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Protein

Hexokinase

Gene
N/A
Organism
Schistosoma mansoni (Blood fluke)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + D-hexose = ADP + D-hexose 6-phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei144Substrate; via carbonyl oxygen1
Binding sitei249Substrate1
Binding sitei283Substrate1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi74 – 79ATPSequence analysis6
Nucleotide bindingi288 – 289ATPBy similarity2
Nucleotide bindingi325 – 329ATPBy similarity5
Nucleotide bindingi401 – 405ATPBy similarity5

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

SABIO-RKQ26609.

Names & Taxonomyi

Protein namesi
Recommended name:
Hexokinase (EC:2.7.1.1)
OrganismiSchistosoma mansoni (Blood fluke)
Taxonomic identifieri6183 [NCBI]
Taxonomic lineageiEukaryotaMetazoaPlatyhelminthesTrematodaDigeneaStrigeididaSchistosomatoideaSchistosomatidaeSchistosoma

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001975991 – 451HexokinaseAdd BLAST451

Expressioni

Gene expression databases

ExpressionAtlasiQ26609. differential.

Interactioni

Subunit structurei

Monomer.1 Publication

Protein-protein interaction databases

STRINGi6183.Smp_043030__mRNA.

Structurei

Secondary structure

1451
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi5 – 16Combined sources12
Helixi17 – 19Combined sources3
Helixi23 – 41Combined sources19
Helixi43 – 46Combined sources4
Beta strandi68 – 87Combined sources20
Beta strandi95 – 101Combined sources7
Turni105 – 109Combined sources5
Helixi112 – 129Combined sources18
Beta strandi137 – 143Combined sources7
Beta strandi147 – 150Combined sources4
Turni151 – 153Combined sources3
Beta strandi154 – 157Combined sources4
Helixi174 – 183Combined sources10
Turni184 – 186Combined sources3
Beta strandi189 – 195Combined sources7
Helixi197 – 206Combined sources10
Beta strandi212 – 229Combined sources18
Turni230 – 232Combined sources3
Helixi234 – 236Combined sources3
Beta strandi240 – 247Combined sources8
Helixi250 – 252Combined sources3
Turni253 – 256Combined sources4
Turni258 – 262Combined sources5
Helixi265 – 272Combined sources8
Beta strandi274 – 276Combined sources3
Helixi283 – 286Combined sources4
Helixi288 – 304Combined sources17
Helixi309 – 311Combined sources3
Helixi316 – 318Combined sources3
Helixi327 – 331Combined sources5
Helixi340 – 348Combined sources9
Helixi357 – 389Combined sources33
Beta strandi392 – 400Combined sources9
Helixi401 – 405Combined sources5
Helixi409 – 420Combined sources12
Beta strandi426 – 431Combined sources6
Helixi435 – 444Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BDGX-ray2.60A1-451[»]
ProteinModelPortaliQ26609.
SMRiQ26609.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ26609.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 445HexokinasePROSITE-ProRule annotationAdd BLAST440

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni63 – 195Hexokinase small subdomainPROSITE-ProRule annotationAdd BLAST133
Regioni161 – 162Substrate binding2
Regioni196 – 434Hexokinase large subdomainPROSITE-ProRule annotationAdd BLAST239
Regioni196 – 197Substrate binding2
Regioni222 – 223Substrate binding2

Sequence similaritiesi

Belongs to the hexokinase family.PROSITE-ProRule annotationCurated
Contains 1 hexokinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1369. Eukaryota.
COG5026. LUCA.
HOGENOMiHOG000162670.
OMAiGQPFQNG.
OrthoDBiEOG091G08MD.
PhylomeDBiQ26609.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR019807. Hexokinase_BS.
IPR022673. Hexokinase_C.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view]
PROSITEiPS00378. HEXOKINASE_1. 1 hit.
PS51748. HEXOKINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q26609-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVFSDQQLFE KVVEILKPFD LSVVDYEEIC DRMGESMRLG LQKSTNEKSS
60 70 80 90 100
IKMFPSYVTK TPNGTETGNF LALDLGGTNY RVLSVTLEGK GKSPRIQERT
110 120 130 140 150
YCIPAEKMSG SGTELFKYIA ETLADFLENN GMKDKKFDLG FTFSFPCVQK
160 170 180 190 200
GLTHATLVRW TKGFSADGVE GHNVAELLQT ELDKRELNVK CVAVVNDTVG
210 220 230 240 250
TLASCALEDP KCAVGLIVGT GTNVAYIEDS SKVELMDGVK EPEVVINTEW
260 270 280 290 300
GAFGEKGELD CWRTQFDKSM DIDSLHPGKQ LYEKMVSGMY LGELVRHIIV
310 320 330 340 350
YLVEQKILFR GDLPERLKVR NSLLTRYLTD VERDPAHLLY NTHYMLTDDL
360 370 380 390 400
HVPVVEPIDN RIVRYACEMV VKRAAYLAGA GIACILRRIN RSEVTVGVDG
410 420 430 440 450
SLYKFHPKFC ERMTDMVDKL KPKNTRFCLR LSEDGSGKGA AAIAASCTRQ

N
Length:451
Mass (Da):50,446
Last modified:August 14, 2001 - v2
Checksum:i4CB6038AED0FF391
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L04480 Genomic DNA. Translation: AAA29894.2.

Genome annotation databases

EnsemblMetazoaiSmp_043030.1; Smp_043030.1:pep; Smp_043030.
GeneDBiSmp_043030.1:pep.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L04480 Genomic DNA. Translation: AAA29894.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BDGX-ray2.60A1-451[»]
ProteinModelPortaliQ26609.
SMRiQ26609.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6183.Smp_043030__mRNA.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiSmp_043030.1; Smp_043030.1:pep; Smp_043030.
GeneDBiSmp_043030.1:pep.

Phylogenomic databases

eggNOGiKOG1369. Eukaryota.
COG5026. LUCA.
HOGENOMiHOG000162670.
OMAiGQPFQNG.
OrthoDBiEOG091G08MD.
PhylomeDBiQ26609.

Enzyme and pathway databases

SABIO-RKQ26609.

Miscellaneous databases

EvolutionaryTraceiQ26609.

Gene expression databases

ExpressionAtlasiQ26609. differential.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR019807. Hexokinase_BS.
IPR022673. Hexokinase_C.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view]
PROSITEiPS00378. HEXOKINASE_1. 1 hit.
PS51748. HEXOKINASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHXK_SCHMA
AccessioniPrimary (citable) accession number: Q26609
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: August 14, 2001
Last modified: November 30, 2016
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.