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Q26680

- FCA2_TRYBB

UniProt

Q26680 - FCA2_TRYBB

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Protein
Flagellar calcium-binding protein TB-24
Gene
N/A
Organism
Trypanosoma brucei brucei
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

May contribute to the rapid motility of the trypanosomes, playing a role either in flagellar structure or in calcium metabolism. Could alternate between a GDP-bound inactive form to a calcium/GTP-bound active form.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi61 – 72121 Reviewed prediction
Add
BLAST
Calcium bindingi143 – 154122 Reviewed prediction
Add
BLAST
Calcium bindingi180 – 191123 Reviewed prediction
Add
BLAST

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Flagellar calcium-binding protein TB-24
Alternative name(s):
24 kDa calcimedin
24 kDa calflagin
OrganismiTrypanosoma brucei brucei
Taxonomic identifieri5702 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosoma

Subcellular locationi

GO - Cellular componenti

  1. cilium Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium, Flagellum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 218218Flagellar calcium-binding protein TB-24
PRO_0000073737Add
BLAST

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi20 – 223
Helixi27 – 4014
Helixi47 – 6014
Helixi61 – 633
Helixi71 – 799
Turni84 – 863
Beta strandi87 – 893
Helixi91 – 10818
Helixi119 – 14224
Helixi152 – 16514
Helixi173 – 1797
Helixi189 – 20416
Beta strandi209 – 2113

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2LVVNMR-A1-218[»]
ProteinModelPortaliQ26680.
SMRiQ26680. Positions 22-208.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini48 – 8336EF-hand 1
Add
BLAST
Domaini84 – 11936EF-hand 2
Add
BLAST
Domaini130 – 16536EF-hand 3
Add
BLAST
Domaini167 – 20236EF-hand 4
Add
BLAST

Domaini

This protein has four EF-hand domains, three of which may be functional calcium-binding sites.

Sequence similaritiesi

Belongs to the calflagin family.
Contains 4 EF-hand domains.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG43316.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR003299. Calflagin-bd.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13405. EF-hand_6. 1 hit.
PF13499. EF-hand_7. 1 hit.
[Graphical view]
PRINTSiPR01362. CALFLAGIN.
SMARTiSM00054. EFh. 3 hits.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q26680-1 [UniParc]FASTAAdd to Basket

« Hide

MGCSASKDTT NSKDGAASKG GKDGKTTADR KVAWERIRCA IPRDKDAESK    50
SRRIELFKQF DTNGTGKLGF REVLDGCYGI LKLDEFTTHL PDIVQRAFDK 100
AKDLGNKVKG VGEEDLVEFL EFRLMLCYIY DIFELTVMFD TMDKDGSLLL 150
ELQEFKEALP KLKEWGVDIT DATTVFNEID TNGSGVVTFD EFSCWAVTKK 200
LQVCGDPDGE ENGANEGN 218
Length:218
Mass (Da):24,252
Last modified:November 1, 1997 - v1
Checksum:i041152AC2BDD6DDB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U06644 Genomic DNA. Translation: AAB40004.1.
PIRiS53354.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U06644 Genomic DNA. Translation: AAB40004.1 .
PIRi S53354.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2LVV NMR - A 1-218 [» ]
ProteinModelPortali Q26680.
SMRi Q26680. Positions 22-208.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi NOG43316.

Family and domain databases

Gene3Di 1.10.238.10. 2 hits.
InterProi IPR003299. Calflagin-bd.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view ]
Pfami PF13405. EF-hand_6. 1 hit.
PF13499. EF-hand_7. 1 hit.
[Graphical view ]
PRINTSi PR01362. CALFLAGIN.
SMARTi SM00054. EFh. 3 hits.
[Graphical view ]
PROSITEi PS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The gene family of EF-hand calcium-binding proteins from the flagellum of Trypanosoma brucei."
    Wu Y., Deford J., Benjamin R., Lee M.G.-S., Ruben L.
    Biochem. J. 304:833-841(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 427.

Entry informationi

Entry nameiFCA2_TRYBB
AccessioniPrimary (citable) accession number: Q26680
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: September 18, 2013
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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