ID   CYA4_TRYBB              Reviewed;        1235 AA.
AC   Q26721;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   16-JUN-2009, entry version 50.
DE   RecName: Full=Receptor-type adenylate cyclase ESAG 4;
DE            EC=4.6.1.1;
DE   AltName: Full=ATP pyrophosphate-lyase;
DE   AltName: Full=Adenylyl cyclase;
DE   AltName: Full=Expression site-associated protein 4;
DE   AltName: Full=Antigen 4;
GN   Name=ESAG4;
OS   Trypanosoma brucei brucei.
OC   Eukaryota; Euglenozoa; Kinetoplastida; Trypanosomatidae; Trypanosoma.
OX   NCBI_TaxID=5702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=EATRO 1125;
RX   MEDLINE=89249348; PubMed=2720787; DOI=10.1016/0092-8674(89)90798-8;
RA   Pays E., Tebabi P., Pays A., Coquelet H., Revelard P., Salmon D.,
RA   Steinert M.;
RT   "The genes and transcripts of an antigen gene expression site from T.
RT   brucei.";
RL   Cell 57:835-845(1989).
CC   -!- FUNCTION: Could act as a receptor for a unknown ligand.
CC   -!- CATALYTIC ACTIVITY: ATP = 3',5'-cyclic AMP + diphosphate.
CC   -!- COFACTOR: Binds 1 magnesium ion per subunit (By similarity).
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein
CC       (Potential).
CC   -!- SIMILARITY: Belongs to the adenylyl cyclase class-3 family.
CC   -!- SIMILARITY: Contains 1 guanylate cyclase domain.
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DR   EMBL; M33720; AAA30158.1; -; Genomic_DNA.
DR   PIR; D32433; D32433.
DR   HSSP; Q99280; 1FX4.
DR   SMR; Q26721; 898-1121.
DR   BRENDA; 4.6.1.1; 74165.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004016; F:adenylate cyclase activity; IEA:EC.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004872; F:receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0006171; P:cAMP biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0007242; P:intracellular signaling cascade; IEA:InterPro.
DR   InterPro; IPR001054; A/G_cyclase.
DR   Gene3D; G3DSA:3.30.70.1230; A/G_cyclase; 1.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   SMART; SM00044; CYCc; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; cAMP biosynthesis; Glycoprotein; Lyase; Magnesium;
KW   Membrane; Metal-binding; Nucleotide-binding; Receptor; Transmembrane.
FT   CHAIN         1   1235       Receptor-type adenylate cyclase ESAG 4.
FT                                /FTId=PRO_0000195736.
FT   TOPO_DOM      1     32       Cytoplasmic (Potential).
FT   TRANSMEM     33     53       Potential.
FT   TOPO_DOM     54    858       Extracellular (Potential).
FT   TRANSMEM    859    879       Potential.
FT   TOPO_DOM    880   1235       Cytoplasmic (Potential).
FT   DOMAIN      900   1054       Guanylate cyclase.
FT   COMPBIAS     46     50       Poly-Leu.
FT   METAL       905    905       Magnesium (By similarity).
FT   METAL       948    948       Magnesium (By similarity).
FT   CARBOHYD     63     63       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD     90     90       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD     97     97       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    362    362       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    531    531       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    566    566       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    705    705       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    830    830       N-linked (GlcNAc...) (Potential).
SQ   SEQUENCE   1235 AA;  136458 MW;  CCAC3E2D78D3DC7A CRC64;
     MNMLHLSDRN ASLAPSGGEH SLPTGGAVCR DAMDILPVIL RAPVALLLLL VVLPQLSVGA
     EANVTVKVLS ATWNWYMPRK YVTAINAGFN ASLKSRNWTV AGSVNVQVVY PSNLDLMPED
     FIKKQLELET DQNKIVIVYG PLGDKSVMHS IPHLMNHRVV AFGLITGSTF IRQWNPYLYF
     LRADPAAETL VLIRYSLCQL RVLRLGFMYL QGVHYGDEEY ALTVNVMSRM GYELHGVFTV
     MSPDGKPAPD AEFKEVFERF ATALPQAIIV FGAPVDDTAK FLMMMAVDER IARSYILSPS
     SVQLSLIEMW QLALEAAGAS FAPGQLLFTG TNPLAKDSQY TAIKRFQEVM SEYLKAHVGE
     TNITEADYFL THDLEGELMV YGWISGEVLS QALSNLEWLK DRATFVRSLY DQRRYVINDI
     VIGDYGGTCE GDAAKHGATC ECNQGSKAVY VKEMLENGQK TSVRSGFTVL KASLCYTDSS
     ELHGPLDGLV VFMKDDDIAS KAAALWQKGT SHLVGKGDLG YSDRFFLHAF NTTIAEAAND
     LRRDQGERIV TAVFGPVTEA MLDTPNITFI DPLELKPRLN KFRRNVIHLS PTLEQQLYVL
     SSYLAGAGVG NVDAVICSNE ADGIADFLRS SLTEFAVSLR SAVIREDGED VGKYLPMSGT
     VFVIGLSVPD VKEIARKLEE RNDLRVIVLF GEFSFLYDLF ATALNNTAGA ARLVFATSLP
     HWGDTETSSK TAQLFHDVEK DSRLWTPLSV LAFATGRLMR VILLHVEEMS PETLVNFFYT
     DSSIVSDDMR YGVFDDTKCV DTANKLSKNG CASNYGATQI SVWSMARALN ASIPPLTNPM
     TPSMTFRNSN AGRISGASLV GIIIGGALAL FLVVALGVVP YFFLRNTVIT ICTKDDRPVT
     LIFTDIESST ALWAAHPEVM PDAVATHHRL IRTLISKYEC YEVKTVGDSF MIASKSPFAA
     VQLAQELQLC FLHHDWGTNA IDESYQQFEQ QRAEDDSDYT PPTARLDPKV YSRLWNGLRV
     RVGIHTGLCD IRRDEVTKGY DYYGRTSNMA ARTESVANGG QVLMTHAAYM SLSAEERQQI
     DVTALGDVPL RGVPKPVEMY RLNAVPGRTF SVLRLELELL NDDEDQTTTS CSDHSSSRTD
     LSVAAQTIAA SLQSLLGTFT PAQRQKALIP FCERWRVPLP QKVGNVWDDD GCQEVVRRVA
     AKVGRVMDFG TRKPSSSVTS WKGVEVSSQV EERLL
//