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Q26627

- SUREJ_STRPU

UniProt

Q26627 - SUREJ_STRPU

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Protein
Sperm receptor for egg jelly
Gene
REJ
Organism
Strongylocentrotus purpuratus (Purple sea urchin)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Receptor for the egg jelly ligands inducing the acrosome reaction. Could be a regulator of sperm ion channels.

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. neuropeptide signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
Sperm receptor for egg jelly
Short name:
suREJ
Gene namesi
Name:REJ
OrganismiStrongylocentrotus purpuratus (Purple sea urchin)
Taxonomic identifieri7668 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEchinodermataEleutherozoaEchinozoaEchinoideaEuechinoideaEchinaceaEchinoidaStrongylocentrotidaeStrongylocentrotus
ProteomesiUP000007110: Unplaced

Subcellular locationi

Cell membrane; Single-pass type I membrane protein
Note: Present on the surface of the sperm flagellum and also on a thin belt of membrane directly over the acrosomal granule at the anterior apex of the sperm head.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini27 – 14141388Extracellular Reviewed prediction
Add
BLAST
Transmembranei1415 – 143521Helical; Reviewed prediction
Add
BLAST
Topological domaini1436 – 145015Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626 Reviewed prediction
Add
BLAST
Chaini27 – 14501424Sperm receptor for egg jelly
PRO_0000024301Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi31 ↔ 42 By similarity
Disulfide bondi36 ↔ 51 By similarity
Glycosylationi48 – 481N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi53 ↔ 62 By similarity
Glycosylationi90 – 901N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi98 ↔ 189 By similarity
Disulfide bondi165 ↔ 181 By similarity
Glycosylationi175 – 1751N-linked (GlcNAc...) Reviewed prediction
Glycosylationi184 – 1841N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi201 ↔ 214 By similarity
Disulfide bondi231 ↔ 323 By similarity
Glycosylationi273 – 2731N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi297 ↔ 315 By similarity
Glycosylationi379 – 3791N-linked (GlcNAc...) Reviewed prediction
Glycosylationi390 – 3901N-linked (GlcNAc...) Reviewed prediction
Glycosylationi455 – 4551N-linked (GlcNAc...) Reviewed prediction
Glycosylationi461 – 4611N-linked (GlcNAc...) Reviewed prediction
Glycosylationi622 – 6221N-linked (GlcNAc...) Reviewed prediction
Glycosylationi661 – 6611N-linked (GlcNAc...) Reviewed prediction
Glycosylationi677 – 6771N-linked (GlcNAc...) Reviewed prediction
Glycosylationi685 – 6851N-linked (GlcNAc...) Reviewed prediction
Glycosylationi753 – 7531N-linked (GlcNAc...) Reviewed prediction
Glycosylationi842 – 8421N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1311 – 13111N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1344 – 13441N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Developmental stagei

Expressed at the earliest stage of spermiogenesis.

Interactioni

Protein-protein interaction databases

STRINGi7668.Q26627.

Structurei

3D structure databases

ProteinModelPortaliQ26627.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 6337EGF-like
Add
BLAST
Domaini77 – 190114C-type lectin 1
Add
BLAST
Domaini210 – 324115C-type lectin 2
Add
BLAST
Domaini468 – 1187720REJ
Add
BLAST
Domaini1353 – 140351GPS
Add
BLAST

Sequence similaritiesi

Belongs to the polycystin family.
Contains 1 EGF-like domain.
Contains 1 GPS domain.
Contains 1 REJ domain.

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG294369.
InParanoidiQ26627.

Family and domain databases

Gene3Di3.10.100.10. 2 hits.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR000203. GPS.
IPR002859. PKD/REJ-like.
IPR014010. REJ-like.
[Graphical view]
PfamiPF00008. EGF. 1 hit.
PF01825. GPS. 1 hit.
PF00059. Lectin_C. 2 hits.
PF02010. REJ. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 2 hits.
SM00181. EGF. 1 hit.
SM00303. GPS. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 2 hits.
PROSITEiPS00010. ASX_HYDROXYL. 1 hit.
PS50041. C_TYPE_LECTIN_2. 2 hits.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS50221. GPS. 1 hit.
PS51111. REJ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q26627-1 [UniParc]FASTAAdd to Basket

