E.
    DNA Seq. 4:281-291(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Embryonic tissue differentiation in Caenorhabditis elegans requires dif-1, a gene homologous to mitochondrial solute carriers."
    Ahringer J.
    EMBO J. 14:2307-2316(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Bristol N2.
  3. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiDIF1_CAEEL
AccessioniPrimary (citable) accession number: Q27257
Secondary accession number(s): Q20630
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: November 1, 1996
Last modified: July 6, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.