Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein dif-1

Gene

dif-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Seems to play a role in the maintenance of tissue differentiation in the developing embryo, but not for its initiation.

GO - Molecular functioni

  • carnitine:acyl carnitine antiporter activity Source: GO_Central
  • carnitine transmembrane transporter activity Source: GO_Central
  • transporter activity Source: UniProtKB

GO - Biological processi

  • carnitine transport Source: GO_Central
  • mitochondrial transport Source: UniProtKB
  • multicellular organism development Source: UniProtKB-KW

Keywordsi

Molecular functionDevelopmental protein
Biological processTransport

Enzyme and pathway databases

ReactomeiR-CEL-200425. Import of palmitoyl-CoA into the mitochondrial matrix.

Protein family/group databases

TCDBi2.A.29.8.2. the mitochondrial carrier (mc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein dif-1
Gene namesi
Name:dif-1
ORF Names:F49E8.5
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiF49E8.5; CE28408; WBGene00000996; dif-1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei5 – 25Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei69 – 89Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei104 – 124Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei172 – 192Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei209 – 229Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei261 – 282Helical; Name=6Sequence analysisAdd BLAST22

GO - Cellular componenti

  • integral component of membrane Source: GO_Central
  • mitochondrial envelope Source: UniProtKB
  • mitochondrial inner membrane Source: GO_Central

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000906931 – 312Protein dif-1Add BLAST312

Proteomic databases

EPDiQ27257.
PaxDbiQ27257.
PeptideAtlasiQ27257.
PRIDEiQ27257.

Expressioni

Developmental stagei

Although dif-1 activity is required only during embryogenesis, it is expressed at all stages of development.

Gene expression databases

BgeeiWBGene00000996.

Interactioni

Protein-protein interaction databases

IntActiQ27257. 1 interactor.
STRINGi6239.F49E8.5.1.

Structurei

3D structure databases

ProteinModelPortaliQ27257.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati2 – 93Solcar 1Add BLAST92
Repeati102 – 193Solcar 2Add BLAST92
Repeati203 – 289Solcar 3Add BLAST87

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0758. Eukaryota.
ENOG410XS86. LUCA.
GeneTreeiENSGT00700000104295.
HOGENOMiHOG000168307.
InParanoidiQ27257.
KOiK15109.
OMAiNIVAPNF.
OrthoDBiEOG091G0HVE.
PhylomeDBiQ27257.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiView protein in InterPro
IPR002113. Aden_trnslctor.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
PfamiView protein in Pfam
PF00153. Mito_carr. 3 hits.
PRINTSiPR00927. ADPTRNSLCASE.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiView protein in PROSITE
PS50920. SOLCAR. 3 hits.

Sequencei

Sequence statusi: Complete.

Q27257-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDVLLNFIA GGVGGSCTVI VGHPFDTVKV RIQTMPMPKP GEKPQFTGAL
60 70 80 90 100
DCVKRTVSKE GFFALYKGMA APLVGVSPLF AVFFGGCAVG KWLQQTDPSQ
110 120 130 140 150
EMTFIQNANA GALAGVFTTI VMVPGERIKC LLQVQQAGSA GSGVHYDGPL
160 170 180 190 200
DVVKKLYKQG GISSIYRGTG ATLLRDIPAS AAYLSVYEYL KKKFSGEGAQ
210 220 230 240 250
RTLSPGATLM AGGLAGIANW GVCIPADVLK SRLQTAPEGK YPDGIRGVLR
260 270 280 290 300
EVLREEGPRA LFKGFWPVML RAFPANAACF FGLELTLAAF RYFGIGGHPT
310
PSTEVVPLPH DE
Length:312
Mass (Da):33,135
Last modified:November 1, 1996 - v1
Checksum:iCCF1300CAE4DF64F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X76115 mRNA. Translation: CAA53721.1.
Z48240 Genomic DNA. Translation: CAA88283.1.
FO081280 Genomic DNA. Translation: CCD70447.1.
PIRiT29640.
RefSeqiNP_501223.1. NM_068822.5.
UniGeneiCel.8694.

Genome annotation databases

EnsemblMetazoaiF49E8.5.1; F49E8.5.1; WBGene00000996.
F49E8.5.2; F49E8.5.2; WBGene00000996.
GeneIDi177530.
KEGGicel:CELE_F49E8.5.
UCSCiF49E8.5.1. c. elegans.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiDIF1_CAEEL
AccessioniPrimary (citable) accession number: Q27257
Secondary accession number(s): Q20630
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: November 1, 1996
Last modified: June 7, 2017
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families