Q26964 (Q26964_TRYCR) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Trans-sialidase EMBL BAA09334.1

Gene names

Name:

TCTS-154 EMBL BAA09334.1

Organism

Trypanosoma cruzi EMBL BAA09334.1

Taxonomic identifier

5693 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Euglenozoa › Kinetoplastida › Trypanosomatidae › Trypanosoma › Schizotrypanum

Protein attributes

Sequence length	1060 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

Ontologies

Keywords
Technical term	3D-structure PDB 3B69
Gene Ontology (GO)
Biological_process	pathogenesis Inferred from electronic annotation. Source: InterPro
Molecular_function	exo-alpha-sialidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q26964 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: EBD146AD6DD26288	FASTA	1,060	110,104
	10 20 30 40 50 60 MGKTVVGASR MFWLMFFVPL LLALCPSEPA HALAPGSSRV ELFKRQSSKV PFEKGGKVTE 70 80 90 100 110 120 RVVHSFRLPA LVNVDGVMVA IADARYETSN DNSLIDTVAK YSVDDGETWE TQIAIKNSRA 130 140 150 160 170 180 SSVSRVVDPT VIVKGNKLYV LVGSYNSSRS YWTSHGDARD WDILLAVGEV TKSTAGGKIT 190 200 210 220 230 240 ASIKWGSPVS LKEFFPAEME GMHTNQFLGG AGVAIVASNG NLVYPVQVTN KKKQVFSKIF 250 260 270 280 290 300 YSEDEGKTWK FGEGRSDFGC SEPVALEWEG KLIINTRVDY RRRLVYESSD MGNSWVEAVG 310 320 330 340 350 360 TLSRVWGPSP KSNQPGSQSS FTAVTIEGMR VMLFTHPLNF KGRWLRDRLN LWLTDNQRIY 370 380 390 400 410 420 NVGQVSIGDE NSAYSSVLYK DDKLYCLHEI NSNEVYSLVF ARLVGELRII KSVLQSWKNW 430 440 450 460 470 480 DSHLSSICTP ADPAASSSER GCGPAVTTVG LVGFLSHSAT KTEWEDAYRC VNASTANAER 490 500 510 520 530 540 VPNGLKFAGV GGGALWPVSQ QGQNQRYHFA NHAFTLVASV TIHEVPSVAS PLLGASLDSS 550 560 570 580 590 600 GGKKLLGLSY DEKHQWQPIY GSTPVTPTGS WEMGKRYHVV LTMANKIGSV YIDGEPLEGS 610 620 630 640 650 660 GQTVVPDGRT PDISHFYVGG YGRSDMPTIS HVTVNNVLLY NRQLNAEEIR TLFLSQDLIG 670 680 690 700 710 720 TEAHMGSSSG SSAHSTPSTP ADNGAHSTPS TPADSSAHST PSTPADSSAH STPSAPGDNG 730 740 750 760 770 780 AHSTPSTPGD SSAHSTPSTP ADNGAHSTPS APADSNAHST PSTPADNGAH STPSTPADNG 790 800 810 820 830 840 AHSTPSTPGD NGAHSTPSTP GDSSAHSTPS TPADNGAHST PSAPADSNAH STPSTPGDNG 850 860 870 880 890 900 AHSTPSAPAD SNAHSTPSTP ADSSAHSTPS APGDNGAHST PSAPADSSAH STPSAPGDNG 910 920 930 940 950 960 AHSTPSAPAD NGAHSTPSAP GDSNAHSTPS TPADSSAHST PSTPADSSAH STPSAPGDNG 970 980 990 1000 1010 1020 AHSTPSAPAD SSAHSTPSIP GDSSAHSTPS APADSSAHST PSAPGDNGAH STPSTPADNG 1030 1040 1050 1060 ANGTVLILHD GAAFSAFSGG GLLLCAGALL LHVFVMAVFF

References

[1]	"Only some members of a gene family in Trypanosoma cruzi encode proteins that express both trans-sialidase and neuraminidase activities." Uemura H., Schenkman S., Nussenzweig V., Eichinger D. EMBO J. 11:3837-3844(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE OF 178-378. Strain: Berkeley EMBL BAA09334.1.
[2]	"Isolation and expression of an open reading frame encoding sialidase from Trypanosoma rangeli." Smith L.E., Uemura H., Eichinger D. Mol. Biochem. Parasitol. 79:21-33(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: Berkeley EMBL BAA09334.1.
[3]	"A new generation of specific Trypanosoma cruzi trans-sialidase inhibitors." Buchini S., Buschiazzo A., Withers S.G. Angew. Chem. Int. Ed. 47:2700-2703(2008) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.67 ANGSTROMS) OF 33-665.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

D50685 Genomic DNA. Translation: BAA09334.1.

PIR

S28409.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3B69	X-ray	1.67	A	33-665	[»]

ProteinModelPortal

Q26964.

SMR

Q26964. Positions 33-665.

ModBase

Search...

Protein family/group databases

CAZy

GH33. Glycoside Hydrolase Family 33.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Family and domain databases

Gene3D

2.120.10.10. 1 hit.
2.60.120.200. 1 hit.

InterPro

IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR008377. Sialidase_trypan.
IPR011040. Sialidases.
[Graphical view]

PRINTS

PR01803. TCSIALIDASE.

SUPFAM

SSF49899. ConA_like_lec_gl. 1 hit.
SSF50939. Sialidase. 1 hit.

ProtoNet

Search...

Other

EvolutionaryTrace

Q26964.

Entry information

Entry name

Q26964_TRYCR

Accession

Primary (citable) accession number: Q26964

Entry history

Integrated into UniProtKB/TrEMBL:	November 1, 1996
Last sequence update:	November 1, 1996
Last modified:	April 3, 2013
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)