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Q26627 (SUREJ_STRPU) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sperm receptor for egg jelly

Short name=suREJ
Gene names
Name:REJ
OrganismStrongylocentrotus purpuratus (Purple sea urchin) [Reference proteome]
Taxonomic identifier7668 [NCBI]
Taxonomic lineageEukaryotaMetazoaEchinodermataEleutherozoaEchinozoaEchinoideaEuechinoideaEchinaceaEchinoidaStrongylocentrotidaeStrongylocentrotus

Protein attributes

Sequence length1450 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Receptor for the egg jelly ligands inducing the acrosome reaction. Could be a regulator of sperm ion channels.

Subcellular location

Cell membrane; Single-pass type I membrane protein. Note: Present on the surface of the sperm flagellum and also on a thin belt of membrane directly over the acrosomal granule at the anterior apex of the sperm head.

Developmental stage

Expressed at the earliest stage of spermiogenesis.

Sequence similarities

Belongs to the polycystin family.

Contains 2 C-type lectin domains.

Contains 1 EGF-like domain.

Contains 1 GPS domain.

Contains 1 REJ domain.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   Coding sequence diversityPolymorphism
   DomainEGF-like domain
Repeat
Signal
Transmembrane
Transmembrane helix
   LigandLectin
   Molecular functionReceptor
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processneuropeptide signaling pathway

Inferred from electronic annotation. Source: InterPro

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncarbohydrate binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626 Potential
Chain27 – 14501424Sperm receptor for egg jelly
PRO_0000024301

Regions

Topological domain27 – 14141388Extracellular Potential
Transmembrane1415 – 143521Helical; Potential
Topological domain1436 – 145015Cytoplasmic Potential
Domain27 – 6337EGF-like
Domain77 – 190114C-type lectin 1
Domain210 – 324115C-type lectin 2
Domain468 – 1187720REJ
Domain1353 – 140351GPS

Amino acid modifications

Glycosylation481N-linked (GlcNAc...) Potential
Glycosylation901N-linked (GlcNAc...) Potential
Glycosylation1751N-linked (GlcNAc...) Potential
Glycosylation1841N-linked (GlcNAc...) Potential
Glycosylation2731N-linked (GlcNAc...) Potential
Glycosylation3791N-linked (GlcNAc...) Potential
Glycosylation3901N-linked (GlcNAc...) Potential
Glycosylation4551N-linked (GlcNAc...) Potential
Glycosylation4611N-linked (GlcNAc...) Potential
Glycosylation6221N-linked (GlcNAc...) Potential
Glycosylation6611N-linked (GlcNAc...) Potential
Glycosylation6771N-linked (GlcNAc...) Potential
Glycosylation6851N-linked (GlcNAc...) Potential
Glycosylation7531N-linked (GlcNAc...) Potential
Glycosylation8421N-linked (GlcNAc...) Potential
Glycosylation13111N-linked (GlcNAc...) Potential
Glycosylation13441N-linked (GlcNAc...) Potential
Disulfide bond31 ↔ 42 By similarity
Disulfide bond36 ↔ 51 By similarity
Disulfide bond53 ↔ 62 By similarity
Disulfide bond98 ↔ 189 By similarity
Disulfide bond165 ↔ 181 By similarity
Disulfide bond201 ↔ 214 By similarity
Disulfide bond231 ↔ 323 By similarity
Disulfide bond297 ↔ 315 By similarity

Natural variations

Natural variant4401V → A. Ref.1
Natural variant5931A → P. Ref.1
Natural variant12041I → M. Ref.1
Natural variant13711C → S. Ref.1
Natural variant13901T → A. Ref.1
Natural variant14431A → V. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q26627 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 66C322FB26F918F5

FASTA1,450158,165
        10         20         30         40         50         60 
MSVFVILILF NAILNFKTVG PAAVSSKTVD CASAPCMNGG TCADGFNNFT CFCEEGFTGS 

        70         80         90        100        110        120 
MCETEYGCFR PWFYGPAFGY CYLWERVDYN WTQARESCID QGRGAELASI HSAEENAFVY 

       130        140        150        160        170        180 
AQIRRYAWIG LSDQVTEGVF DYADGTPVDY LSFPDKNKQS ETRDCVYVKH LRVDNWSLLD 

       190        200        210        220        230        240 
CRANKTSICK STTTFSATDG CATGWVHNPA TGYCYFYEER GGMWSKGREF CLDAGADLAS 

       250        260        270        280        290        300 
IHSAEENAFI FDMLTEFVWL GLNDLETEGV YTNFSDGTPA DFDNFPADNY QNEDHDCVSI 

       310        320        330        340        350        360 
RHLEKTDRYW FFLGCDDTVT SICKRPHEVV ATQAPPYLFT TTDVPATTTT IPTTTTTISA 

       370        380        390        400        410        420 
TTRTIDAMIL IELLLFPNNV SSIDNIFRVN NTILVTASVL GSFQALSSQI LWSITNHLSG 

       430        440        450        460        470        480 
DSVQYTVYSE DAVLVRFTTV SIFTIKATAV GNSHNLTATA NATVKHVCIS SLTTSVKEHC 

