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Q26609 (HXK_SCHMA) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hexokinase

EC=2.7.1.1
OrganismSchistosoma mansoni (Blood fluke)
Taxonomic identifier6183 [NCBI]
Taxonomic lineageEukaryotaMetazoaPlatyhelminthesTrematodaDigeneaStrigeididaSchistosomatoideaSchistosomatidaeSchistosoma

Protein attributes

Sequence length451 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

ATP + D-hexose = ADP + D-hexose 6-phosphate.

Subunit structure

Monomer.

Sequence similarities

Belongs to the hexokinase family.

Contains 1 hexokinase type-1 domain.

Contains 1 hexokinase type-2 domain.

Ontologies

Keywords
   Biological processGlycolysis
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical term3D-structure
Gene Ontology (GO)
   Biological_processglycolytic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

hexokinase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 451451Hexokinase
PRO_0000197599

Regions

Domain8 – 208201Hexokinase type-1
Domain211 – 447237Hexokinase type-2
Nucleotide binding74 – 796ATP Potential
Nucleotide binding288 – 2892ATP By similarity
Nucleotide binding325 – 3295ATP By similarity
Nucleotide binding401 – 4055ATP By similarity
Region161 – 1622Substrate binding
Region196 – 1972Substrate binding
Region222 – 2232Substrate binding

Sites

Binding site1441Substrate; via carbonyl oxygen
Binding site2491Substrate
Binding site2831Substrate

Secondary structure

.................................................................... 451
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q26609 [UniParc].

Last modified August 14, 2001. Version 2.
Checksum: 4CB6038AED0FF391

FASTA45150,446
        10         20         30         40         50         60 
MVFSDQQLFE KVVEILKPFD LSVVDYEEIC DRMGESMRLG LQKSTNEKSS IKMFPSYVTK 

        70         80         90        100        110        120 
TPNGTETGNF LALDLGGTNY RVLSVTLEGK GKSPRIQERT YCIPAEKMSG SGTELFKYIA 

       130        140        150        160        170        180 
ETLADFLENN GMKDKKFDLG FTFSFPCVQK GLTHATLVRW TKGFSADGVE GHNVAELLQT 

       190        200        210        220        230        240 
ELDKRELNVK CVAVVNDTVG TLASCALEDP KCAVGLIVGT GTNVAYIEDS SKVELMDGVK 

       250        260        270        280        290        300 
EPEVVINTEW GAFGEKGELD CWRTQFDKSM DIDSLHPGKQ LYEKMVSGMY LGELVRHIIV 

       310        320        330        340        350        360 
YLVEQKILFR GDLPERLKVR NSLLTRYLTD VERDPAHLLY NTHYMLTDDL HVPVVEPIDN 

       370        380        390        400        410        420 
RIVRYACEMV VKRAAYLAGA GIACILRRIN RSEVTVGVDG SLYKFHPKFC ERMTDMVDKL 

       430        440        450 
KPKNTRFCLR LSEDGSGKGA AAIAASCTRQ N 

« Hide

References

[1]"Schistosoma mansoni hexokinase: cDNA cloning and immunogenicity studies."
Shoemaker C.B., Reynolds S., Wei G., Harn D.
Exp. Parasitol. 80:36-45(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Puerto Rican.
[2]Shoemaker C.B., Reynolds S., Wei G., Harn D.
Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION TO 33.
[3]"The structure of mammalian hexokinase-1."
Mulichak A.M., Wilson J.E., Padmanabhan K., Garavito R.M.
Nat. Struct. Biol. 5:555-560(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) IN COMPLEX WITH GLUCOSE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L04480 Genomic DNA. Translation: AAA29894.2.
UniGeneSma.12420.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1BDGX-ray2.60A1-451[»]
ProteinModelPortalQ26609.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

KEGGsmm:Smp_043030.

Organism-specific databases

CTD8347871.

Phylogenomic databases

HOGENOMHOG000162670.
KOK00844.
PhylomeDBQ26609.

Enzyme and pathway databases

SABIO-RKQ26609.

Family and domain databases

InterProIPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR019807. Hexokinase_CS.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERPTHR19443. PTHR19443. 1 hit.
PfamPF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view]
PRINTSPR00475. HEXOKINASE.
PROSITEPS00378. HEXOKINASES. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ26609.

Entry information

Entry nameHXK_SCHMA
AccessionPrimary (citable) accession number: Q26609
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: August 14, 2001
Last modified: July 9, 2014
This is version 75 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references