ID FCA2_TRYBB Reviewed; 218 AA. AC Q26680; DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1997, sequence version 1. DT 22-FEB-2023, entry version 96. DE RecName: Full=Flagellar calcium-binding protein TB-24; DE AltName: Full=24 kDa calcimedin; DE AltName: Full=24 kDa calflagin; OS Trypanosoma brucei brucei. OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina; OC Trypanosomatida; Trypanosomatidae; Trypanosoma. OX NCBI_TaxID=5702; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=427; RX PubMed=7818488; DOI=10.1042/bj3040833; RA Wu Y., Deford J., Benjamin R., Lee M.G.-S., Ruben L.; RT "The gene family of EF-hand calcium-binding proteins from the flagellum of RT Trypanosoma brucei."; RL Biochem. J. 304:833-841(1994). CC -!- FUNCTION: May contribute to the rapid motility of the trypanosomes, CC playing a role either in flagellar structure or in calcium metabolism. CC Could alternate between a GDP-bound inactive form to a calcium/GTP- CC bound active form. CC -!- SUBCELLULAR LOCATION: Cell projection, cilium, flagellum. CC -!- DOMAIN: This protein has four EF-hand domains, three of which may be CC functional calcium-binding sites. CC -!- SIMILARITY: Belongs to the calflagin family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U06644; AAB40004.1; -; Genomic_DNA. DR PIR; S53354; S53354. DR PDB; 2LVV; NMR; -; A=1-218. DR PDBsum; 2LVV; -. DR AlphaFoldDB; Q26680; -. DR BMRB; Q26680; -. DR SMR; Q26680; -. DR SwissPalm; Q26680; -. DR GO; GO:0031514; C:motile cilium; IEA:UniProtKB-SubCell. DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro. DR CDD; cd00051; EFh; 1. DR DisProt; DP01669; -. DR Gene3D; 1.10.238.10; EF-hand; 1. DR InterPro; IPR003299; Calflagin-bd. DR InterPro; IPR011992; EF-hand-dom_pair. DR InterPro; IPR018247; EF_Hand_1_Ca_BS. DR InterPro; IPR002048; EF_hand_dom. DR Pfam; PF13499; EF-hand_7; 1. DR PRINTS; PR01362; CALFLAGIN. DR SMART; SM00054; EFh; 3. DR SUPFAM; SSF47473; EF-hand; 1. DR PROSITE; PS00018; EF_HAND_1; 2. DR PROSITE; PS50222; EF_HAND_2; 3. PE 1: Evidence at protein level; KW 3D-structure; Calcium; Cell projection; Cilium; Flagellum; Metal-binding; KW Repeat. FT CHAIN 1..218 FT /note="Flagellar calcium-binding protein TB-24" FT /id="PRO_0000073737" FT DOMAIN 48..83 FT /note="EF-hand 1" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448" FT DOMAIN 84..119 FT /note="EF-hand 2" FT /evidence="ECO:0000305" FT DOMAIN 130..165 FT /note="EF-hand 3" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448" FT DOMAIN 167..202 FT /note="EF-hand 4" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448" FT REGION 1..27 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1..16 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT BINDING 61 FT /ligand="Ca(2+)" FT /ligand_id="ChEBI:CHEBI:29108" FT /ligand_label="1" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448" FT BINDING 63 FT /ligand="Ca(2+)" FT /ligand_id="ChEBI:CHEBI:29108" FT /ligand_label="1" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448" FT BINDING 65 FT /ligand="Ca(2+)" FT /ligand_id="ChEBI:CHEBI:29108" FT /ligand_label="1" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448" FT BINDING 67 FT /ligand="Ca(2+)" FT /ligand_id="ChEBI:CHEBI:29108" FT /ligand_label="1" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448" FT BINDING 72 FT /ligand="Ca(2+)" FT /ligand_id="ChEBI:CHEBI:29108" FT /ligand_label="1" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448" FT BINDING 143 FT /ligand="Ca(2+)" FT /ligand_id="ChEBI:CHEBI:29108" FT /ligand_label="2" FT /evidence="ECO:0000305" FT BINDING 145 FT /ligand="Ca(2+)" FT /ligand_id="ChEBI:CHEBI:29108" FT /ligand_label="2" FT /evidence="ECO:0000305" FT BINDING 147 FT /ligand="Ca(2+)" FT /ligand_id="ChEBI:CHEBI:29108" FT /ligand_label="2" FT /evidence="ECO:0000305" FT BINDING 154 FT /ligand="Ca(2+)" FT /ligand_id="ChEBI:CHEBI:29108" FT /ligand_label="2" FT /evidence="ECO:0000305" FT BINDING 180 FT /ligand="Ca(2+)" FT /ligand_id="ChEBI:CHEBI:29108" FT /ligand_label="3" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448" FT BINDING 182 FT /ligand="Ca(2+)" FT /ligand_id="ChEBI:CHEBI:29108" FT /ligand_label="3" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448" FT BINDING 184 FT /ligand="Ca(2+)" FT /ligand_id="ChEBI:CHEBI:29108" FT /ligand_label="3" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448" FT BINDING 191 FT /ligand="Ca(2+)" FT /ligand_id="ChEBI:CHEBI:29108" FT /ligand_label="3" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448" FT STRAND 20..22 FT /evidence="ECO:0007829|PDB:2LVV" FT HELIX 27..40 FT /evidence="ECO:0007829|PDB:2LVV" FT HELIX 47..60 FT /evidence="ECO:0007829|PDB:2LVV" FT HELIX 61..63 FT /evidence="ECO:0007829|PDB:2LVV" FT HELIX 71..79 FT /evidence="ECO:0007829|PDB:2LVV" FT TURN 84..86 FT /evidence="ECO:0007829|PDB:2LVV" FT STRAND 87..89 FT /evidence="ECO:0007829|PDB:2LVV" FT HELIX 91..108 FT /evidence="ECO:0007829|PDB:2LVV" FT HELIX 119..142 FT /evidence="ECO:0007829|PDB:2LVV" FT HELIX 152..165 FT /evidence="ECO:0007829|PDB:2LVV" FT HELIX 173..179 FT /evidence="ECO:0007829|PDB:2LVV" FT HELIX 189..204 FT /evidence="ECO:0007829|PDB:2LVV" FT STRAND 209..211 FT /evidence="ECO:0007829|PDB:2LVV" SQ SEQUENCE 218 AA; 24252 MW; 041152AC2BDD6DDB CRC64; MGCSASKDTT NSKDGAASKG GKDGKTTADR KVAWERIRCA IPRDKDAESK SRRIELFKQF DTNGTGKLGF REVLDGCYGI LKLDEFTTHL PDIVQRAFDK AKDLGNKVKG VGEEDLVEFL EFRLMLCYIY DIFELTVMFD TMDKDGSLLL ELQEFKEALP KLKEWGVDIT DATTVFNEID TNGSGVVTFD EFSCWAVTKK LQVCGDPDGE ENGANEGN //