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Q26680

- FCA2_TRYBB

UniProt

Q26680 - FCA2_TRYBB

Protein

Flagellar calcium-binding protein TB-24

Gene
N/A
Organism
Trypanosoma brucei brucei
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    May contribute to the rapid motility of the trypanosomes, playing a role either in flagellar structure or in calcium metabolism. Could alternate between a GDP-bound inactive form to a calcium/GTP-bound active form.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi61 – 72121PROSITE-ProRule annotationAdd
    BLAST
    Calcium bindingi143 – 154122PROSITE-ProRule annotationAdd
    BLAST
    Calcium bindingi180 – 191123PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Flagellar calcium-binding protein TB-24
    Alternative name(s):
    24 kDa calcimedin
    24 kDa calflagin
    OrganismiTrypanosoma brucei brucei
    Taxonomic identifieri5702 [NCBI]
    Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosoma

    Subcellular locationi

    GO - Cellular componenti

    1. cilium Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell projection, Cilium, Flagellum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 218218Flagellar calcium-binding protein TB-24PRO_0000073737Add
    BLAST

    Structurei

    Secondary structure

    1
    218
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi20 – 223
    Helixi27 – 4014
    Helixi47 – 6014
    Helixi61 – 633
    Helixi71 – 799
    Turni84 – 863
    Beta strandi87 – 893
    Helixi91 – 10818
    Helixi119 – 14224
    Helixi152 – 16514
    Helixi173 – 1797
    Helixi189 – 20416
    Beta strandi209 – 2113

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2LVVNMR-A1-218[»]
    ProteinModelPortaliQ26680.
    SMRiQ26680. Positions 22-208.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini48 – 8336EF-hand 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini84 – 11936EF-hand 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini130 – 16536EF-hand 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini167 – 20236EF-hand 4PROSITE-ProRule annotationAdd
    BLAST

    Domaini

    This protein has four EF-hand domains, three of which may be functional calcium-binding sites.

    Sequence similaritiesi

    Belongs to the calflagin family.Curated
    Contains 4 EF-hand domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG43316.

    Family and domain databases

    Gene3Di1.10.238.10. 2 hits.
    InterProiIPR003299. Calflagin-bd.
    IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    [Graphical view]
    PfamiPF13405. EF-hand_6. 1 hit.
    PF13499. EF-hand_7. 1 hit.
    [Graphical view]
    PRINTSiPR01362. CALFLAGIN.
    SMARTiSM00054. EFh. 3 hits.
    [Graphical view]
    PROSITEiPS00018. EF_HAND_1. 2 hits.
    PS50222. EF_HAND_2. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q26680-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGCSASKDTT NSKDGAASKG GKDGKTTADR KVAWERIRCA IPRDKDAESK    50
    SRRIELFKQF DTNGTGKLGF REVLDGCYGI LKLDEFTTHL PDIVQRAFDK 100
    AKDLGNKVKG VGEEDLVEFL EFRLMLCYIY DIFELTVMFD TMDKDGSLLL 150
    ELQEFKEALP KLKEWGVDIT DATTVFNEID TNGSGVVTFD EFSCWAVTKK 200
    LQVCGDPDGE ENGANEGN 218
    Length:218
    Mass (Da):24,252
    Last modified:November 1, 1997 - v1
    Checksum:i041152AC2BDD6DDB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U06644 Genomic DNA. Translation: AAB40004.1.
    PIRiS53354.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U06644 Genomic DNA. Translation: AAB40004.1 .
    PIRi S53354.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2LVV NMR - A 1-218 [» ]
    ProteinModelPortali Q26680.
    SMRi Q26680. Positions 22-208.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    eggNOGi NOG43316.

    Family and domain databases

    Gene3Di 1.10.238.10. 2 hits.
    InterProi IPR003299. Calflagin-bd.
    IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    [Graphical view ]
    Pfami PF13405. EF-hand_6. 1 hit.
    PF13499. EF-hand_7. 1 hit.
    [Graphical view ]
    PRINTSi PR01362. CALFLAGIN.
    SMARTi SM00054. EFh. 3 hits.
    [Graphical view ]
    PROSITEi PS00018. EF_HAND_1. 2 hits.
    PS50222. EF_HAND_2. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The gene family of EF-hand calcium-binding proteins from the flagellum of Trypanosoma brucei."
      Wu Y., Deford J., Benjamin R., Lee M.G.-S., Ruben L.
      Biochem. J. 304:833-841(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 427.

    Entry informationi

    Entry nameiFCA2_TRYBB
    AccessioniPrimary (citable) accession number: Q26680
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    3D-structure

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3