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Protein
Submitted name:

Trans-sialidase

Gene

TCTS-154

Organism
Trypanosoma cruzi
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

SABIO-RKQ26964.

Protein family/group databases

CAZyiGH33. Glycoside Hydrolase Family 33.

Names & Taxonomyi

Protein namesi
Submitted name:
Trans-sialidaseImported
Gene namesi
Name:TCTS-154Imported
OrganismiTrypanosoma cruziImported
Taxonomic identifieri5693 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosomaSchizotrypanum

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1036 – 105924HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence analysisAdd
BLAST
Chaini24 – 10601037Sequence analysisPRO_5004203352Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi428 ↔ 442Combined sources

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3B69X-ray1.67A33-665[»]
ProteinModelPortaliQ26964.
SMRiQ26964. Positions 33-665.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ26964.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini69 – 389321SialidasesInterPro annotationAdd
BLAST

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Family and domain databases

Gene3Di2.120.10.10. 1 hit.
2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR026856. Sialidase_fam.
IPR008377. Sialidase_trypan.
IPR011040. Sialidases.
[Graphical view]
PANTHERiPTHR10628. PTHR10628. 1 hit.
PfamiPF13859. BNR_3. 1 hit.
[Graphical view]
PRINTSiPR01803. TCSIALIDASE.
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF50939. SSF50939. 1 hit.

Sequencei

Sequence statusi: Complete.

Q26964-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKTVVGASR MFWLMFFVPL LLALCPSEPA HALAPGSSRV ELFKRQSSKV
60 70 80 90 100
PFEKGGKVTE RVVHSFRLPA LVNVDGVMVA IADARYETSN DNSLIDTVAK
110 120 130 140 150
YSVDDGETWE TQIAIKNSRA SSVSRVVDPT VIVKGNKLYV LVGSYNSSRS
160 170 180 190 200
YWTSHGDARD WDILLAVGEV TKSTAGGKIT ASIKWGSPVS LKEFFPAEME
210 220 230 240 250
GMHTNQFLGG AGVAIVASNG NLVYPVQVTN KKKQVFSKIF YSEDEGKTWK
260 270 280 290 300
FGEGRSDFGC SEPVALEWEG KLIINTRVDY RRRLVYESSD MGNSWVEAVG
310 320 330 340 350
TLSRVWGPSP KSNQPGSQSS FTAVTIEGMR VMLFTHPLNF KGRWLRDRLN
360 370 380 390 400
LWLTDNQRIY NVGQVSIGDE NSAYSSVLYK DDKLYCLHEI NSNEVYSLVF
410 420 430 440 450
ARLVGELRII KSVLQSWKNW DSHLSSICTP ADPAASSSER GCGPAVTTVG
460 470 480 490 500
LVGFLSHSAT KTEWEDAYRC VNASTANAER VPNGLKFAGV GGGALWPVSQ
510 520 530 540 550
QGQNQRYHFA NHAFTLVASV TIHEVPSVAS PLLGASLDSS GGKKLLGLSY
560 570 580 590 600
DEKHQWQPIY GSTPVTPTGS WEMGKRYHVV LTMANKIGSV YIDGEPLEGS
610 620 630 640 650
GQTVVPDGRT PDISHFYVGG YGRSDMPTIS HVTVNNVLLY NRQLNAEEIR
660 670 680 690 700
TLFLSQDLIG TEAHMGSSSG SSAHSTPSTP ADNGAHSTPS TPADSSAHST
710 720 730 740 750
PSTPADSSAH STPSAPGDNG AHSTPSTPGD SSAHSTPSTP ADNGAHSTPS
760 770 780 790 800
APADSNAHST PSTPADNGAH STPSTPADNG AHSTPSTPGD NGAHSTPSTP
810 820 830 840 850
GDSSAHSTPS TPADNGAHST PSAPADSNAH STPSTPGDNG AHSTPSAPAD
860 870 880 890 900
SNAHSTPSTP ADSSAHSTPS APGDNGAHST PSAPADSSAH STPSAPGDNG
910 920 930 940 950
AHSTPSAPAD NGAHSTPSAP GDSNAHSTPS TPADSSAHST PSTPADSSAH
960 970 980 990 1000
STPSAPGDNG AHSTPSAPAD SSAHSTPSIP GDSSAHSTPS APADSSAHST
1010 1020 1030 1040 1050
PSAPGDNGAH STPSTPADNG ANGTVLILHD GAAFSAFSGG GLLLCAGALL
1060
LHVFVMAVFF
Length:1,060
Mass (Da):110,104
Last modified:November 1, 1996 - v1
Checksum:iEBD146AD6DD26288
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50685 Genomic DNA. Translation: BAA09334.1.
PIRiS28409.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50685 Genomic DNA. Translation: BAA09334.1.
PIRiS28409.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3B69X-ray1.67A33-665[»]
ProteinModelPortaliQ26964.
SMRiQ26964. Positions 33-665.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiGH33. Glycoside Hydrolase Family 33.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

SABIO-RKQ26964.

Miscellaneous databases

EvolutionaryTraceiQ26964.

Family and domain databases

Gene3Di2.120.10.10. 1 hit.
2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR026856. Sialidase_fam.
IPR008377. Sialidase_trypan.
IPR011040. Sialidases.
[Graphical view]
PANTHERiPTHR10628. PTHR10628. 1 hit.
PfamiPF13859. BNR_3. 1 hit.
[Graphical view]
PRINTSiPR01803. TCSIALIDASE.
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF50939. SSF50939. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Only some members of a gene family in Trypanosoma cruzi encode proteins that express both trans-sialidase and neuraminidase activities."
    Uemura H., Schenkman S., Nussenzweig V., Eichinger D.
    EMBO J. 11:3837-3844(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BerkeleyImported.
  2. "Isolation and expression of an open reading frame encoding sialidase from Trypanosoma rangeli."
    Smith L.E., Uemura H., Eichinger D.
    Mol. Biochem. Parasitol. 79:21-33(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BerkeleyImported.
  3. "A new generation of specific Trypanosoma cruzi trans-sialidase inhibitors."
    Buchini S., Buschiazzo A., Withers S.G.
    Angew. Chem. Int. Ed. 47:2700-2703(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.67 ANGSTROMS) OF 33-665, DISULFIDE BONDS.

Entry informationi

Entry nameiQ26964_TRYCR
AccessioniPrimary (citable) accession number: Q26964
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: April 13, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.