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Protein

Fibroblast growth factor receptor

Gene

FGFR

Organism
Strongylocentrotus purpuratus (Purple sea urchin)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for basic fibroblast growth factor.

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei673ATPPROSITE-ProRule annotation1
Active sitei781Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi645 – 653ATPPROSITE-ProRule annotation9

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Receptor, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor receptor (EC:2.7.10.1)
Short name:
SpFGFR
Gene namesi
Name:FGFR
OrganismiStrongylocentrotus purpuratus (Purple sea urchin)
Taxonomic identifieri7668 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEchinodermataEleutherozoaEchinozoaEchinoideaEuechinoideaEchinaceaEchinoidaStrongylocentrotidaeStrongylocentrotus
Proteomesi
  • UP000007110 Componenti: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini44 – 547ExtracellularSequence analysisAdd BLAST504
Transmembranei548 – 568HelicalSequence analysisAdd BLAST21
Topological domaini569 – 972CytoplasmicSequence analysisAdd BLAST404

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 43Sequence analysisAdd BLAST43
ChainiPRO_000024921444 – 972Fibroblast growth factor receptorAdd BLAST929

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi109N-linked (GlcNAc...)Sequence analysis1
Glycosylationi121N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi176 ↔ 226PROSITE-ProRule annotation
Glycosylationi191N-linked (GlcNAc...)Sequence analysis1
Glycosylationi203N-linked (GlcNAc...)Sequence analysis1
Glycosylationi239N-linked (GlcNAc...)Sequence analysis1
Glycosylationi272N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi306 ↔ 358PROSITE-ProRule annotation
Glycosylationi315N-linked (GlcNAc...)Sequence analysis1
Glycosylationi390N-linked (GlcNAc...)Sequence analysis1
Glycosylationi398N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi403 ↔ 501PROSITE-ProRule annotation
Glycosylationi419N-linked (GlcNAc...)Sequence analysis1
Glycosylationi422N-linked (GlcNAc...)Sequence analysis1
Glycosylationi460N-linked (GlcNAc...)Sequence analysis1
Modified residuei812Phosphotyrosine; by autocatalysisBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PRIDEiQ26614.

Expressioni

Developmental stagei

Transcripts accumulate when morphogenesis begins with mesenchyme cell ingression and gastrulation. Accumulation in all cell types of the embryo, although hybridization shows that they are somewhat enriched in cells of oral ectoderm and endoderm. Isoform 2 transcript is enriched in endomesoderm.

Interactioni

Protein-protein interaction databases

STRINGi7668.SPU_020677tr.

Structurei

3D structure databases

ProteinModelPortaliQ26614.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini57 – 152Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST96
Domaini150 – 242Ig-like C2-type 1Add BLAST93
Domaini282 – 374Ig-like C2-type 2Add BLAST93
Domaini383 – 517Ig-like C2-type 3Add BLAST135
Domaini639 – 925Protein kinasePROSITE-ProRule annotationAdd BLAST287

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi273 – 278Poly-Glu6

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.PROSITE-ProRule annotation
Contains 1 fibronectin type-III domain.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0200. Eukaryota.
COG0515. LUCA.
InParanoidiQ26614.
KOiK04362.

