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Reviewed, UniProtKB/Swiss-Prot Q26783 (NDUS7_TRYBB)

Last modified November 25, 2008. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial
    EC=1.6.5.3
    EC=1.6.99.3
Alternative name(s):
    NADH-ubiquinone oxidoreductase 20 kDa subunit
    Complex I-20kD
      Short name=CI-20kD
Gene names
Name: NDHK
OrganismTrypanosoma brucei brucei
Taxonomic identifier5702 [NCBI]
Taxonomic lineageEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosoma

Protein attributes

Sequence length202 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity.

Catalytic activity

NADH + ubiquinone = NAD(+) + ubiquinol.

NADH + acceptor = NAD(+) + reduced acceptor.

Cofactor

Binds 1 4Fe-4S cluster By similarity.

Subunit structure

Complex I is composed of 45 different subunits This is a component of the iron-sulfur (IP) fragment of the enzyme By similarity.

Subcellular location

MitochondrionBy similarity.

Sequence similarities

Belongs to the complex I 20 kDa subunit family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 5656Mitochondrion Potential
Chain57 – 202146NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial
PRO_0000020031

Sites

Metal binding771Iron-sulfur (4Fe-4S) Potential
Metal binding781Iron-sulfur (4Fe-4S) Potential
Metal binding1421Iron-sulfur (4Fe-4S) Potential
Metal binding1721Iron-sulfur (4Fe-4S) Potential

Sequences

Sequence LengthMass (Da)Tools
Q26783-1 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 58CC3911E359E50D

FASTA20223,077
        10         20         30         40         50         60 
MLRRTSFNFT GRAMISRGSP EWSHRLDLKK GKKTTMMHKL GTSKPNNALQ YAQMTLHDLT 

        70         80         90        100        110        120 
EWCLAYSPWP LTFGLACCAV EMMHAYASRY DLDRFGIVPR PTPRQAEIII VSGTVTNKMA 

       130        140        150        160        170        180 
PILRNIYVQM VNPKWVISMG SCANGGGYYH FSYAVLRGCE RAIPVDFWIP GCPPSAESLV 

       190        200 
FCLHTLQKKI RWHEIQKYSV RD 

« Hide

References

[1]"Characterization of a Trypanosoma brucei nuclear gene encoding a protein homologous to a subunit of bovine NADH:ubiquinone oxidoreductase (complex I)."
Peterson G.C., Souza A.E., Parsons M.
Mol. Biochem. Parasitol. 58:63-70(1993) [PubMed: 8459836] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: EATRO 164.

Cross-references

Sequence databases

L00585 Genomic DNA. Translation: AAA30217.1.

3D structure databases

ModBaseSearch...

Family and domain databases

InterProIPR006138. NADH_DHase_20kDa_su.
IPR014406. NiFe_hyd_3_ssu/Q_oxred_NuoB.
IPR006137. OxRdtase_q6.
[Graphical view]
PANTHERPTHR11995:SF2. NADH_DH_20kDa. 1 hit.
PTHR11995. NiFe_hyd_3_ssu/Q_oxred_NuoB. 1 hit.
PfamPF01058. Oxidored_q6. 1 hit.
[Graphical view]
TIGRFAMsTIGR01957. nuoB_fam. 1 hit.
PROSITEPS01150. COMPLEX1_20K. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNDUS7_TRYBB
AccessionPrimary (citable) accession number: Q26783
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: November 25, 2008
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents