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Protein

Sperm receptor for egg jelly

Gene

REJ

Organism
Strongylocentrotus purpuratus (Purple sea urchin)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for the egg jelly ligands inducing the acrosome reaction. Could be a regulator of sperm ion channels.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Ligandi

Lectin

Protein family/group databases

MEROPSiP02.040.

Names & Taxonomyi

Protein namesi
Recommended name:
Sperm receptor for egg jelly
Short name:
suREJ
Gene namesi
Name:REJ
OrganismiStrongylocentrotus purpuratus (Purple sea urchin)
Taxonomic identifieri7668 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEchinodermataEleutherozoaEchinozoaEchinoideaEuechinoideaEchinaceaEchinoidaStrongylocentrotidaeStrongylocentrotus
Proteomesi
  • UP000007110 Componenti: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 1414ExtracellularSequence analysisAdd BLAST1388
Transmembranei1415 – 1435HelicalSequence analysisAdd BLAST21
Topological domaini1436 – 1450CytoplasmicSequence analysisAdd BLAST15

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000002430127 – 1450Sperm receptor for egg jellyAdd BLAST1424

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi31 ↔ 42By similarity
Disulfide bondi36 ↔ 51By similarity
Glycosylationi48N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi53 ↔ 62By similarity
Glycosylationi90N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi98 ↔ 189By similarity
Disulfide bondi165 ↔ 181By similarity
Glycosylationi175N-linked (GlcNAc...)Sequence analysis1
Glycosylationi184N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi201 ↔ 214By similarity
Disulfide bondi231 ↔ 323By similarity
Glycosylationi273N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi297 ↔ 315By similarity
Glycosylationi379N-linked (GlcNAc...)Sequence analysis1
Glycosylationi390N-linked (GlcNAc...)Sequence analysis1
Glycosylationi455N-linked (GlcNAc...)Sequence analysis1
Glycosylationi461N-linked (GlcNAc...)Sequence analysis1
Glycosylationi622N-linked (GlcNAc...)Sequence analysis1
Glycosylationi661N-linked (GlcNAc...)Sequence analysis1
Glycosylationi677N-linked (GlcNAc...)Sequence analysis1
Glycosylationi685N-linked (GlcNAc...)Sequence analysis1
Glycosylationi753N-linked (GlcNAc...)Sequence analysis1
Glycosylationi842N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1311N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1344N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Developmental stagei

Expressed at the earliest stage of spermiogenesis.

Interactioni

Protein-protein interaction databases

STRINGi7668.SPU_023767tr.

Structurei

3D structure databases

ProteinModelPortaliQ26627.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 63EGF-likePROSITE-ProRule annotationAdd BLAST37
Domaini77 – 190C-type lectin 1PROSITE-ProRule annotationAdd BLAST114
Domaini210 – 324C-type lectin 2PROSITE-ProRule annotationAdd BLAST115
Domaini468 – 1187REJPROSITE-ProRule annotationAdd BLAST720
Domaini1353 – 1403GPSPROSITE-ProRule annotationAdd BLAST51

Sequence similaritiesi

Belongs to the polycystin family.Curated
Contains 2 C-type lectin domains.PROSITE-ProRule annotation
Contains 1 EGF-like domain.PROSITE-ProRule annotation
Contains 1 GPS domain.PROSITE-ProRule annotation
Contains 1 REJ domain.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3599. Eukaryota.
KOG4297. Eukaryota.
ENOG410XTGE. LUCA.
InParanoidiQ26627.
OrthoDBiEOG091G00CF.

