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Q26680

- FCA2_TRYBB

UniProt

Q26680 - FCA2_TRYBB

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Protein

Flagellar calcium-binding protein TB-24

Gene
N/A
Organism
Trypanosoma brucei brucei
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

May contribute to the rapid motility of the trypanosomes, playing a role either in flagellar structure or in calcium metabolism. Could alternate between a GDP-bound inactive form to a calcium/GTP-bound active form.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi61 – 72121PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi143 – 154122PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi180 – 191123PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Flagellar calcium-binding protein TB-24
Alternative name(s):
24 kDa calcimedin
24 kDa calflagin
OrganismiTrypanosoma brucei brucei
Taxonomic identifieri5702 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosoma

Subcellular locationi

GO - Cellular componenti

  1. motile cilium Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium, Flagellum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 218218Flagellar calcium-binding protein TB-24PRO_0000073737Add
BLAST

Structurei

Secondary structure

1
218
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi20 – 223
Helixi27 – 4014
Helixi47 – 6014
Helixi61 – 633
Helixi71 – 799
Turni84 – 863
Beta strandi87 – 893
Helixi91 – 10818
Helixi119 – 14224
Helixi152 – 16514
Helixi173 – 1797
Helixi189 – 20416
Beta strandi209 – 2113

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2LVVNMR-A1-218[»]
ProteinModelPortaliQ26680.
SMRiQ26680. Positions 22-208.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini48 – 8336EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini84 – 11936EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini130 – 16536EF-hand 3PROSITE-ProRule annotationAdd
BLAST
Domaini167 – 20236EF-hand 4PROSITE-ProRule annotationAdd
BLAST

Domaini

This protein has four EF-hand domains, three of which may be functional calcium-binding sites.

Sequence similaritiesi

Belongs to the calflagin family.Curated
Contains 4 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG43316.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR003299. Calflagin-bd.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13405. EF-hand_6. 1 hit.
PF13499. EF-hand_7. 1 hit.
[Graphical view]
PRINTSiPR01362. CALFLAGIN.
SMARTiSM00054. EFh. 3 hits.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q26680-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGCSASKDTT NSKDGAASKG GKDGKTTADR KVAWERIRCA IPRDKDAESK
60 70 80 90 100
SRRIELFKQF DTNGTGKLGF REVLDGCYGI LKLDEFTTHL PDIVQRAFDK
110 120 130 140 150
AKDLGNKVKG VGEEDLVEFL EFRLMLCYIY DIFELTVMFD TMDKDGSLLL
160 170 180 190 200
ELQEFKEALP KLKEWGVDIT DATTVFNEID TNGSGVVTFD EFSCWAVTKK
210
LQVCGDPDGE ENGANEGN
Length:218
Mass (Da):24,252
Last modified:November 1, 1997 - v1
Checksum:i041152AC2BDD6DDB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U06644 Genomic DNA. Translation: AAB40004.1.
PIRiS53354.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U06644 Genomic DNA. Translation: AAB40004.1 .
PIRi S53354.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2LVV NMR - A 1-218 [» ]
ProteinModelPortali Q26680.
SMRi Q26680. Positions 22-208.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi NOG43316.

Family and domain databases

Gene3Di 1.10.238.10. 2 hits.
InterProi IPR003299. Calflagin-bd.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view ]
Pfami PF13405. EF-hand_6. 1 hit.
PF13499. EF-hand_7. 1 hit.
[Graphical view ]
PRINTSi PR01362. CALFLAGIN.
SMARTi SM00054. EFh. 3 hits.
[Graphical view ]
PROSITEi PS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The gene family of EF-hand calcium-binding proteins from the flagellum of Trypanosoma brucei."
    Wu Y., Deford J., Benjamin R., Lee M.G.-S., Ruben L.
    Biochem. J. 304:833-841(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 427.

Entry informationi

Entry nameiFCA2_TRYBB
AccessioniPrimary (citable) accession number: Q26680
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: October 29, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3