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Protein

cAMP-dependent protein kinase type II regulatory subunit

Gene
N/A
Organism
Strongylocentrotus purpuratus (Purple sea urchin)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei186 – 1861cAMP 1By similarity
Binding sitei195 – 1951cAMP 1By similarity
Binding sitei313 – 3131cAMP 2By similarity
Binding sitei322 – 3221cAMP 2By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi121 – 238118cAMP 1Add
BLAST
Nucleotide bindingi239 – 365127cAMP 2Add
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

cAMP, cAMP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
cAMP-dependent protein kinase type II regulatory subunit
OrganismiStrongylocentrotus purpuratus (Purple sea urchin)
Taxonomic identifieri7668 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEchinodermataEleutherozoaEchinozoaEchinoideaEuechinoideaEchinaceaEchinoidaStrongylocentrotidaeStrongylocentrotus
Proteomesi
  • UP000007110 Componenti: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 369369cAMP-dependent protein kinase type II regulatory subunitPRO_0000205398Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei81 – 811PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Tetramer, composed of 2 regulatory (R) and 2 catalytic (C) subunits. In the presence of cAMP it dissociates into 2 active monomeric C subunits and an R dimer (By similarity).By similarity

Protein-protein interaction databases

STRINGi7668.SPU_018419tr.

Structurei

3D structure databases

ProteinModelPortaliQ26619.
SMRiQ26619. Positions 4-41, 99-369.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 120120Dimerization and phosphorylationBy similarityAdd
BLAST

Sequence similaritiesi

Contains 2 cyclic nucleotide-binding domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1113. Eukaryota.
COG0664. LUCA.
KOiK04739.

Family and domain databases

Gene3Di2.60.120.10. 2 hits.
InterProiIPR012198. cAMP_dep_PK_reg_su.
IPR003117. cAMP_dep_PK_reg_su_I/II_a/b.
IPR018490. cNMP-bd-like.
IPR018488. cNMP-bd_CS.
IPR000595. cNMP-bd_dom.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 2 hits.
PF02197. RIIa. 1 hit.
[Graphical view]
PIRSFiPIRSF000548. PK_regulatory. 1 hit.
SMARTiSM00100. cNMP. 2 hits.
SM00394. RIIa. 1 hit.
[Graphical view]
SUPFAMiSSF47391. SSF47391. 1 hit.
SSF51206. SSF51206. 2 hits.
PROSITEiPS00888. CNMP_BINDING_1. 1 hit.
PS00889. CNMP_BINDING_2. 2 hits.
PS50042. CNMP_BINDING_3. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q26619-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNFEIPEGLT DLLQDFTVAV LREKPSDLVE FASSYFAKLQ ENNISLGGKR
60 70 80 90 100
GVTFTAPEDA ESDIDDEPPE LPKNRYARRK SVCAEKYDPE ADNDTDTQKL
110 120 130 140 150
VYPKSDEQRA RLTEAVKNIL LFRALDEKQM QEVIDAMFEK KTTPGDHVID
160 170 180 190 200
QGDDGDNFYV IDRGEYDIFV NDNKVGAYKD SGSFGELALM YNTPRAATIA
210 220 230 240 250
ATTDGILWAL DRVSFRRIVL KNAAKKRRIY EELLEKVSIF KSLEPYERMN
260 270 280 290 300
LADALVTRTY EDGDCIIAQG DGADGCYFIE AGQCRIAMKS ERSDNPDEEK
310 320 330 340 350
EVAIYNQGQY FGELALLTNK PRAASVYAVE DVDCLLDVNA FERLLGPCMD
360
IMKRNIEHYE QETSRLFGK
Length:369
Mass (Da):41,789
Last modified:November 1, 1996 - v1
Checksum:i30FCECC13D8C26A5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19887 mRNA. Translation: AAA61966.1.
RefSeqiNP_999688.1. NM_214523.1.
UniGeneiSpu.2225.

Genome annotation databases

GeneIDi373288.
KEGGispu:373288.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19887 mRNA. Translation: AAA61966.1.
RefSeqiNP_999688.1. NM_214523.1.
UniGeneiSpu.2225.

3D structure databases

ProteinModelPortaliQ26619.
SMRiQ26619. Positions 4-41, 99-369.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7668.SPU_018419tr.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi373288.
KEGGispu:373288.

Phylogenomic databases

eggNOGiKOG1113. Eukaryota.
COG0664. LUCA.
KOiK04739.

Family and domain databases

Gene3Di2.60.120.10. 2 hits.
InterProiIPR012198. cAMP_dep_PK_reg_su.
IPR003117. cAMP_dep_PK_reg_su_I/II_a/b.
IPR018490. cNMP-bd-like.
IPR018488. cNMP-bd_CS.
IPR000595. cNMP-bd_dom.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 2 hits.
PF02197. RIIa. 1 hit.
[Graphical view]
PIRSFiPIRSF000548. PK_regulatory. 1 hit.
SMARTiSM00100. cNMP. 2 hits.
SM00394. RIIa. 1 hit.
[Graphical view]
SUPFAMiSSF47391. SSF47391. 1 hit.
SSF51206. SSF51206. 2 hits.
PROSITEiPS00888. CNMP_BINDING_1. 1 hit.
PS00889. CNMP_BINDING_2. 2 hits.
PS50042. CNMP_BINDING_3. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKAPR_STRPU
AccessioniPrimary (citable) accession number: Q26619
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: November 11, 2015
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.