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Q26627

- SUREJ_STRPU

UniProt

Q26627 - SUREJ_STRPU

Protein

Sperm receptor for egg jelly

Gene

REJ

Organism
Strongylocentrotus purpuratus (Purple sea urchin)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Receptor for the egg jelly ligands inducing the acrosome reaction. Could be a regulator of sperm ion channels.

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro

    GO - Biological processi

    1. neuropeptide signaling pathway Source: InterPro

    Keywords - Molecular functioni

    Receptor

    Keywords - Ligandi

    Lectin

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sperm receptor for egg jelly
    Short name:
    suREJ
    Gene namesi
    Name:REJ
    OrganismiStrongylocentrotus purpuratus (Purple sea urchin)
    Taxonomic identifieri7668 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEchinodermataEleutherozoaEchinozoaEchinoideaEuechinoideaEchinaceaEchinoidaStrongylocentrotidaeStrongylocentrotus
    ProteomesiUP000007110: Unplaced

    Subcellular locationi

    Cell membrane; Single-pass type I membrane protein
    Note: Present on the surface of the sperm flagellum and also on a thin belt of membrane directly over the acrosomal granule at the anterior apex of the sperm head.

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2626Sequence AnalysisAdd
    BLAST
    Chaini27 – 14501424Sperm receptor for egg jellyPRO_0000024301Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi31 ↔ 42By similarity
    Disulfide bondi36 ↔ 51By similarity
    Glycosylationi48 – 481N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi53 ↔ 62By similarity
    Glycosylationi90 – 901N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi98 ↔ 189By similarity
    Disulfide bondi165 ↔ 181By similarity
    Glycosylationi175 – 1751N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi184 – 1841N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi201 ↔ 214By similarity
    Disulfide bondi231 ↔ 323By similarity
    Glycosylationi273 – 2731N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi297 ↔ 315By similarity
    Glycosylationi379 – 3791N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi390 – 3901N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi455 – 4551N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi461 – 4611N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi622 – 6221N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi661 – 6611N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi677 – 6771N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi685 – 6851N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi753 – 7531N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi842 – 8421N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1311 – 13111N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1344 – 13441N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Expressioni

    Developmental stagei

    Expressed at the earliest stage of spermiogenesis.

    Interactioni

    Protein-protein interaction databases

    STRINGi7668.Q26627.

    Structurei

    3D structure databases

    ProteinModelPortaliQ26627.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini27 – 14141388ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1436 – 145015CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1415 – 143521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini27 – 6337EGF-likePROSITE-ProRule annotationAdd
    BLAST
    Domaini77 – 190114C-type lectin 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini210 – 324115C-type lectin 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini468 – 1187720REJPROSITE-ProRule annotationAdd
    BLAST
    Domaini1353 – 140351GPSPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the polycystin family.Curated
    Contains 2 C-type lectin domains.PROSITE-ProRule annotation
    Contains 1 EGF-like domain.PROSITE-ProRule annotation
    Contains 1 GPS domain.PROSITE-ProRule annotation
    Contains 1 REJ domain.PROSITE-ProRule annotation

    Keywords - Domaini

    EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG294369.
    InParanoidiQ26627.

    Family and domain databases

    Gene3Di3.10.100.10. 2 hits.
    InterProiIPR001304. C-type_lectin.
    IPR016186. C-type_lectin-like.
    IPR016187. C-type_lectin_fold.
    IPR000742. EG-like_dom.
    IPR013032. EGF-like_CS.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR000203. GPS.
    IPR002859. PKD/REJ-like.
    IPR014010. REJ-like.
    [Graphical view]
    PfamiPF00008. EGF. 1 hit.
    PF01825. GPS. 1 hit.
    PF00059. Lectin_C. 2 hits.
    PF02010. REJ. 1 hit.
    [Graphical view]
    SMARTiSM00034. CLECT. 2 hits.
    SM00181. EGF. 1 hit.
    SM00303. GPS. 1 hit.
    [Graphical view]
    SUPFAMiSSF56436. SSF56436. 2 hits.
    PROSITEiPS00010. ASX_HYDROXYL. 1 hit.
    PS50041. C_TYPE_LECTIN_2. 2 hits.
    PS00022. EGF_1. 1 hit.
    PS01186. EGF_2. 1 hit.
    PS50026. EGF_3. 1 hit.
    PS50221. GPS. 1 hit.
    PS51111. REJ. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q26627-1 [UniParc]FASTAAdd to Basket

