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Protein

ADP,ATP carrier protein 1

Gene

AGAP006782

Organism
Anopheles gambiae (African malaria mosquito)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the exchange of ADP and ATP across the mitochondrial inner membrane.

Miscellaneous

The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. Odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei82NucleotideBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
ADP,ATP carrier protein 1
Alternative name(s):
ADP/ATP translocase 1
Adenine nucleotide translocator 1
Short name:
ANT 1
Gene namesi
ORF Names:AGAP006782
OrganismiAnopheles gambiae (African malaria mosquito)
Taxonomic identifieri7165 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraNematoceraCulicoideaCulicidaeAnophelinaeAnopheles
Proteomesi
  • UP000007062 Componentsi: Chromosome 2L, Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei7 – 41Helical; Name=1By similarityAdd BLAST35
Transmembranei77 – 102Helical; Name=2By similarityAdd BLAST26
Transmembranei111 – 145Helical; Name=3By similarityAdd BLAST35
Transmembranei178 – 204Helical; Name=4By similarityAdd BLAST27
Transmembranei209 – 243Helical; Name=5By similarityAdd BLAST35
Transmembranei275 – 300Helical; Name=6By similarityAdd BLAST26

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000905861 – 301ADP,ATP carrier protein 1Add BLAST301

Proteomic databases

PaxDbiQ27238.
PRIDEiQ27238.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi7165.AGAP006782-PA.

Structurei

3D structure databases

ProteinModelPortaliQ27238.
SMRiQ27238.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati8 – 100Solcar 1Add BLAST93
Repeati113 – 203Solcar 2Add BLAST91
Repeati210 – 299Solcar 3Add BLAST90

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi237 – 242Substrate recognitionBy similarity6

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0749. Eukaryota.
ENOG410XNW0. LUCA.
HOGENOMiHOG000165727.
InParanoidiQ27238.
KOiK05863.
OrthoDBiEOG091G0ULB.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiView protein in InterPro
IPR002113. Aden_trnslctor.
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
PfamiView protein in Pfam
PF00153. Mito_carr. 3 hits.
PRINTSiPR00927. ADPTRNSLCASE.
PR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiView protein in PROSITE
PS50920. SOLCAR. 3 hits.

Sequencei

Sequence statusi: Complete.

Q27238-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKKADPYGF AKDFLAGGIS AAVSKTAVAP IERVKLLLQV QAASKQIAVD
60 70 80 90 100
KQYKGIVDCF VRIPKEQGIG AFWRGNLANV IRYFPTQALN FAFKDVYKQV
110 120 130 140 150
FLGGVDKNTQ FWRYFLGNLG SGGAAGATSL CFVYPLDFAR TRLGADVGRG
160 170 180 190 200
AGEREFNGLL DCLKKTVKSD GIIGLYRGFN VSVQGIIIYR AAYFGCFDTA
210 220 230 240 250
KGMLPDPKNT SIFVSWAIAQ VVTTASGIIS YPFDTVRRRM MMQSGRAKSE
260 270 280 290 300
VMYKNTLDCW VKIGKQEGSG AFFKGAFSNV LRGTGGALVL VFYDEVKALL

G
Length:301
Mass (Da):32,820
Last modified:April 4, 2006 - v2
Checksum:i4ACDF42EAD8DA125
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti51K → Q in EAA04717 (PubMed:12364791).Curated1
Sequence conflicti149R → P in AAB04104 (PubMed:8069414).Curated1
Sequence conflicti149R → P in AAB04105 (PubMed:8069414).Curated1
Sequence conflicti245 – 247GRA → WPC in AAB04104 (PubMed:8069414).Curated3
Sequence conflicti245 – 247GRA → WPC in AAB04105 (PubMed:8069414).Curated3
Sequence conflicti264G → A in EAA04717 (PubMed:12364791).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L11617 mRNA. Translation: AAB04105.1.
L11618 mRNA. Translation: AAB04104.1.
AY227001 mRNA. Translation: AAO32818.2.
AAAB01008807 Genomic DNA. Translation: EAA04717.2.
PIRiS31935.
RefSeqiXP_308964.2. XM_308964.4.

Genome annotation databases

GeneIDi1270282.
KEGGiaga:AgaP_AGAP006782.

Similar proteinsi

Entry informationi

Entry nameiADT1_ANOGA
AccessioniPrimary (citable) accession number: Q27238
Secondary accession number(s): Q7QIC6, Q86PG1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: April 4, 2006
Last modified: April 12, 2017
This is version 102 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families