Unreviewed, UniProtKB/TrEMBL Q26966 (Q26966_TRYCR)

Names and origin

Protein names	Submitted name:     Trans-sialidase EMBL AAA66352.1
Organism	Trypanosoma cruzi EMBL AAA66352.1
Taxonomic identifier	5693 [NCBI]
Taxonomic lineage	Eukaryota › Euglenozoa › Kinetoplastida › Trypanosomatidae › Trypanosoma › Schizotrypanum

Protein attributes

Sequence length	642 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

Ontologies

Gene Ontology (GO)
Biological process	pathogenesis Inferred from electronic annotation. Source: InterPro
Molecular function	exo-alpha-sialidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q26966-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 65BD95DD7ADBC222	FASTA	642	70,593
	10 20 30 40 50 60 MLAPGSSRVE LFKRQSSKVP FEKDGKVTER VVHSFRLPAL VNVDGVMVAI ADARYETSND 70 80 90 100 110 120 NSLIDTVAKY SVDDGETWET QIAIKNSRAS SVSRVVDPTV IVKGNKLYVL VGSYNSSRSY 130 140 150 160 170 180 WTSHGDARDW DILLAVGEVT KSTAGGKITA SIKWGSPVSL KEFFPAEMEG MHTNQFLGGA 190 200 210 220 230 240 GVAIVASNGN LVYPVQVTNK KKQVFSKIFY SEDEGKTWKF GKGRSAFGCS EPVALEWEGK 250 260 270 280 290 300 LIINTRVDYR RRLVYESSDM GNSWLEAVGT LSRVWGPSPK SNQPGSQSSF TAVTIEGMRV 310 320 330 340 350 360 MLFTHPLNFK GRWLRDRLNL WLTDNQRIYN VGQVSIGDEN SAYSSVLYKD DKLYCLHEIN 370 380 390 400 410 420 SNEVYSLVFA RLVGELRIIK SVLQSWKNWD SHLSSICTPA DPAASSSERG CGPAVTTVGL 430 440 450 460 470 480 VGFLSHSATK TEWEDAYRCV NASTANAERV PNGLKFAGVG GGALWPVSQQ GQNQRYRFAN 490 500 510 520 530 540 HAFTVVASVT IHEVPSVASP LLGASLDSSG GKKLLGLSYD ERHQWQPIYG STPVTPTGSW 550 560 570 580 590 600 EMGKRYHVVL TMANKIGSEY IDGEPLEGSG QTVVPDERTP DISHFYVGGY KRSDMPTISH 610 620 630 640 VTVNNVLLYN RQLNAEEIRT LFLSQDLIGT EAHMDSSSDT SA

References

[1]	"A recombinant Trypanosoma cruzi trans-sialidase lacking the amino acid repeats retains the enzymatic activity." Campetella O.E., Uttaro A.D., Parodi A.J., Frasch A.C. Mol. Biochem. Parasitol. 64:337-340(1994) [PubMed: 7935611] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[2]	"The crystal structure and mode of action of trans-sialidase, a key enzyme in Trypanosoma cruzi pathogenesis." Buschiazzo A., Amaya M.F., Cremona M.L., Frasch A.C., Alzari P.M. Mol. Cell 10:757-768(2002) [PubMed: 12419220] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.25 ANGSTROMS) OF 2-635.
[3]	"Structural insights into the catalytic mechanism of Trypanosoma cruzi trans-sialidase." Amaya M.F., Watts A.G., Damager I., Wehenkel A., Nguyen T., Buschiazzo A., Paris G., Frasch A.C., Withers S.G., Alzari P.M. Structure 12:775-784(2004) [PubMed: 15130470] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS) OF 2-635.

Cross-references

Sequence databases

EMBLGenBankDDBJ

L26499 Genomic DNA. Translation: AAA66352.1.

3D structure databases

PDBPDBe

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1MR5	X-ray	2.25	A	2-635	[»]
1MS0	X-ray	2.50	A/B	2-635	[»]
1MS1	X-ray	1.80	A/B	2-635	[»]
1MS3	X-ray	1.65	A/B	2-635	[»]
1MS4	X-ray	2.21	A/B	2-635	[»]
1MS5	X-ray	2.00	A/B	2-635	[»]
1MS8	X-ray	2.00	A/B	2-635	[»]
1MS9	X-ray	1.58	A/B	2-635	[»]
1S0I	X-ray	1.60	A	2-635	[»]
1S0J	X-ray	1.65	A	2-635	[»]
2AH2	X-ray	1.60	A	2-635	[»]

ModBase

Search...

Protein family/group databases

CAZy

GH33. Glycoside Hydrolase Family 33.

Family and domain databases

InterPro

IPR013320. ConA-like_subgrp.
IPR008377. Sialidase_trypan.
[Graphical view]

Gene3D

G3DSA:2.60.120.200. ConA_like_subgrp. 1 hit.

PRINTS

PR01803. TCSIALIDASE.

ProtoNet

Search...

Entry information

Entry name

Q26966_TRYCR

Accession

Primary (citable) accession number: Q26966

Entry history

Integrated into UniProtKB/TrEMBL:	November 1, 1996
Last sequence update:	November 1, 1996
Last modified:	June 16, 2009
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)