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Q27032

- CDC2H_THEPA

UniProt

Q27032 - CDC2H_THEPA

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Protein
Cell division control protein 2 homolog
Gene
CRK2, TP01_0728
Organism
Theileria parva (East coast fever infection agent)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Plays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis. Component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II By similarity.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Enzyme regulationi

Phosphorylation at Thr-14 or Tyr-15 inactivates the enzyme, while phosphorylation at Thr-158 activates it By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei32 – 321ATP By similarity
Active sitei125 – 1251Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 189ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. RNA polymerase II carboxy-terminal domain kinase activity Source: UniProtKB-EC
  3. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division control protein 2 homolog (EC:2.7.11.22, EC:2.7.11.23)
Gene namesi
Name:CRK2
Ordered Locus Names:TP01_0728
OrganismiTheileria parva (East coast fever infection agent)
Taxonomic identifieri5875 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaPiroplasmidaTheileriidaeTheileria
ProteomesiUP000001949: Unassembled WGS sequence

Organism-specific databases

EuPathDBiPiroplasmaDB:TP01_0728.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 298298Cell division control protein 2 homolog
PRO_0000232674Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei14 – 141Phosphothreonine By similarity
Modified residuei15 – 151Phosphotyrosine By similarity
Modified residuei158 – 1581Phosphothreonine; by CAK By similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Forms a stable but non-covalent complex with a regulatory subunit and with a cyclin By similarity.

Protein-protein interaction databases

STRINGi5875.TP01_0728.

Structurei

3D structure databases

ProteinModelPortaliQ27032.
SMRiQ27032. Positions 1-286.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 284281Protein kinase
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000233024.
KOiK04563.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q27032-1 [UniParc]FASTAAdd to Basket

« Hide

MRRYHKMEKI GEGTYGVVYK AQNNHGEICA LKKIRVEEED EGIPSTAIRE    50
ISLLKELHHP NIVWLRDVIH SEKCLTLVFE YLDQDLKKLL DACDGGLEPT 100
TAKSFLYQIL RGISYCHDHR ILHRDLKPQN LLINREGVLK LADFGLARAF 150
AIPVRSYTHE VVTLWYRAPD VLMGSKKYST AVDIWSVGCI FAEMINGVPL 200
FPGISEQDQL KRIFKILGTP SVDSWPQVVN LPAYNPDFSY YEKQSWSSIV 250
PKLNESGIDL ISRMLQLDPV QRISAKEALK HDYFKDLHRP PEFLNGVH 298
Length:298
Mass (Da):34,213
Last modified:November 1, 1996 - v1
Checksum:i0C25B84458B1341C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X98824 Genomic DNA. Translation: CAA67342.1.
AAGK01000001 Genomic DNA. Translation: EAN33966.1.
RefSeqiXP_766249.1. XM_761156.1.

Genome annotation databases

GeneIDi3503486.
KEGGitpv:TP01_0728.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X98824 Genomic DNA. Translation: CAA67342.1 .
AAGK01000001 Genomic DNA. Translation: EAN33966.1 .
RefSeqi XP_766249.1. XM_761156.1.

3D structure databases

ProteinModelPortali Q27032.
SMRi Q27032. Positions 1-286.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5875.TP01_0728.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3503486.
KEGGi tpv:TP01_0728.

Organism-specific databases

EuPathDBi PiroplasmaDB:TP01_0728.

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000233024.
KOi K04563.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The isolation and characterisation of genomic and cDNA clones coding for a cdc2-related kinase (ThCRK2) from the bovine protozoan parasite Theileria."
    Kinnaird J.H., Logan M., Kirvar E., Tait A., Carrington M.
    Mol. Microbiol. 22:293-302(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Muguga.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Muguga.

Entry informationi

Entry nameiCDC2H_THEPA
AccessioniPrimary (citable) accession number: Q27032
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: November 1, 1996
Last modified: May 14, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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