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Protein

Cell division control protein 2 homolog

Gene

CRK2

Organism
Theileria annulata
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis. Component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Enzyme regulationi

Phosphorylation at Thr-14 or Tyr-15 inactivates the enzyme, while phosphorylation at Thr-158 activates it.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei32ATPPROSITE-ProRule annotation1
Active sitei125Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 18ATPPROSITE-ProRule annotation9

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division control protein 2 homolog (EC:2.7.11.22, EC:2.7.11.23)
Gene namesi
Name:CRK2
ORF Names:TA06730
OrganismiTheileria annulata
Taxonomic identifieri5874 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaPiroplasmidaTheileriidaeTheileria
Proteomesi
  • UP000001950 Componenti: Chromosome 1 part 1

Organism-specific databases

EuPathDBiPiroplasmaDB:TA06730

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002326731 – 298Cell division control protein 2 homologAdd BLAST298

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei14PhosphothreonineBy similarity1
Modified residuei15PhosphotyrosineBy similarity1
Modified residuei158Phosphothreonine; by CAKBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ26671

Interactioni

Subunit structurei

Forms a stable but non-covalent complex with a regulatory subunit and with a cyclin.By similarity

Protein-protein interaction databases

STRINGi353154.XP_954049.1

Structurei

3D structure databases

ProteinModelPortaliQ26671
SMRiQ26671
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 284Protein kinasePROSITE-ProRule annotationAdd BLAST281

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0594 Eukaryota
ENOG410XPP3 LUCA
HOGENOMiHOG000233024
InParanoidiQ26671
KOiK04563
OMAiEMMLVYD

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

Q26671-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRYHKMEKI GEGTYGVVYK AQNNHGEICA LKKIRVEEED EGIPSTAIRE
60 70 80 90 100
ISLLKELHHP NIVWLRDVIH SEKCLTLVFE YLDQDLKKLL DACDGGLEPT
110 120 130 140 150
TAKSFLYQIL RGISYCHDHR ILHRDLKPQN LLINREGVLK LADFGLARAF
160 170 180 190 200
AIPVRSYTHE VVTLWYRAPD VLMGSKKYST AVDIWSVGCI FAEMINGVPL
210 220 230 240 250
FPGISEQDQL KRIFKILGTP NVDSWPQVVN LPAYNPDFCY YEKQAWSSIV
260 270 280 290
PKLNESGIDL ISRMLQLDPV QRISAKEALK HDYFKDLHRP SEFLNGVH
Length:298
Mass (Da):34,231
Last modified:November 1, 1996 - v1
Checksum:iA4F8526448B4F727
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X98768 mRNA Translation: CAA67306.1
CR940347 Genomic DNA Translation: CAI73372.1
RefSeqiXP_954049.1, XM_948956.1

Genome annotation databases

EnsemblProtistsiCAI73372; CAI73372; TA06730
GeneIDi3863999
KEGGitan:TA06730

Similar proteinsi

Entry informationi

Entry nameiCDC2H_THEAN
AccessioniPrimary (citable) accession number: Q26671
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health