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Protein

77 kDa echinoderm microtubule-associated protein

Gene

EMAP

Organism
Strongylocentrotus purpuratus (Purple sea urchin)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic.

Names & Taxonomyi

Protein namesi
Recommended name:
77 kDa echinoderm microtubule-associated protein
Gene namesi
Name:EMAP
OrganismiStrongylocentrotus purpuratus (Purple sea urchin)
Taxonomic identifieri7668 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEchinodermataEleutherozoaEchinozoaEchinoideaEuechinoideaEchinaceaEchinoidaStrongylocentrotidaeStrongylocentrotus
Proteomesi
  • UP000007110 Componenti: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 68668677 kDa echinoderm microtubule-associated proteinPRO_0000050964Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi7668.SPU_005744tr.

Structurei

3D structure databases

ProteinModelPortaliQ26613.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati142 – 18948WD 1Add
BLAST
Repeati194 – 23744WD 2Add
BLAST
Repeati240 – 27940WD 3Add
BLAST
Repeati287 – 32539WD 4Add
BLAST
Repeati329 – 36840WD 5Add
BLAST
Repeati412 – 45140WD 6Add
BLAST
Repeati495 – 53440WD 7Add
BLAST
Repeati541 – 58040WD 8Add
BLAST
Repeati608 – 64740WD 9Add
BLAST
Repeati653 – 68533WD 10Add
BLAST

Sequence similaritiesi

Belongs to the WD repeat EMAP family.Curated
Contains 10 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG2106. Eukaryota.
ENOG410XNTQ. LUCA.
InParanoidiQ26613.
KOiK18595.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR005108. HELP.
IPR011044. Quino_amine_DH_bsu.
IPR011047. Quinoprotein_ADH-like_supfam.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF03451. HELP. 1 hit.
PF00400. WD40. 5 hits.
[Graphical view]
SMARTiSM00320. WD40. 9 hits.
[Graphical view]
SUPFAMiSSF50969. SSF50969. 1 hit.
SSF50998. SSF50998. 3 hits.
PROSITEiPS50082. WD_REPEATS_2. 4 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q26613-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNRPSTARP NSASPRRPNT PGRPSSARPG SGRTRASPRG GSAGGKRFSK
60 70 80 90 100
EPQHNAEEGY VRIYLRGRPV TNYLPSDVED YDLNAKHPAP TEKLKLDWVY
110 120 130 140 150
GYRGRDCRCN LYLLPTGEII YFMAAVVVLY NVEEQNQRHY TGHNDDVKSI
160 170 180 190 200
AVHPDSVTIA TGQVAGHDPD EGKPHVRIWN SITMETLHVL GLGFFDRAVC
210 220 230 240 250
ALSFSKVNVG VHLAAVDESN EHVLSVWDWK KEKKLSDTKS SQDPVLACEY
260 270 280 290 300
HPMNDEQIIT LGKGHIHFWN TTGGKLVKKS GIFEKYDKPK FVLSLAFTGN
310 320 330 340 350
GDVITGDSNG NMYIWGKGNT RISQAILGAH EGGIFSLCVM NDGQILSGGG
360 370 380 390 400
KDKKVILWTA DYQQSEVTQV TEATGPVRTL CKGKGEDFYV GTTRNAILSG
410 420 430 440 450
NMGGEFNTLV QAHTEELWGL ALHPTQGLFL TCGYDKNVIM WDFEQHKPMW
460 470 480 490 500
NKLMEDGCQS AGFHPSGAVV AIGMTSGRWV ALDVESQDLI TVHTDGKEQH
510 520 530 540 550
DIIRYSPDGN FLAVASHDNY IYIYSVTEEG RKYSKVGKCS GHSSFVTHID
560 570 580 590 600
WSADSTKLQS NSGDYELLFW DAATCKQIVI SKETRDVEWA TFTGVLGYPV
610 620 630 640 650
CGIWPEGSDG TDVNTTARSA NGNLLASGDD FGKINLFRYP VNHPKADCTS
660 670 680
FKGHSSHVTS VAFNGDSTKL ISTGGRDMSC MQWSVV
Length:686
Mass (Da):75,454
Last modified:November 1, 1996 - v1
Checksum:iF692A011309E07AC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U15551 mRNA. Translation: AAA61945.1.
PIRiA55665.
RefSeqiNP_999633.1. NM_214468.1.
UniGeneiSpu.1972.

Genome annotation databases

GeneIDi373186.
KEGGispu:373186.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U15551 mRNA. Translation: AAA61945.1.
PIRiA55665.
RefSeqiNP_999633.1. NM_214468.1.
UniGeneiSpu.1972.

3D structure databases

ProteinModelPortaliQ26613.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7668.SPU_005744tr.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi373186.
KEGGispu:373186.

Organism-specific databases

CTDi373186.

Phylogenomic databases

eggNOGiKOG2106. Eukaryota.
ENOG410XNTQ. LUCA.
InParanoidiQ26613.
KOiK18595.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR005108. HELP.
IPR011044. Quino_amine_DH_bsu.
IPR011047. Quinoprotein_ADH-like_supfam.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF03451. HELP. 1 hit.
PF00400. WD40. 5 hits.
[Graphical view]
SMARTiSM00320. WD40. 9 hits.
[Graphical view]
SUPFAMiSSF50969. SSF50969. 1 hit.
SSF50998. SSF50998. 3 hits.
PROSITEiPS50082. WD_REPEATS_2. 4 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEMAP_STRPU
AccessioniPrimary (citable) accession number: Q26613
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: November 1, 1996
Last modified: May 11, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.