Reviewed, UniProtKB/Swiss-Prot Q27203 (HPPD_TETTH)

Names and origin

Protein names

Recommended name:
    4-hydroxyphenylpyruvate dioxygenase
    EC=1.13.11.27
Alternative name(s):
    4-hydroxyphenylpyruvic acid oxidase
      Short name=HPPDase
      Short name=4HPPD
      Short name=HPD
    F-antigen homolog
    TF-AG

Gene names

Name:

TFA

Organism

Tetrahymena thermophila

Taxonomic identifier

5911 [NCBI]

Taxonomic lineage

Eukaryota › Alveolata › Ciliophora › Intramacronucleata › Oligohymenophorea › Hymenostomatida › Tetrahymenina › Tetrahymenidae › Tetrahymena

Protein attributes

Sequence length	404 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	4-hydroxyphenylpyruvate + O(2) = homogentisate + CO(2).
Cofactor	Binds 1 iron ion per subunit By similarity.
Pathway	Amino-acid degradation; L-phenylalanine degradation; acetoacetic acid and fumarate from L-phenylalanine: step 3/6.
Sequence similarities	Belongs to the 4HPPD family.

Ontologies

Keywords
Biological process	Phenylalanine catabolism Tyrosine catabolism
Ligand	Iron Metal-binding
Molecular function	Dioxygenase Oxidoreductase
Gene Ontology (GO)
Biological process	L-phenylalanine catabolic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW tyrosine catabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	4-hydroxyphenylpyruvate dioxygenase activity Inferred from electronic annotation. Source: InterPro iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 404	404	4-hydroxyphenylpyruvate dioxygenase		PRO_0000088396
Sites
	Metal binding	197	1	Iron By similarity
	Metal binding	280	1	Iron By similarity
	Metal binding	364	1	Iron By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q27203-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 48DADC8AEE5D1837	FASTA	404	46,046
	10 20 30 40 50 60 MSENKDHVVV GYTEKPVGER PTGGKFLGYD HLHFWVGNAK QAAGWYTSRF GFEYYAYKGL 70 80 90 100 110 120 ETGSREVATH VVRNKQGVTL AFSTPYGNDK DNQREMNQHQ SLHGDGVKDV AFAVEDCHSI 130 140 150 160 170 180 YNKAIQRGAK CAYPPQDLKD EHGSVTIAAV HTYGEVIHTF IQRNDYKGFF MPGFVAHPLK 190 200 210 220 230 240 DPLNNVLPDI SYNYVDHIVG NQPDNMMTSA ADWYEKTLDF HRFWSVDDSM IHTEFSSLRS 250 260 270 280 290 300 IVMTDYDQKI KMPINEPADG KRKSQIQEYI DFYAGPGVQH IALNTSDVIN TVEGLRARGV 310 320 330 340 350 360 EFLSIPTSYY DNLRKALTAQ TSITVKEDLD VLQKNHILVD YDEKGYLLQI FTKPVEDRPT 370 380 390 400 LFYEIIQRNN HQGFGAGNFK SLFVSLELEQ EKRGNLTEIV KNIY

References

[1]

"Tetrahymena gene encodes a protein that is homologous with the liver-specific F-antigen and associated with membranes of the Golgi apparatus and transport vesicles." Hummel R., Noergaard P., Andreasen P.H., Neve S., Skjoedt K., Tornehave D., Kristiansen K. J. Mol. Biol. 228:850-861(1992) [PubMed: 1469718] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: B1868.

Cross-references

Sequence databases
EMBLGenBankDDBJ	M59429 Genomic DNA. Translation: AAA96492.1.
PIR	S27339.
3D structure databases
HSSP	HSSP built from PDB template 1CJX based on UniProtKB P80064.
ModBase	Search...
Family and domain databases
InterPro	IPR005956. 4OHPhenylPyrv_dOase. IPR004360. Glyas_bleo-R_dOase. [Graphical view]
PANTHER	PTHR11959. HPP_dOase. 1 hit.
Pfam	PF00903. Glyoxalase. 1 hit. [Graphical view]
PIRSF	PIRSF009283. HPP_dOase. 1 hit.
TIGRFAMs	TIGR01263. 4HPPD. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HPPD_TETTH

Accession

Primary (citable) accession number: Q27203

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	November 1, 1996
Last modified:	November 25, 2008
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)