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Q27181

- T2C_PARTE

UniProt

Q27181 - T2C_PARTE

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Protein

Trichocyst matrix protein T2-C

Gene

T2C

Organism
Paramecium tetraurelia
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Structural protein that crystallize inside the trichocyst matrix.

Names & Taxonomyi

Protein namesi
Recommended name:
Trichocyst matrix protein T2-C
Alternative name(s):
Secretory granule protein T2-C
TMP 2-C
Cleaved into the following 2 chains:
Gene namesi
Name:T2C
ORF Names:GSPATT00003811001
OrganismiParamecium tetraurelia
Taxonomic identifieri5888 [NCBI]
Taxonomic lineageiEukaryotaAlveolataCiliophoraIntramacronucleataOligohymenophoreaPeniculidaParameciidaeParamecium
ProteomesiUP000000600: Partially assembled WGS sequence

Subcellular locationi

Trichocyst
Note: These are architecturally complex secretory storage granules-docked at the plasma membrane, ready to rapidly respond to an exocytotic stimulus.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Propeptidei20 – 4829PRO_0000034381Add
BLAST
Chaini49 – 183135Trichocyst matrix protein T2-C 1PRO_0000034382Add
BLAST
Propeptidei184 – 23956PRO_0000034383Add
BLAST
Chaini240 – 387148Trichocyst matrix protein T2-C 2PRO_0000034384Add
BLAST

Post-translational modificationi

Two components are produced by post-translational processing from the precursor peptide.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili51 – 163113Sequence AnalysisAdd
BLAST
Coiled coili294 – 33340Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the TMP family.Curated

Keywords - Domaini

Coiled coil, Signal

Phylogenomic databases

InParanoidiQ27181.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q27181-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MKTIILALAL IVLASSTQAD VIATIKKIDQ SPFGRTLFDT IWLELQTGDP
60 70 80 90 100
LDRLLQTLTD LEDRYVAEQK EDDARNHEYQ DACTVDIKAF DKDLAESNRK
110 120 130 140 150
KIELEARLEG QLYPQRGILQ GLVAQKQAEV KGYQKDLDEL DAQRAEEKAD
160 170 180 190 200
FEEKVLEHQE ATAIIAEARR LFADNIEHES FIQKGKATKQ PAHKFTKEVA
210 220 230 240 250
SMIQKHFTTS AKKAAKFQHR KGYSKLFKAF ATIASKVEQL ADAGAVSKII
260 270 280 290 300
DLADELLAKI ADSLSLLRFA EDKRVEAYKK SRNFIVISLT VAGTALANAQ
310 320 330 340 350
SDLAALNDVI AQVEASLDTT NQRIENVSAD RNDRFTQCEE AVQDYQDARS
360 370 380
ARSSDRDVVS QTIGLVNKEL RTLREQLALR QSAGEEI
Length:387
Mass (Da):43,312
Last modified:November 1, 1996 - v1
Checksum:iD6885D7E22EED1D8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U47116 Genomic DNA. Translation: AAC47028.1.
CT868660 Genomic DNA. Translation: CAK90946.1.
U27511 Genomic DNA. Translation: AAA92611.1.
RefSeqiXP_001458343.1. XM_001458306.1.
UniGeneiPte.18177.

Genome annotation databases

EnsemblProtistsiCAK90946; CAK90946; GSPATT00003811001.
GeneIDi5044128.
KEGGiptm:GSPATT00003811001.

Cross-referencesi

Web resourcesi

Protein Spotlight

The arsenal of Paramecium - Issue 3 of October 2000

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U47116 Genomic DNA. Translation: AAC47028.1 .
CT868660 Genomic DNA. Translation: CAK90946.1 .
U27511 Genomic DNA. Translation: AAA92611.1 .
RefSeqi XP_001458343.1. XM_001458306.1.
UniGenei Pte.18177.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi CAK90946 ; CAK90946 ; GSPATT00003811001 .
GeneIDi 5044128.
KEGGi ptm:GSPATT00003811001.

Phylogenomic databases

InParanoidi Q27181.

Family and domain databases

ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and sequence analysis of genes coding for paramecium secretory granule (trichocyst) proteins. A unique protein fold for a family of polypeptides with different primary structures."
    Gautier M.-C., Sperling L., Madeddu L.
    J. Biol. Chem. 271:10247-10255(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Stock d4-2.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Stock d4-2.
  3. "A large multigene family codes for the polypeptides of the crystalline trichocyst matrix in Paramecium."
    Madeddu L., Gautier M.-C., Vayssie L., Houari A., Sperling L.
    Mol. Biol. Cell 6:649-659(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 49-72.
    Strain: Stock d4-2.
  4. "Protein processing and morphogenesis of secretory granules in Paramecium."
    Madeddu L., Gautier M.-C., le Caer J.-P., de Loubresse N., Sperling L.
    Biochimie 76:329-335(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL PROTEIN SEQUENCE.
    Strain: Stock d4-2.

Entry informationi

Entry nameiT2C_PARTE
AccessioniPrimary (citable) accession number: Q27181
Secondary accession number(s): A0E6M9, Q27175
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3