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Q26609

- HXK_SCHMA

UniProt

Q26609 - HXK_SCHMA

Protein

Hexokinase

Gene
N/A
Organism
Schistosoma mansoni (Blood fluke)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 2 (14 Aug 2001)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + D-hexose = ADP + D-hexose 6-phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei144 – 1441Substrate; via carbonyl oxygen
    Binding sitei249 – 2491Substrate
    Binding sitei283 – 2831Substrate

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi74 – 796ATPSequence Analysis
    Nucleotide bindingi288 – 2892ATPBy similarity
    Nucleotide bindingi325 – 3295ATPBy similarity
    Nucleotide bindingi401 – 4055ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. hexokinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    SABIO-RKQ26609.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hexokinase (EC:2.7.1.1)
    OrganismiSchistosoma mansoni (Blood fluke)
    Taxonomic identifieri6183 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaPlatyhelminthesTrematodaDigeneaStrigeididaSchistosomatoideaSchistosomatidaeSchistosoma

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 451451HexokinasePRO_0000197599Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.1 Publication

    Structurei

    Secondary structure

    1
    451
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi5 – 1612
    Helixi17 – 193
    Helixi23 – 4119
    Helixi43 – 464
    Beta strandi68 – 8720
    Beta strandi95 – 1017
    Turni105 – 1095
    Helixi112 – 12918
    Beta strandi137 – 1437
    Beta strandi147 – 1504
    Turni151 – 1533
    Beta strandi154 – 1574
    Helixi174 – 18310
    Turni184 – 1863
    Beta strandi189 – 1957
    Helixi197 – 20610
    Beta strandi212 – 22918
    Turni230 – 2323
    Helixi234 – 2363
    Beta strandi240 – 2478
    Helixi250 – 2523
    Turni253 – 2564
    Turni258 – 2625
    Helixi265 – 2728
    Beta strandi274 – 2763
    Helixi283 – 2864
    Helixi288 – 30417
    Helixi309 – 3113
    Helixi316 – 3183
    Helixi327 – 3315
    Helixi340 – 3489
    Helixi357 – 38933
    Beta strandi392 – 4009
    Helixi401 – 4055
    Helixi409 – 42012
    Beta strandi426 – 4316
    Helixi435 – 44410

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1BDGX-ray2.60A1-451[»]
    ProteinModelPortaliQ26609.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ26609.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini8 – 208201Hexokinase type-1Add
    BLAST
    Domaini211 – 447237Hexokinase type-2Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni161 – 1622Substrate binding
    Regioni196 – 1972Substrate binding
    Regioni222 – 2232Substrate binding

    Sequence similaritiesi

    Belongs to the hexokinase family.Curated
    Contains 1 hexokinase type-1 domain.Curated
    Contains 1 hexokinase type-2 domain.Curated

    Phylogenomic databases

    HOGENOMiHOG000162670.
    KOiK00844.
    PhylomeDBiQ26609.

    Family and domain databases

    InterProiIPR001312. Hexokinase.
    IPR022673. Hexokinase_C.
    IPR019807. Hexokinase_CS.
    IPR022672. Hexokinase_N.
    [Graphical view]
    PANTHERiPTHR19443. PTHR19443. 1 hit.
    PfamiPF00349. Hexokinase_1. 1 hit.
    PF03727. Hexokinase_2. 1 hit.
    [Graphical view]
    PRINTSiPR00475. HEXOKINASE.
    PROSITEiPS00378. HEXOKINASES. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q26609-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVFSDQQLFE KVVEILKPFD LSVVDYEEIC DRMGESMRLG LQKSTNEKSS    50
    IKMFPSYVTK TPNGTETGNF LALDLGGTNY RVLSVTLEGK GKSPRIQERT 100
    YCIPAEKMSG SGTELFKYIA ETLADFLENN GMKDKKFDLG FTFSFPCVQK 150
    GLTHATLVRW TKGFSADGVE GHNVAELLQT ELDKRELNVK CVAVVNDTVG 200
    TLASCALEDP KCAVGLIVGT GTNVAYIEDS SKVELMDGVK EPEVVINTEW 250
    GAFGEKGELD CWRTQFDKSM DIDSLHPGKQ LYEKMVSGMY LGELVRHIIV 300
    YLVEQKILFR GDLPERLKVR NSLLTRYLTD VERDPAHLLY NTHYMLTDDL 350
    HVPVVEPIDN RIVRYACEMV VKRAAYLAGA GIACILRRIN RSEVTVGVDG 400
    SLYKFHPKFC ERMTDMVDKL KPKNTRFCLR LSEDGSGKGA AAIAASCTRQ 450
    N 451
    Length:451
    Mass (Da):50,446
    Last modified:August 14, 2001 - v2
    Checksum:i4CB6038AED0FF391
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L04480 Genomic DNA. Translation: AAA29894.2.
    UniGeneiSma.12420.

    Genome annotation databases

    KEGGismm:Smp_043030.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L04480 Genomic DNA. Translation: AAA29894.2 .
    UniGenei Sma.12420.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1BDG X-ray 2.60 A 1-451 [» ]
    ProteinModelPortali Q26609.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    KEGGi smm:Smp_043030.

    Phylogenomic databases

    HOGENOMi HOG000162670.
    KOi K00844.
    PhylomeDBi Q26609.

    Enzyme and pathway databases

    SABIO-RK Q26609.

    Miscellaneous databases

    EvolutionaryTracei Q26609.

    Family and domain databases

    InterProi IPR001312. Hexokinase.
    IPR022673. Hexokinase_C.
    IPR019807. Hexokinase_CS.
    IPR022672. Hexokinase_N.
    [Graphical view ]
    PANTHERi PTHR19443. PTHR19443. 1 hit.
    Pfami PF00349. Hexokinase_1. 1 hit.
    PF03727. Hexokinase_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00475. HEXOKINASE.
    PROSITEi PS00378. HEXOKINASES. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Schistosoma mansoni hexokinase: cDNA cloning and immunogenicity studies."
      Shoemaker C.B., Reynolds S., Wei G., Harn D.
      Exp. Parasitol. 80:36-45(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Puerto Rican.
    2. Shoemaker C.B., Reynolds S., Wei G., Harn D.
      Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION TO 33.
    3. Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) IN COMPLEX WITH GLUCOSE.

    Entry informationi

    Entry nameiHXK_SCHMA
    AccessioniPrimary (citable) accession number: Q26609
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: August 14, 2001
    Last modified: October 1, 2014
    This is version 77 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    3D-structure

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3