« Hide

MSVFVILILF NAILNFKTVG PAAVSSKTVD CASAPCMNGG TCADGFNNFT     50
CFCEEGFTGS MCETEYGCFR PWFYGPAFGY CYLWERVDYN WTQARESCID 100
QGRGAELASI HSAEENAFVY AQIRRYAWIG LSDQVTEGVF DYADGTPVDY 150
LSFPDKNKQS ETRDCVYVKH LRVDNWSLLD CRANKTSICK STTTFSATDG 200
CATGWVHNPA TGYCYFYEER GGMWSKGREF CLDAGADLAS IHSAEENAFI 250
FDMLTEFVWL GLNDLETEGV YTNFSDGTPA DFDNFPADNY QNEDHDCVSI 300
RHLEKTDRYW FFLGCDDTVT SICKRPHEVV ATQAPPYLFT TTDVPATTTT 350
IPTTTTTISA TTRTIDAMIL IELLLFPNNV SSIDNIFRVN NTILVTASVL 400
GSFQALSSQI LWSITNHLSG DSVQYTVYSE DAVLVRFTTV SIFTIKATAV 450
GNSHNLTATA NATVKHVCIS SLTTSVKEHC DAPHPAVYLR AFDIHISTHM 500
ELNGKCIDPM TPDFKWRIFT STEADDVVTA FEKITHTRQV MIPRGTLPYG 550
IYSLNLNAKT RLKTSGEVTG EKEIISWLEI QPPPLVAVIK GGASRSHGVS 600
SNLIVDGSNS YDPDVPPGSS SNVTFLWYCV VVDPDVMYSS LDEAIQNTDN 650
ACFEDEGIMM NSTSSMIEVI ANKLNANVTM NFWLNISKEG QISGLTQQRI 700
HLTLGLLPEI EISCISNCNM YIFTAERLVL HASCTNCDSE NEDVSFRWSL 750
ESNHTSVIGD LSSQTTTGLD QPYLVLKPLT FDSISEMGSI ILRVTGSQSD 800
SDGYAEFSVD LPHNAPPALG SCVVTPDEGY ALQTDFTVTC SNFTDVDEPL 850
TYQIILFSHV DVVDWMFVGR GEGFQLYEGS APIKDGLYLP VGVGTDDHDI 900
LLQVNVRDCN MASTSVYISA TVHPPTLDAV GMNLVQELLD MALLVETNVN 950
ALLAVGDPGQ AAQLISALGS ILNSIGDEDD SEEGRETRSE IRSFLVDCVA 1000
AIPVESMTSL KQSSAALAVV THNKQEISTH VQMLAASTLS EMTSFVKSKS 1050
GSYTQAQENI ESAGTILVEG LSNILSAAKE TERLLSDDTS QEREDHKNLI 1100
EVAVSTINDI QDAIVAGKIP SEAATIITSP ALSIAVGSIS RDELAEATFG 1150
GPEDLGSFRM PSQDVLNQAM EHALGTTVSM KMSAMKWNPF SWPGAGGESI 1200
KSSIVGIQLE ADQMLEFHDL TADIDVYLPM RETLSADPVS VHITKTSSDS 1250
VLIDHSSLPV DGALHLTVIA ENEPMVALSI CTARISITES SCVGTDTPLG 1300
VSNEDPDTDA NFTWTVPLVD LKAADGIMIR LYDSEDQPGY ENDNITLSVF 1350
MHTLQCNFWN EDQQEWDSTG CKVGPLSKPS TTHCLCNHLT GFFGSSILVP 1400
PNHAQPVIGG HKLTGVDFLI CVLIGYGIYC VALVIRVVGC SFAIRVHKVL 1450
Length:1,450
Mass (Da):158,165
Last modified:November 1, 1996 - v1
Checksum:i66C322FB26F918F5
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti440 – 4401V → A.1 Publication
Natural varianti593 – 5931A → P.1 Publication
Natural varianti1204 – 12041I → M.1 Publication
Natural varianti1371 – 13711C → S.1 Publication
Natural varianti1390 – 13901T → A.1 Publication
Natural varianti1443 – 14431A → V.1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U40832 mRNA. Translation: AAB08448.1.
PIRiT30273.
RefSeqiNP_999773.1. NM_214608.1.
UniGeneiSpu.212.

Genome annotation databases

EnsemblMetazoaiSPU_023767-tr; SPU_023767-tr; SPU_023767.
GeneIDi373460.
KEGGispu:373460.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U40832 mRNA. Translation: AAB08448.1 .
PIRi T30273.
RefSeqi NP_999773.1. NM_214608.1.
UniGenei Spu.212.

3D structure databases

ProteinModelPortali Q26627.
ModBasei Search...

Protein-protein interaction databases

STRINGi 7668.Q26627.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai SPU_023767-tr ; SPU_023767-tr ; SPU_023767 .
GeneIDi 373460.
KEGGi spu:373460.

Organism-specific databases

CTDi 373460.

Phylogenomic databases

eggNOGi NOG294369.
InParanoidi Q26627.

Family and domain databases

Gene3Di 3.10.100.10. 2 hits.
InterProi IPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR000203. GPS.
IPR002859. PKD/REJ-like.
IPR014010. REJ-like.
[Graphical view ]
Pfami PF00008. EGF. 1 hit.
PF01825. GPS. 1 hit.
PF00059. Lectin_C. 2 hits.
PF02010. REJ. 1 hit.
[Graphical view ]
SMARTi SM00034. CLECT. 2 hits.
SM00181. EGF. 1 hit.
SM00303. GPS. 1 hit.
[Graphical view ]
SUPFAMi SSF56436. SSF56436. 2 hits.
PROSITEi PS00010. ASX_HYDROXYL. 1 hit.
PS50041. C_TYPE_LECTIN_2. 2 hits.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS50221. GPS. 1 hit.
PS51111. REJ. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The sea urchin sperm receptor for egg jelly is a modular protein with extensive homology to the human polycystic kidney disease protein, PKD1."
    Moy G.W., Mendoza L.M., Schulz J.R., Swanson W.J., Glabe C.G., Vacquier V.D.
    J. Cell Biol. 133:809-817(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE, VARIANTS ALA-440; PRO-593; MET-1204; SER-1371; ALA-1390 AND VAL-1443.
    Tissue: Testis.

Entry informationi

Entry nameiSUREJ_STRPU
AccessioniPrimary (citable) accession number: Q26627
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: November 1, 1996
Last modified: March 19, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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