Reviewed, UniProtKB/Swiss-Prot Q26896 (CYAA_TRYCO)

Names and origin

Protein names	Recommended name:     Receptor-type adenylate cyclase     EC=4.6.1.1 Alternative name(s):     ATP pyrophosphate-lyase     Adenylyl cyclase
Organism	Trypanosoma congolense
Taxonomic identifier	5692 [NCBI]
Taxonomic lineage	Eukaryota › Euglenozoa › Kinetoplastida › Trypanosomatidae › Trypanosoma › Nannomonas

Protein attributes

Sequence length	745 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Could act as a receptor for a unknown ligand.
Catalytic activity	ATP = 3',5'-cyclic AMP + diphosphate.
Cofactor	Binds 1 magnesium ion per subunit By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the adenylyl cyclase class-3 family. Contains 1 guanylate cyclase domain.

Ontologies

Keywords
Biological process	cAMP biosynthesis
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Lyase Receptor
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	cAMP biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW intracellular signaling cascade Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW adenylate cyclase activity Inferred from electronic annotation. Source: EC magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW receptor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – 745	›745	Receptor-type adenylate cyclase		PRO_0000195740
Regions
	Topological domain	‹1 – 341	›341	Extracellular Potential
	Transmembrane	342 – 362	21	Potential
	Topological domain	363 – 745	383	Cytoplasmic Potential
	Domain	384 – 538	155	Guanylate cyclase
Sites
	Metal binding	389	1	Magnesium By similarity
	Metal binding	432	1	Magnesium By similarity
Amino acid modifications
	Glycosylation	15	1	N-linked (GlcNAc...) Potential
	Glycosylation	50	1	N-linked (GlcNAc...) Potential
	Glycosylation	189	1	N-linked (GlcNAc...) Potential
	Glycosylation	312	1	N-linked (GlcNAc...) Potential
Experimental info
	Non-terminal residue	1	1

Sequences

	Sequence		Length	Mass (Da)
	Q26896-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 160FA017769A147E	FASTA	745	81,653
	10 20 30 40 50 60 GELGQTDRFF VRIINTTVSE AAHTLTSEKE ERIVTAVFGI VSEDMLDTPN TTFIDPLRLS 70 80 90 100 110 120 PRLNKFRRNV IHLSPTLEQQ LFVLASHLQS IGSSKALAVI CSEESNDIGD AVRRTLAEFD 130 140 150 160 170 180 VPLESVRTRM DGEALDGYLP AGGDVFVIGL SVADVEVIAK KLEKHSALRV IVLFSDVALL 190 200 210 220 230 240 YDVFSVAFNG TTGCERLVFA TNLPHWSDAT PSSVTVQRFH TALSDPKMWT PLSLLAFATG 250 260 270 280 290 300 RLMQSILPRM EKVGSDTLAN FFYADSSVVV DGMRYGVFDD IECKPAGSDL EVCASNYGAT 310 320 330 340 350 360 QISVRSMSRT FNASIALLAE PMTPSMRFRD PNEGALTRAQ LIGVVVGTIF AVLLLLALGI 370 380 390 400 410 420 VLCVALRNTR DNDSAPKEFT DPVTLIFTDI ESSTALWAAH PGMMADAVAT HHRLIRSLIA 430 440 450 460 470 480 LYGAYEVKTV GDSFMIACRS AFAAVELARD LQLTLVHHDW GTVAIDESYR KFEEERAVED 490 500 510 520 530 540 SDYAPPTARL DSAVYCKLWN GLRVRAGIHT GLCDIAHDEV TKGYDYYGRT PNLAARTESA 550 560 570 580 590 600 ANGGQVLVTG ATYYSLSVAE RARLDATPIG PVPLRGVPEP VEMYQLNAVS GRTFAALRLD 610 620 630 640 650 660 RKVDLINDES DATDGVYSEC GSTHGELSHS AQTIMMVLCA LIGTFTAPQR EKLLIPFCER 670 680 690 700 710 720 WRVSLPRKTG TAWDENYSRE VVRCIALKVG HVINFDSSAY DFDDLPVSMR RQSSFIVLSH 730 740 QLMESIQETT QQGPSGSDEV ARTCV

References

[1]	"Families of adenylate cyclase genes in Trypanosoma brucei." Alexandre S., Paindavoine P., Hanocq-Quertier J., Paturiaux-Hanocq F., Tebabi P., Pays E. Mol. Biochem. Parasitol. 77:173-182(1996) [PubMed: 8813663] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	Z67964 mRNA. Translation: CAA91903.1.
3D structure databases
HSSP	HSSP built from PDB template 1FX4 based on UniProtKB Q99280.
SMR	Q26896. Positions 371-602.
ModBase	Search...
Enzyme and pathway databases
BRENDA	4.6.1.1. 95989.
Family and domain databases
InterPro	IPR001054. A/G_cyclase. [Graphical view]
Gene3D	G3DSA:3.30.70.1230. A/G_cyclase. 1 hit.
Pfam	PF00211. Guanylate_cyc. 1 hit. [Graphical view]
SMART	SM00044. CYCc. 1 hit. [Graphical view]
PROSITE	PS50125. GUANYLATE_CYCLASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CYAA_TRYCO

Accession

Primary (citable) accession number: Q26896

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	November 1, 1996
Last modified:	October 13, 2009
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)