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Protein
Submitted name:

Cruzipain

Gene
N/A
Organism
Trypanosoma cruzi
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol proteaseSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
CruzipainImported
OrganismiTrypanosoma cruziImported
Taxonomic identifieri5693 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosomaSchizotrypanum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626UniRule annotationAdd
BLAST
Chaini27 – 467441UniRule annotationPRO_5005400171Add
BLAST

Proteomic databases

PaxDbiQ26884.

Structurei

3D structure databases

ProteinModelPortaliQ26884.
SMRiQ26884. Positions 123-337.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini38 – 9457Inhibitor_I29InterPro annotationAdd
BLAST
Domaini123 – 335213Pept_C1InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C1 family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalUniRule annotation

Phylogenomic databases

eggNOGiKOG1542. Eukaryota.
COG4870. LUCA.

Family and domain databases

InterProiIPR021981. DUF3586.
IPR025661. Pept_asp_AS.
IPR000169. Pept_cys_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
IPR013201. Prot_inhib_I29.
[Graphical view]
PANTHERiPTHR12411. PTHR12411. 1 hit.
PfamiPF12131. DUF3586. 1 hit.
PF08246. Inhibitor_I29. 1 hit.
PF00112. Peptidase_C1. 1 hit.
[Graphical view]
PRINTSiPR00705. PAPAIN.
SMARTiSM00848. Inhibitor_I29. 1 hit.
SM00645. Pept_C1. 1 hit.
[Graphical view]
PROSITEiPS00640. THIOL_PROTEASE_ASN. 1 hit.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q26884-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGWARALSL AAVLVVMACL VPAATASLHA EETLASQFAE FKQKHGRVYG
60 70 80 90 100
SAAEEAFRLS VFRENLFLAR LHAAANPHAT FGVTAFSDLT REEFRSRYHN
110 120 130 140 150
GAAHFAAAQE RARVPVNVEV VGAPAAVDWR ARGAVTAVKD QGQCGSCWAF
160 170 180 190 200
SAIGNVECQW FLAGHPLTNL SEQMLVSCDK TDSGCGGGLM NNAFEWIVQE
210 220 230 240 250
NNGAVYTEDS YPYASGEGIS PPCTTSGHTV GATITGHVEL PQDEAQIAAW
260 270 280 290 300
LAVNGPVAVA VDASSWMTYT GGVMTSCVSE QLDHGVLLVG YNDSAAVPYW
310 320 330 340 350
VIKNSWTTQW GEDGYIRIAK GSNQCLVKEE ASSAVVGGPG PTPEPTTTTT
360 370 380 390 400
TSAPGPSPSY FVQMSCTDAA CIVGCENVTL PTGQCLLTTS GVSAIVTCGA
410 420 430 440 450
ETLTEEVFLT STHCSGPSVR SSVPLNKCNR LLRGSVEFFC GSSSSGRLAD
460
VDRQRRYQPY HSRHRRL
Length:467
Mass (Da):49,636
Last modified:November 1, 1996 - v1
Checksum:i4093E67B1B433470
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U41454 Genomic DNA. Translation: AAB41119.1.
PIRiA44938.
A45629.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U41454 Genomic DNA. Translation: AAB41119.1.
PIRiA44938.
A45629.

3D structure databases

ProteinModelPortaliQ26884.
SMRiQ26884. Positions 123-337.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiQ26884.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG1542. Eukaryota.
COG4870. LUCA.

Family and domain databases

InterProiIPR021981. DUF3586.
IPR025661. Pept_asp_AS.
IPR000169. Pept_cys_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
IPR013201. Prot_inhib_I29.
[Graphical view]
PANTHERiPTHR12411. PTHR12411. 1 hit.
PfamiPF12131. DUF3586. 1 hit.
PF08246. Inhibitor_I29. 1 hit.
PF00112. Peptidase_C1. 1 hit.
[Graphical view]
PRINTSiPR00705. PAPAIN.
SMARTiSM00848. Inhibitor_I29. 1 hit.
SM00645. Pept_C1. 1 hit.
[Graphical view]
PROSITEiPS00640. THIOL_PROTEASE_ASN. 1 hit.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ26884_TRYCR
AccessioniPrimary (citable) accession number: Q26884
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: May 11, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.