Sperm receptor for egg jelly precursor - Strongylocentrotus purpuratus (Purple sea urchin)

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Q26627 (SUREJ_STRPU) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 96. History...

Clusters with 100%, 90%, 50% identity |

Documents (1) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Sperm receptor for egg jelly
Short name=suREJ

Gene names

Name:

REJ

Organism

Strongylocentrotus purpuratus (Purple sea urchin) [Reference proteome]

Taxonomic identifier

Taxonomic lineage

Eukaryota › Metazoa › Echinodermata › Eleutherozoa › Echinozoa › Echinoidea › Euechinoidea › Echinacea › Echinoida › Strongylocentrotidae › Strongylocentrotus

Protein attributes

Sequence length	1450 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Receptor for the egg jelly ligands inducing the acrosome reaction. Could be a regulator of sperm ion channels.
Subcellular location	Cell membrane; Single-pass type I membrane protein. Note: Present on the surface of the sperm flagellum and also on a thin belt of membrane directly over the acrosomal granule at the anterior apex of the sperm head.
Developmental stage	Expressed at the earliest stage of spermiogenesis.
Sequence similarities	Belongs to the polycystin family. Contains 2 C-type lectin domains. Contains 1 EGF-like domain. Contains 1 GPS domain. Contains 1 REJ domain.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	EGF-like domain Repeat Signal Transmembrane Transmembrane helix
Ligand	Lectin
Molecular function	Receptor
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	neuropeptide signaling pathway Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	carbohydrate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

26

Potential

Chain

1424

Sperm receptor for egg jelly

PRO_0000024301

Regions

Topological domain

1388

Extracellular Potential

Transmembrane

21

Helical; Potential

Topological domain

15

Cytoplasmic Potential

Domain

37

EGF-like

Domain

114

C-type lectin 1

Domain

115

C-type lectin 2

Domain

720

REJ

Domain

51

GPS

Amino acid modifications

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Disulfide bond

By similarity

Disulfide bond

By similarity

Disulfide bond

By similarity

Disulfide bond

By similarity

Disulfide bond

By similarity

Disulfide bond

By similarity

Disulfide bond

By similarity

Disulfide bond

By similarity

Natural variations

Natural variant

1

V → A. Ref.1

Natural variant

1

A → P. Ref.1

Natural variant

1

I → M. Ref.1

Natural variant

1

C → S. Ref.1

Natural variant

1

T → A. Ref.1

Natural variant

1

A → V. Ref.1

Sequences

Sequence

Length

Mass (Da)

Tools

Q26627 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 66C322FB26F918F5
Show »

1,450

158,165

        10         20         30         40         50         60 
MSVFVILILF NAILNFKTVG PAAVSSKTVD CASAPCMNGG TCADGFNNFT CFCEEGFTGS 

        70         80         90        100        110        120 
MCETEYGCFR PWFYGPAFGY CYLWERVDYN WTQARESCID QGRGAELASI HSAEENAFVY 

       130        140        150        160        170        180 
AQIRRYAWIG LSDQVTEGVF DYADGTPVDY LSFPDKNKQS ETRDCVYVKH LRVDNWSLLD 

       190        200        210        220        230        240 
CRANKTSICK STTTFSATDG CATGWVHNPA TGYCYFYEER GGMWSKGREF CLDAGADLAS 

       250        260        270        280        290        300 
IHSAEENAFI FDMLTEFVWL GLNDLETEGV YTNFSDGTPA DFDNFPADNY QNEDHDCVSI 

       310        320        330        340        350        360 
RHLEKTDRYW FFLGCDDTVT SICKRPHEVV ATQAPPYLFT TTDVPATTTT IPTTTTTISA 

       370        380        390        400        410        420 
TTRTIDAMIL IELLLFPNNV SSIDNIFRVN NTILVTASVL GSFQALSSQI LWSITNHLSG 

       430        440        450        460        470        480 
DSVQYTVYSE DAVLVRFTTV SIFTIKATAV GNSHNLTATA NATVKHVCIS SLTTSVKEHC 

       490        500        510        520        530        540 
DAPHPAVYLR AFDIHISTHM ELNGKCIDPM TPDFKWRIFT STEADDVVTA FEKITHTRQV 

       550        560        570        580        590        600 
MIPRGTLPYG IYSLNLNAKT RLKTSGEVTG EKEIISWLEI QPPPLVAVIK GGASRSHGVS 

       610        620        630        640        650        660 
SNLIVDGSNS YDPDVPPGSS SNVTFLWYCV VVDPDVMYSS LDEAIQNTDN ACFEDEGIMM 

       670        680        690        700        710        720 
NSTSSMIEVI ANKLNANVTM NFWLNISKEG QISGLTQQRI HLTLGLLPEI EISCISNCNM 

