ID   CDC2H_THEPA             Reviewed;         298 AA.
AC   Q27032;
DT   18-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   16-JUN-2009, entry version 65.
DE   RecName: Full=Cell division control protein 2 homolog;
DE            EC=2.7.11.22;
DE            EC=2.7.11.23;
GN   Name=CRK2; OrderedLocusNames=TP01_0728;
OS   Theileria parva.
OC   Eukaryota; Alveolata; Apicomplexa; Aconoidasida; Piroplasmida;
OC   Theileriidae; Theileria.
OX   NCBI_TaxID=5875;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Muguga;
RX   MEDLINE=97084571; PubMed=8930914;
RX   DOI=10.1046/j.1365-2958.1996.00124.x;
RA   Kinnaird J.H., Logan M., Kirvar E., Tait A., Carrington M.;
RT   "The isolation and characterisation of genomic and cDNA clones coding
RT   for a cdc2-related kinase (ThCRK2) from the bovine protozoan parasite
RT   Theileria.";
RL   Mol. Microbiol. 22:293-302(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Muguga;
RX   PubMed=15994558; DOI=10.1126/science.1110439;
RA   Gardner M.J., Bishop R., Shah T., de Villiers E.P., Carlton J.M.,
RA   Hall N., Ren Q., Paulsen I.T., Pain A., Berriman M., Wilson R.J.M.,
RA   Sato S., Ralph S.A., Mann D.J., Xiong Z., Shallom S.J., Weidman J.,
RA   Jiang L., Lynn J., Weaver B., Shoaibi A., Domingo A.R., Wasawo D.,
RA   Crabtree J., Wortman J.R., Haas B., Angiuoli S.V., Creasy T.H., Lu C.,
RA   Suh B., Silva J.C., Utterback T.R., Feldblyum T.V., Pertea M.,
RA   Allen J., Nierman W.C., Taracha E.L.N., Salzberg S.L., White O.R.,
RA   Fitzhugh H.A., Morzaria S., Venter J.C., Fraser C.M., Nene V.;
RT   "Genome sequence of Theileria parva, a bovine pathogen that transforms
RT   lymphocytes.";
RL   Science 309:134-137(2005).
CC   -!- FUNCTION: Plays a key role in the control of the eukaryotic cell
CC       cycle. It is required in higher cells for entry into S-phase and
CC       mitosis. Component of the kinase complex that phosphorylates the
CC       repetitive C-terminus of RNA polymerase II (By similarity).
CC   -!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
CC   -!- CATALYTIC ACTIVITY: ATP + [DNA-directed RNA polymerase] = ADP +
CC       [DNA-directed RNA polymerase] phosphate.
CC   -!- ENZYME REGULATION: Phosphorylation at Thr-14 or Tyr-15 inactivates
CC       the enzyme, while phosphorylation at Thr-158 activates it (By
CC       similarity).
CC   -!- SUBUNIT: Forms a stable but non-covalent complex with a regulatory
CC       subunit and with a cyclin (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. CMGC
CC       Ser/Thr protein kinase family. CDC2/CDKX subfamily.
CC   -!- SIMILARITY: Contains 1 protein kinase domain.
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DR   EMBL; X98824; CAA67342.1; -; Genomic_DNA.
DR   EMBL; AAGK01000001; EAN33966.1; -; Genomic_DNA.
DR   RefSeq; XP_766249.1; -.
DR   HSSP; P24941; 1OIQ.
DR   SMR; Q27032; 1-286.
DR   GeneID; 3503486; -.
DR   KEGG; tpv:TP01_0728; -.
DR   BRENDA; 2.7.11.22; 288010.
DR   BRENDA; 2.7.11.23; 288010.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004693; F:cyclin-dependent protein kinase activity; IEA:EC.
DR   GO; GO:0008353; F:RNA polymerase subunit kinase activity; IEA:EC.
DR   GO; GO:0006468; P:protein amino acid phosphorylation; IEA:InterPro.
DR   InterPro; IPR000719; Prot_kinase_core.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR017442; Se/Thr_pkinase-rel.
DR   InterPro; IPR008271; Ser_thr_pkin_AS.
DR   InterPro; IPR002290; Ser_thr_pkinase.
DR   Pfam; PF00069; Pkinase; 1.
DR   ProDom; PD000001; Prot_kinase; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding;
KW   Phosphoprotein; Serine/threonine-protein kinase; Transferase.
FT   CHAIN         1    298       Cell division control protein 2 homolog.
FT                                /FTId=PRO_0000232674.
FT   DOMAIN        4    284       Protein kinase.
FT   NP_BIND      10     18       ATP (By similarity).
FT   ACT_SITE    125    125       Proton acceptor (By similarity).
FT   BINDING      32     32       ATP (By similarity).
FT   MOD_RES      14     14       Phosphothreonine (By similarity).
FT   MOD_RES      15     15       Phosphotyrosine (By similarity).
FT   MOD_RES     158    158       Phosphothreonine; by CAK (By similarity).
SQ   SEQUENCE   298 AA;  34213 MW;  0C25B84458B1341C CRC64;
     MRRYHKMEKI GEGTYGVVYK AQNNHGEICA LKKIRVEEED EGIPSTAIRE ISLLKELHHP
     NIVWLRDVIH SEKCLTLVFE YLDQDLKKLL DACDGGLEPT TAKSFLYQIL RGISYCHDHR
     ILHRDLKPQN LLINREGVLK LADFGLARAF AIPVRSYTHE VVTLWYRAPD VLMGSKKYST
     AVDIWSVGCI FAEMINGVPL FPGISEQDQL KRIFKILGTP SVDSWPQVVN LPAYNPDFSY
     YEKQSWSSIV PKLNESGIDL ISRMLQLDPV QRISAKEALK HDYFKDLHRP PEFLNGVH
//