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Q27173 (T2A_PARTE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Trichocyst matrix protein T2-A
Alternative name(s):
Secretory granule protein T2-A
TMP 2-A
Gene names
Name:T2A
ORF Names:GSPATT00008245001
OrganismParamecium tetraurelia [Reference proteome]
Taxonomic identifier5888 [NCBI]
Taxonomic lineageEukaryotaAlveolataCiliophoraIntramacronucleataOligohymenophoreaPeniculidaParameciidaeParamecium

Protein attributes

Sequence length386 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Structural protein that crystallize inside the trichocyst matrix.

Subcellular location

Trichocyst. Note: These are architecturally complex secretory storage granules-docked at the plasma membrane, ready to rapidly respond to an exocytotic stimulus.

Sequence similarities

Belongs to the TMP family.

Ontologies

Keywords
   DomainCoiled coil
Signal
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Cellular_componenttrichocyst

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Propeptide20 – 4829 By similarity
PRO_0000307846
Chain49 – 183135Trichocyst matrix protein T2-A 1
PRO_0000221508
Propeptide184 – 23855 By similarity
PRO_0000307847
Chain239 – 386148Trichocyst matrix protein T2-A 2
PRO_0000307848

Regions

Coiled coil51 – 154104 Potential
Coiled coil293 – 33240 Potential

Sequences

Sequence LengthMass (Da)Tools
Q27173 [UniParc].

Last modified October 23, 2007. Version 2.
Checksum: 82B6BC32D32A574B

FASTA38643,207
        10         20         30         40         50         60 
MKTVILALAL IVLASSTQAD VIATIKKIDQ SPFGRTLFDT IYLELQTGDP LDRLLSTLTD 

        70         80         90        100        110        120 
LEDRYVAEQK EDDAKNQEYQ GACTVDISAF DKDLAESNRK KIELEARLEG QLYPQRSILE 

       130        140        150        160        170        180 
GLVAQKKAEV KGYQKDLDEL DAQRAEEHED FEEKVLEHQE ATAIIAEARR LFADNIEHGS 

       190        200        210        220        230        240 
FIQKGKATKQ THKFTKEVAS MIQKHFTTSA KKTAKFQHRK GYSKLFKAFA TIASKVEQLA 

       250        260        270        280        290        300 
DAGAVQKIID LADELLAKIA DSLSLLRFAE DKRVEAYKKS RNFIVISLNV AGSALANATS 

       310        320        330        340        350        360 
DLASLNDIIA QVEASLDTTE QRIENVSADR HDRFTQCEEA VQDYQDARAA RTSDRDVVSQ 

       370        380 
TIGLVNKELR TLREQLALRQ QAGEEI 

« Hide

References

« Hide 'large scale' references
[1]"Global trends of whole-genome duplications revealed by the ciliate Paramecium tetraurelia."
Aury J.-M., Jaillon O., Duret L., Noel B., Jubin C., Porcel B.M., Segurens B., Daubin V., Anthouard V., Aiach N., Arnaiz O., Billaut A., Beisson J., Blanc I., Bouhouche K., Camara F., Duharcourt S., Guigo R. expand/collapse author list , Gogendeau D., Katinka M., Keller A.-M., Kissmehl R., Klotz C., Koll F., Le Mouel A., Lepere G., Malinsky S., Nowacki M., Nowak J.K., Plattner H., Poulain J., Ruiz F., Serrano V., Zagulski M., Dessen P., Betermier M., Weissenbach J., Scarpelli C., Schaechter V., Sperling L., Meyer E., Cohen J., Wincker P.
Nature 444:171-178(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Stock d4-2.
[2]"A large multigene family codes for the polypeptides of the crystalline trichocyst matrix in Paramecium."
Madeddu L., Gautier M.-C., Vayssie L., Houari A., Sperling L.
Mol. Biol. Cell 6:649-659(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 49-71.
Strain: Stock d4-2.
[3]"Protein processing and morphogenesis of secretory granules in Paramecium."
Madeddu L., Gautier M.-C., le Caer J.-P., de Loubresse N., Sperling L.
Biochimie 76:329-335(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: PARTIAL PROTEIN SEQUENCE.
Strain: Stock d4-2.

Web resources

Protein Spotlight

The arsenal of Paramecium - Issue 3 of October 2000

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CT868097 Genomic DNA. Translation: CAK71696.1.
U27509 Genomic DNA. Translation: AAA92609.1.
RefSeqXP_001439093.1. XM_001439056.1.
UniGenePte.896.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsCAK71696; CAK71696; GSPATT00008245001.
GeneID5024878.
KEGGptm:GSPATT00008245001.

Family and domain databases

ProtoNetSearch...

Entry information

Entry nameT2A_PARTE
AccessionPrimary (citable) accession number: Q27173
Secondary accession number(s): A0CLM9
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: October 23, 2007
Last modified: May 14, 2014
This is version 54 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Protein Spotlight

Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries