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Q26680 (FCA2_TRYBB) Reviewed, UniProtKB/Swiss-Prot

Last modified September 18, 2013. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Flagellar calcium-binding protein TB-24
Alternative name(s):
24 kDa calcimedin
24 kDa calflagin
OrganismTrypanosoma brucei brucei
Taxonomic identifier5702 [NCBI]
Taxonomic lineageEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosoma

Protein attributes

Sequence length218 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May contribute to the rapid motility of the trypanosomes, playing a role either in flagellar structure or in calcium metabolism. Could alternate between a GDP-bound inactive form to a calcium/GTP-bound active form.

Subcellular location

Cell projectionciliumflagellum.

Domain

This protein has four EF-hand domains, three of which may be functional calcium-binding sites.

Sequence similarities

Belongs to the calflagin family.

Contains 4 EF-hand domains.

Ontologies

Keywords
   Cellular componentCell projection
Cilium
Flagellum
   DomainRepeat
   LigandCalcium
Metal-binding
   Technical term3D-structure
Gene Ontology (GO)
   Cellular_componentcilium

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functioncalcium ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 218218Flagellar calcium-binding protein TB-24
PRO_0000073737

Regions

Domain48 – 8336EF-hand 1
Domain84 – 11936EF-hand 2
Domain130 – 16536EF-hand 3
Domain167 – 20236EF-hand 4
Calcium binding61 – 72121 Potential
Calcium binding143 – 154122 Potential
Calcium binding180 – 191123 Potential

Secondary structure

......................... 218
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q26680 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: 041152AC2BDD6DDB

FASTA21824,252
        10         20         30         40         50         60 
MGCSASKDTT NSKDGAASKG GKDGKTTADR KVAWERIRCA IPRDKDAESK SRRIELFKQF 

        70         80         90        100        110        120 
DTNGTGKLGF REVLDGCYGI LKLDEFTTHL PDIVQRAFDK AKDLGNKVKG VGEEDLVEFL 

       130        140        150        160        170        180 
EFRLMLCYIY DIFELTVMFD TMDKDGSLLL ELQEFKEALP KLKEWGVDIT DATTVFNEID 

       190        200        210 
TNGSGVVTFD EFSCWAVTKK LQVCGDPDGE ENGANEGN 

« Hide

References

[1]"The gene family of EF-hand calcium-binding proteins from the flagellum of Trypanosoma brucei."
Wu Y., Deford J., Benjamin R., Lee M.G.-S., Ruben L.
Biochem. J. 304:833-841(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 427.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U06644 Genomic DNA. Translation: AAB40004.1.
PIRS53354.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2LVVNMR-A1-218[»]
ProteinModelPortalQ26680.
SMRQ26680. Positions 22-208.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGNOG43316.

Family and domain databases

Gene3D1.10.238.10. 2 hits.
InterProIPR003299. Calflagin-bd.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamPF13405. EF-hand_6. 1 hit.
PF13499. EF-hand_7. 1 hit.
[Graphical view]
PRINTSPR01362. CALFLAGIN.
SMARTSM00054. EFh. 3 hits.
[Graphical view]
PROSITEPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 3 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFCA2_TRYBB
AccessionPrimary (citable) accession number: Q26680
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: September 18, 2013
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references