Family and domain databases

CDDicd00063. FN3. 1 hit.
Gene3Di2.60.40.10. 5 hits.
InterProiIPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF00041. fn3. 1 hit.
PF07679. I-set. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SMARTiSM00060. FN3. 1 hit.
SM00409. IG. 3 hits.
SM00408. IGc2. 3 hits.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 4 hits.
SSF49265. SSF49265. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50853. FN3. 1 hit.
PS50835. IG_LIKE. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q26614-1) [UniParc]FASTAAdd to basket
Also known as: Ig3L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSLPRCPRTR TVMFSRTLTR CYPQRTLWIA ILCVICSWTL STAGATTIRD
60 70 80 90 100
KEVKPDAPQD LTAIPVKAEA IVLTWKKPLK GQTDGYIVVY CLKRNKGNGC
110 120 130 140 150
ERQKIEGGNV TEVEVTNLYA NHTYQFQVQS WYSDHPKGAS TGYIEASGTP
160 170 180 190 200
PIPPTLRRNF KGLVEKSLGF EHKIPCPVKA DPRPYTRWLK NGTDLTPNDP
210 220 230 240 250
DDNVSFTKTS IVFKRLRFSD AGLYTCVASN FFGQPIHVNF TLIVVDTHSE
260 270 280 290 300
SYAESSVLES FSSLELETGP YNETEEEETH FPRFTDTERM EPEKPLPSNT
310 320 330 340 350
KVRLECGARG TPTPNITWIK DGVQKWKINV IRPTRVEEKG FVLIIRRAIV
360 370 380 390 400
RDTGKYTCIV SNQYGTIEHT YDVKIRERLP VKPIMSPMKN VTATVGSNTS
410 420 430 440 450
FVCRVVNDLT PHFAWMRFNG TNNTKQRLTD IDDHISILQQ RWVEEPMLTC
460 470 480 490 500
DEFLDVFYQN QSKRMLECLH LIQLETQGGM EEANQLKLYN VQYEDEGPYL
510 520 530 540 550
CVAGNFYGMS WEGAYLDVVE PTTQAPVRTN PPAVYIPNNM QPTSKTQLII
560 570 580 590 600
FSVVGFVVVL ILVTCIAILC KQTQVRHRRP SDKPDISGPK HLYRQTSVDS
610 620 630 640 650
TQSIAPLFGG RNRLTSSLTV ISEYDIPLDP EWEFPRDRLT VGKTIGEGAF
660 670 680 690 700
GKVVIGEAVG IVCQEKTSTV AVKMLKANAM DREFSDLISE LAMMKMIGKN
710 720 730 740 750
PNIINLLGCC TQEGPPYVIV EFAHHGNLRD FLRSRRPPEE YEKSILLTTS
760 770 780 790 800
QTLTNKDLMS MAYQVARGMD FLASKKCIHR DLAARNVLVT EDFEMKICDF
810 820 830 840 850
GLARDIHYID FYRKTTDGRL PVKWMAPEAL FDRMFTTQSD VWSFGILLWE
860 870 880 890 900
IMTLGGTPYP SVPVEQMFDY LRSGKRLEKP QNTSLEIYHI LCECWRTSPG
910 920 930 940 950
QRPTFCELVE DLDRIISVSS NQDYLDLEAV GDAPVKTFQE SERMAFMGFR
960 970
APLSPQVYYK VPQTRDCCPY AN
Length:972
Mass (Da):110,482
Last modified:November 1, 1996 - v1
Checksum:iE8F2FD841F4CF5E1
GO
Isoform 2 (identifier: Q26614-2) [UniParc]FASTAAdd to basket
Also known as: Ig3S

The sequence of this isoform differs from the canonical sequence as follows:
     439-472: Missing.

Show »
Length:938
Mass (Da):106,256
Checksum:i40E4624B393573A5
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_020370439 – 472Missing in isoform 2. 1 PublicationAdd BLAST34

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U17164 mRNA. Translation: AAC47258.1.
RefSeqiNP_999702.1. NM_214537.1. [Q26614-1]
UniGeneiSpu.199.

Genome annotation databases

GeneIDi373310.
KEGGispu:373310.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U17164 mRNA. Translation: AAC47258.1.
RefSeqiNP_999702.1. NM_214537.1. [Q26614-1]
UniGeneiSpu.199.

3D structure databases

ProteinModelPortaliQ26614.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7668.SPU_020677tr.

Proteomic databases

PRIDEiQ26614.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi373310.
KEGGispu:373310.

Organism-specific databases

CTDi373310.

Phylogenomic databases

eggNOGiKOG0200. Eukaryota.
COG0515. LUCA.
InParanoidiQ26614.
KOiK04362.

Family and domain databases

CDDicd00063. FN3. 1 hit.
Gene3Di2.60.40.10. 5 hits.
InterProiIPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF00041. fn3. 1 hit.
PF07679. I-set. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SMARTiSM00060. FN3. 1 hit.
SM00409. IG. 3 hits.
SM00408. IGc2. 3 hits.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 4 hits.
SSF49265. SSF49265. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50853. FN3. 1 hit.
PS50835. IG_LIKE. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFGFR_STRPU
AccessioniPrimary (citable) accession number: Q26614
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.