Family and domain databases

Gene3Di3.10.100.10. 2 hits.
InterProiIPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR016187. CTDL_fold.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR000203. GPS.
IPR002859. PKD/REJ-like.
IPR014010. REJ_dom.
[Graphical view]
PfamiPF00008. EGF. 1 hit.
PF01825. GPS. 1 hit.
PF00059. Lectin_C. 2 hits.
PF02010. REJ. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 2 hits.
SM00181. EGF. 1 hit.
SM00179. EGF_CA. 1 hit.
SM00303. GPS. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 2 hits.
PROSITEiPS00010. ASX_HYDROXYL. 1 hit.
PS50041. C_TYPE_LECTIN_2. 2 hits.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS50221. GPS. 1 hit.
PS51111. REJ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q26627-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVFVILILF NAILNFKTVG PAAVSSKTVD CASAPCMNGG TCADGFNNFT
60 70 80 90 100
CFCEEGFTGS MCETEYGCFR PWFYGPAFGY CYLWERVDYN WTQARESCID
110 120 130 140 150
QGRGAELASI HSAEENAFVY AQIRRYAWIG LSDQVTEGVF DYADGTPVDY
160 170 180 190 200
LSFPDKNKQS ETRDCVYVKH LRVDNWSLLD CRANKTSICK STTTFSATDG
210 220 230 240 250
CATGWVHNPA TGYCYFYEER GGMWSKGREF CLDAGADLAS IHSAEENAFI
260 270 280 290 300
FDMLTEFVWL GLNDLETEGV YTNFSDGTPA DFDNFPADNY QNEDHDCVSI
310 320 330 340 350
RHLEKTDRYW FFLGCDDTVT SICKRPHEVV ATQAPPYLFT TTDVPATTTT
360 370 380 390 400
IPTTTTTISA TTRTIDAMIL IELLLFPNNV SSIDNIFRVN NTILVTASVL
410 420 430 440 450
GSFQALSSQI LWSITNHLSG DSVQYTVYSE DAVLVRFTTV SIFTIKATAV
460 470 480 490 500
GNSHNLTATA NATVKHVCIS SLTTSVKEHC DAPHPAVYLR AFDIHISTHM
510 520 530 540 550
ELNGKCIDPM TPDFKWRIFT STEADDVVTA FEKITHTRQV MIPRGTLPYG
560 570 580 590 600
IYSLNLNAKT RLKTSGEVTG EKEIISWLEI QPPPLVAVIK GGASRSHGVS
610 620 630 640 650
SNLIVDGSNS YDPDVPPGSS SNVTFLWYCV VVDPDVMYSS LDEAIQNTDN
660 670 680 690 700
ACFEDEGIMM NSTSSMIEVI ANKLNANVTM NFWLNISKEG QISGLTQQRI
710 720 730 740 750
HLTLGLLPEI EISCISNCNM YIFTAERLVL HASCTNCDSE NEDVSFRWSL
760 770 780 790 800
ESNHTSVIGD LSSQTTTGLD QPYLVLKPLT FDSISEMGSI ILRVTGSQSD
810 820 830 840 850
SDGYAEFSVD LPHNAPPALG SCVVTPDEGY ALQTDFTVTC SNFTDVDEPL
860 870 880 890 900
TYQIILFSHV DVVDWMFVGR GEGFQLYEGS APIKDGLYLP VGVGTDDHDI
910 920 930 940 950
LLQVNVRDCN MASTSVYISA TVHPPTLDAV GMNLVQELLD MALLVETNVN
960 970 980 990 1000
ALLAVGDPGQ AAQLISALGS ILNSIGDEDD SEEGRETRSE IRSFLVDCVA
1010 1020 1030 1040 1050
AIPVESMTSL KQSSAALAVV THNKQEISTH VQMLAASTLS EMTSFVKSKS
1060 1070 1080 1090 1100
GSYTQAQENI ESAGTILVEG LSNILSAAKE TERLLSDDTS QEREDHKNLI
1110 1120 1130 1140 1150
EVAVSTINDI QDAIVAGKIP SEAATIITSP ALSIAVGSIS RDELAEATFG
1160 1170 1180 1190 1200
GPEDLGSFRM PSQDVLNQAM EHALGTTVSM KMSAMKWNPF SWPGAGGESI
1210 1220 1230 1240 1250
KSSIVGIQLE ADQMLEFHDL TADIDVYLPM RETLSADPVS VHITKTSSDS
1260 1270 1280 1290 1300
VLIDHSSLPV DGALHLTVIA ENEPMVALSI CTARISITES SCVGTDTPLG
1310 1320 1330 1340 1350
VSNEDPDTDA NFTWTVPLVD LKAADGIMIR LYDSEDQPGY ENDNITLSVF
1360 1370 1380 1390 1400
MHTLQCNFWN EDQQEWDSTG CKVGPLSKPS TTHCLCNHLT GFFGSSILVP
1410 1420 1430 1440 1450
PNHAQPVIGG HKLTGVDFLI CVLIGYGIYC VALVIRVVGC SFAIRVHKVL
Length:1,450
Mass (Da):158,165
Last modified:November 1, 1996 - v1
Checksum:i66C322FB26F918F5
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti440V → A.1 Publication1
Natural varianti593A → P.1 Publication1
Natural varianti1204I → M.1 Publication1
Natural varianti1371C → S.1 Publication1
Natural varianti1390T → A.1 Publication1
Natural varianti1443A → V.1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U40832 mRNA. Translation: AAB08448.1.
PIRiT30273.
RefSeqiNP_999773.1. NM_214608.1.
UniGeneiSpu.212.

Genome annotation databases

EnsemblMetazoaiSPU_023767-tr; SPU_023767-tr; SPU_023767.
GeneIDi373460.
KEGGispu:373460.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U40832 mRNA. Translation: AAB08448.1.
PIRiT30273.
RefSeqiNP_999773.1. NM_214608.1.
UniGeneiSpu.212.

3D structure databases

ProteinModelPortaliQ26627.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7668.SPU_023767tr.

Protein family/group databases

MEROPSiP02.040.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiSPU_023767-tr; SPU_023767-tr; SPU_023767.
GeneIDi373460.
KEGGispu:373460.

Organism-specific databases

CTDi373460.

Phylogenomic databases

eggNOGiKOG3599. Eukaryota.
KOG4297. Eukaryota.
ENOG410XTGE. LUCA.
InParanoidiQ26627.
OrthoDBiEOG091G00CF.

Family and domain databases

Gene3Di3.10.100.10. 2 hits.
InterProiIPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR016187. CTDL_fold.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR000203. GPS.
IPR002859. PKD/REJ-like.
IPR014010. REJ_dom.
[Graphical view]
PfamiPF00008. EGF. 1 hit.
PF01825. GPS. 1 hit.
PF00059. Lectin_C. 2 hits.
PF02010. REJ. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 2 hits.
SM00181. EGF. 1 hit.
SM00179. EGF_CA. 1 hit.
SM00303. GPS. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 2 hits.
PROSITEiPS00010. ASX_HYDROXYL. 1 hit.
PS50041. C_TYPE_LECTIN_2. 2 hits.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS50221. GPS. 1 hit.
PS51111. REJ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSUREJ_STRPU
AccessioniPrimary (citable) accession number: Q26627
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.