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    MSVFVILILF NAILNFKTVG PAAVSSKTVD CASAPCMNGG TCADGFNNFT     50
    CFCEEGFTGS MCETEYGCFR PWFYGPAFGY CYLWERVDYN WTQARESCID 100
    QGRGAELASI HSAEENAFVY AQIRRYAWIG LSDQVTEGVF DYADGTPVDY 150
    LSFPDKNKQS ETRDCVYVKH LRVDNWSLLD CRANKTSICK STTTFSATDG 200
    CATGWVHNPA TGYCYFYEER GGMWSKGREF CLDAGADLAS IHSAEENAFI 250
    FDMLTEFVWL GLNDLETEGV YTNFSDGTPA DFDNFPADNY QNEDHDCVSI 300
    RHLEKTDRYW FFLGCDDTVT SICKRPHEVV ATQAPPYLFT TTDVPATTTT 350
    IPTTTTTISA TTRTIDAMIL IELLLFPNNV SSIDNIFRVN NTILVTASVL 400
    GSFQALSSQI LWSITNHLSG DSVQYTVYSE DAVLVRFTTV SIFTIKATAV 450
    GNSHNLTATA NATVKHVCIS SLTTSVKEHC DAPHPAVYLR AFDIHISTHM 500
    ELNGKCIDPM TPDFKWRIFT STEADDVVTA FEKITHTRQV MIPRGTLPYG 550
    IYSLNLNAKT RLKTSGEVTG EKEIISWLEI QPPPLVAVIK GGASRSHGVS 600
    SNLIVDGSNS YDPDVPPGSS SNVTFLWYCV VVDPDVMYSS LDEAIQNTDN 650
    ACFEDEGIMM NSTSSMIEVI ANKLNANVTM NFWLNISKEG QISGLTQQRI 700
    HLTLGLLPEI EISCISNCNM YIFTAERLVL HASCTNCDSE NEDVSFRWSL 750
    ESNHTSVIGD LSSQTTTGLD QPYLVLKPLT FDSISEMGSI ILRVTGSQSD 800
    SDGYAEFSVD LPHNAPPALG SCVVTPDEGY ALQTDFTVTC SNFTDVDEPL 850
    TYQIILFSHV DVVDWMFVGR GEGFQLYEGS APIKDGLYLP VGVGTDDHDI 900
    LLQVNVRDCN MASTSVYISA TVHPPTLDAV GMNLVQELLD MALLVETNVN 950
    ALLAVGDPGQ AAQLISALGS ILNSIGDEDD SEEGRETRSE IRSFLVDCVA 1000
    AIPVESMTSL KQSSAALAVV THNKQEISTH VQMLAASTLS EMTSFVKSKS 1050
    GSYTQAQENI ESAGTILVEG LSNILSAAKE TERLLSDDTS QEREDHKNLI 1100
    EVAVSTINDI QDAIVAGKIP SEAATIITSP ALSIAVGSIS RDELAEATFG 1150
    GPEDLGSFRM PSQDVLNQAM EHALGTTVSM KMSAMKWNPF SWPGAGGESI 1200
    KSSIVGIQLE ADQMLEFHDL TADIDVYLPM RETLSADPVS VHITKTSSDS 1250
    VLIDHSSLPV DGALHLTVIA ENEPMVALSI CTARISITES SCVGTDTPLG 1300
    VSNEDPDTDA NFTWTVPLVD LKAADGIMIR LYDSEDQPGY ENDNITLSVF 1350
    MHTLQCNFWN EDQQEWDSTG CKVGPLSKPS TTHCLCNHLT GFFGSSILVP 1400
    PNHAQPVIGG HKLTGVDFLI CVLIGYGIYC VALVIRVVGC SFAIRVHKVL 1450
    Length:1,450
    Mass (Da):158,165
    Last modified:November 1, 1996 - v1
    Checksum:i66C322FB26F918F5
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti440 – 4401V → A.1 Publication
    Natural varianti593 – 5931A → P.1 Publication
    Natural varianti1204 – 12041I → M.1 Publication
    Natural varianti1371 – 13711C → S.1 Publication
    Natural varianti1390 – 13901T → A.1 Publication
    Natural varianti1443 – 14431A → V.1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U40832 mRNA. Translation: AAB08448.1.
    PIRiT30273.
    RefSeqiNP_999773.1. NM_214608.1.
    UniGeneiSpu.212.

    Genome annotation databases

    EnsemblMetazoaiSPU_023767-tr; SPU_023767-tr; SPU_023767.
    GeneIDi373460.
    KEGGispu:373460.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U40832 mRNA. Translation: AAB08448.1 .
    PIRi T30273.
    RefSeqi NP_999773.1. NM_214608.1.
    UniGenei Spu.212.

    3D structure databases

    ProteinModelPortali Q26627.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7668.Q26627.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai SPU_023767-tr ; SPU_023767-tr ; SPU_023767 .
    GeneIDi 373460.
    KEGGi spu:373460.

    Organism-specific databases

    CTDi 373460.

    Phylogenomic databases

    eggNOGi NOG294369.
    InParanoidi Q26627.

    Family and domain databases

    Gene3Di 3.10.100.10. 2 hits.
    InterProi IPR001304. C-type_lectin.
    IPR016186. C-type_lectin-like.
    IPR016187. C-type_lectin_fold.
    IPR000742. EG-like_dom.
    IPR013032. EGF-like_CS.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR000203. GPS.
    IPR002859. PKD/REJ-like.
    IPR014010. REJ-like.
    [Graphical view ]
    Pfami PF00008. EGF. 1 hit.
    PF01825. GPS. 1 hit.
    PF00059. Lectin_C. 2 hits.
    PF02010. REJ. 1 hit.
    [Graphical view ]
    SMARTi SM00034. CLECT. 2 hits.
    SM00181. EGF. 1 hit.
    SM00303. GPS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56436. SSF56436. 2 hits.
    PROSITEi PS00010. ASX_HYDROXYL. 1 hit.
    PS50041. C_TYPE_LECTIN_2. 2 hits.
    PS00022. EGF_1. 1 hit.
    PS01186. EGF_2. 1 hit.
    PS50026. EGF_3. 1 hit.
    PS50221. GPS. 1 hit.
    PS51111. REJ. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The sea urchin sperm receptor for egg jelly is a modular protein with extensive homology to the human polycystic kidney disease protein, PKD1."
      Moy G.W., Mendoza L.M., Schulz J.R., Swanson W.J., Glabe C.G., Vacquier V.D.
      J. Cell Biol. 133:809-817(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE, VARIANTS ALA-440; PRO-593; MET-1204; SER-1371; ALA-1390 AND VAL-1443.
      Tissue: Testis.

    Entry informationi

    Entry nameiSUREJ_STRPU
    AccessioniPrimary (citable) accession number: Q26627
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2002
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3