       490        500        510        520        530        540 
DAPHPAVYLR AFDIHISTHM ELNGKCIDPM TPDFKWRIFT STEADDVVTA FEKITHTRQV 

       550        560        570        580        590        600 
MIPRGTLPYG IYSLNLNAKT RLKTSGEVTG EKEIISWLEI QPPPLVAVIK GGASRSHGVS 

       610        620        630        640        650        660 
SNLIVDGSNS YDPDVPPGSS SNVTFLWYCV VVDPDVMYSS LDEAIQNTDN ACFEDEGIMM 

       670        680        690        700        710        720 
NSTSSMIEVI ANKLNANVTM NFWLNISKEG QISGLTQQRI HLTLGLLPEI EISCISNCNM 

       730        740        750        760        770        780 
YIFTAERLVL HASCTNCDSE NEDVSFRWSL ESNHTSVIGD LSSQTTTGLD QPYLVLKPLT 

       790        800        810        820        830        840 
FDSISEMGSI ILRVTGSQSD SDGYAEFSVD LPHNAPPALG SCVVTPDEGY ALQTDFTVTC 

       850        860        870        880        890        900 
SNFTDVDEPL TYQIILFSHV DVVDWMFVGR GEGFQLYEGS APIKDGLYLP VGVGTDDHDI 

       910        920        930        940        950        960 
LLQVNVRDCN MASTSVYISA TVHPPTLDAV GMNLVQELLD MALLVETNVN ALLAVGDPGQ 

       970        980        990       1000       1010       1020 
AAQLISALGS ILNSIGDEDD SEEGRETRSE IRSFLVDCVA AIPVESMTSL KQSSAALAVV 

      1030       1040       1050       1060       1070       1080 
THNKQEISTH VQMLAASTLS EMTSFVKSKS GSYTQAQENI ESAGTILVEG LSNILSAAKE 

      1090       1100       1110       1120       1130       1140 
TERLLSDDTS QEREDHKNLI EVAVSTINDI QDAIVAGKIP SEAATIITSP ALSIAVGSIS 

      1150       1160       1170       1180       1190       1200 
RDELAEATFG GPEDLGSFRM PSQDVLNQAM EHALGTTVSM KMSAMKWNPF SWPGAGGESI 

      1210       1220       1230       1240       1250       1260 
KSSIVGIQLE ADQMLEFHDL TADIDVYLPM RETLSADPVS VHITKTSSDS VLIDHSSLPV 

      1270       1280       1290       1300       1310       1320 
DGALHLTVIA ENEPMVALSI CTARISITES SCVGTDTPLG VSNEDPDTDA NFTWTVPLVD 

      1330       1340       1350       1360       1370       1380 
LKAADGIMIR LYDSEDQPGY ENDNITLSVF MHTLQCNFWN EDQQEWDSTG CKVGPLSKPS 

      1390       1400       1410       1420       1430       1440 
TTHCLCNHLT GFFGSSILVP PNHAQPVIGG HKLTGVDFLI CVLIGYGIYC VALVIRVVGC 

      1450 
SFAIRVHKVL 

« Hide

References

[1]"The sea urchin sperm receptor for egg jelly is a modular protein with extensive homology to the human polycystic kidney disease protein, PKD1."
Moy G.W., Mendoza L.M., Schulz J.R., Swanson W.J., Glabe C.G., Vacquier V.D.
J. Cell Biol. 133:809-817(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE, VARIANTS ALA-440; PRO-593; MET-1204; SER-1371; ALA-1390 AND VAL-1443.
Tissue: Testis.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U40832 mRNA. Translation: AAB08448.1.
PIRT30273.
RefSeqNP_999773.1. NM_214608.1.
UniGeneSpu.212.

3D structure databases

ProteinModelPortalQ26627.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING7668.Q26627.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaSPU_023767-tr; SPU_023767-tr; SPU_023767.
GeneID373460.
KEGGspu:373460.

Organism-specific databases

CTD373460.

Phylogenomic databases

eggNOGNOG294369.
InParanoidQ26627.

Family and domain databases

Gene3D3.10.100.10. 2 hits.
InterProIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR000203. GPS.
IPR002859. PKD/REJ-like.
IPR014010. REJ-like.
[Graphical view]
PfamPF00008. EGF. 1 hit.
PF01825. GPS. 1 hit.
PF00059. Lectin_C. 2 hits.
PF02010. REJ. 1 hit.
[Graphical view]
SMARTSM00034. CLECT. 2 hits.
SM00181. EGF. 1 hit.
SM00303. GPS. 1 hit.
[Graphical view]
SUPFAMSSF56436. SSF56436. 2 hits.
PROSITEPS00010. ASX_HYDROXYL. 1 hit.
PS50041. C_TYPE_LECTIN_2. 2 hits.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS50221. GPS. 1 hit.
PS51111. REJ. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSUREJ_STRPU
AccessionPrimary (citable) accession number: Q26627
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: November 1, 1996
Last modified: March 19, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families