       730        740        750        760        770        780 
YIFTAERLVL HASCTNCDSE NEDVSFRWSL ESNHTSVIGD LSSQTTTGLD QPYLVLKPLT 

       790        800        810        820        830        840 
FDSISEMGSI ILRVTGSQSD SDGYAEFSVD LPHNAPPALG SCVVTPDEGY ALQTDFTVTC 

       850        860        870        880        890        900 
SNFTDVDEPL TYQIILFSHV DVVDWMFVGR GEGFQLYEGS APIKDGLYLP VGVGTDDHDI 

       910        920        930        940        950        960 
LLQVNVRDCN MASTSVYISA TVHPPTLDAV GMNLVQELLD MALLVETNVN ALLAVGDPGQ 

       970        980        990       1000       1010       1020 
AAQLISALGS ILNSIGDEDD SEEGRETRSE IRSFLVDCVA AIPVESMTSL KQSSAALAVV 

      1030       1040       1050       1060       1070       1080 
THNKQEISTH VQMLAASTLS EMTSFVKSKS GSYTQAQENI ESAGTILVEG LSNILSAAKE 

      1090       1100       1110       1120       1130       1140 
TERLLSDDTS QEREDHKNLI EVAVSTINDI QDAIVAGKIP SEAATIITSP ALSIAVGSIS 

      1150       1160       1170       1180       1190       1200 
RDELAEATFG GPEDLGSFRM PSQDVLNQAM EHALGTTVSM KMSAMKWNPF SWPGAGGESI 

      1210       1220       1230       1240       1250       1260 
KSSIVGIQLE ADQMLEFHDL TADIDVYLPM RETLSADPVS VHITKTSSDS VLIDHSSLPV 

      1270       1280       1290       1300       1310       1320 
DGALHLTVIA ENEPMVALSI CTARISITES SCVGTDTPLG VSNEDPDTDA NFTWTVPLVD 

      1330       1340       1350       1360       1370       1380 
LKAADGIMIR LYDSEDQPGY ENDNITLSVF MHTLQCNFWN EDQQEWDSTG CKVGPLSKPS 

      1390       1400       1410       1420       1430       1440 
TTHCLCNHLT GFFGSSILVP PNHAQPVIGG HKLTGVDFLI CVLIGYGIYC VALVIRVVGC 

      1450 
SFAIRVHKVL

References

[1]

"The sea urchin sperm receptor for egg jelly is a modular protein with extensive homology to the human polycystic kidney disease protein, PKD1."
Moy G.W., Mendoza L.M., Schulz J.R., Swanson W.J., Glabe C.G., Vacquier V.D.
J. Cell Biol. 133:809-817(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE, VARIANTS ALA-440; PRO-593; MET-1204; SER-1371; ALA-1390 AND VAL-1443.
Tissue: Testis.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U40832 mRNA. Translation: AAB08448.1.
PIR	T30273.
RefSeq	NP_999773.1. NM_214608.1.
UniGene	Spu.212.
3D structure databases
ProteinModelPortal	Q26627.
ModBase	Search...
Protein-protein interaction databases
STRING	7668.Q26627.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	373460.
KEGG	spu:373460.
Organism-specific databases
CTD	373460.
Phylogenomic databases
eggNOG	NOG294369.
InParanoid	Q26627.
Family and domain databases
Gene3D	3.10.100.10. 2 hits.
InterPro	IPR001304. C-type_lectin. IPR016186. C-type_lectin-like. IPR016187. C-type_lectin_fold. IPR000742. EG-like_dom. IPR013032. EGF-like_CS. IPR000152. EGF-type_Asp/Asn_hydroxyl_site. IPR000203. GPS_dom. IPR002859. PKD/REJ-like. IPR014010. REJ-like. [Graphical view]
Pfam	PF00008. EGF. 1 hit. PF01825. GPS. 1 hit. PF00059. Lectin_C. 2 hits. PF02010. REJ. 1 hit. [Graphical view]
SMART	SM00034. CLECT. 2 hits. SM00181. EGF. 1 hit. SM00303. GPS. 1 hit. [Graphical view]
SUPFAM	SSF56436. C-type_lectin_fold. 2 hits.
PROSITE	PS00010. ASX_HYDROXYL. 1 hit. PS00615. C_TYPE_LECTIN_1. False negative. PS50041. C_TYPE_LECTIN_2. 2 hits. PS00022. EGF_1. 1 hit. PS01186. EGF_2. 1 hit. PS50026. EGF_3. 1 hit. PS50221. GPS. 1 hit. PS51111. REJ. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SUREJ_STRPU

Accession

Primary (citable) accession number: Q26627

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 10, 2002
Last sequence update:	November 1, 1996
Last modified:	April 3, 2013
This is version 96 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents