Reviewed, UniProtKB/Swiss-Prot Q26609 (HXK_SCHMA)

Names and origin

Protein names	Recommended name:     Hexokinase     EC=2.7.1.1
Organism	Schistosoma mansoni (Blood fluke)
Taxonomic identifier	6183 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Platyhelminthes › Trematoda › Digenea › Strigeidida › Schistosomatoidea › Schistosomatidae › Schistosoma

Protein attributes

Sequence length	451 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Catalytic activity	ATP + D-hexose = ADP + D-hexose 6-phosphate.
Subunit structure	Monomer.
Sequence similarities	Belongs to the hexokinase family.

Ontologies

Keywords
Biological process	Glycolysis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	3D-structure
Gene Ontology (GO)
Biological process	glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW hexokinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 451

451

Hexokinase

PRO_0000197599

Regions

Nucleotide binding

74 – 79

6

ATP Potential

Nucleotide binding

288 – 289

2

ATP By similarity

Nucleotide binding

325 – 329

5

ATP By similarity

Nucleotide binding

401 – 405

5

ATP By similarity

Region

161 – 162

2

Substrate binding

Region

196 – 197

2

Substrate binding

Region

222 – 223

2

Substrate binding

Sites

Binding site

144

1

Substrate; via carbonyl oxygen

Binding site

249

1

Substrate

Binding site

283

1

Substrate

Secondary structure

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451

Helix Strand Turn

Details...

Helix

5 – 16

12

Helix

17 – 19

3

Helix

23 – 41

19

Helix

43 – 46

4

Beta strand

68 – 87

20

Beta strand

95 – 101

7

Turn

105 – 109

5

Helix

112 – 129

18

Beta strand

137 – 143

7

Beta strand

147 – 150

4

Turn

151 – 153

3

Beta strand

154 – 157

4

Helix

174 – 183

10

Turn

184 – 186

3

Beta strand

189 – 195

7

Helix

197 – 206

10

Beta strand

212 – 229

18

Turn

230 – 232

3

Helix

234 – 236

3

Beta strand

240 – 247

8

Helix

250 – 252

3

Turn

253 – 256

4

Turn

258 – 262

5

Helix

265 – 272

8

Beta strand

274 – 276

3

Helix

283 – 286

4

Helix

288 – 304

17

Helix

309 – 311

3

Helix

316 – 318

3

Helix

327 – 331

5

Helix

340 – 348

9

Beta strand

353 – 355

3

Helix

357 – 389

33

Beta strand

392 – 400

9

Helix

401 – 405

5

Helix

409 – 420

12

Beta strand

426 – 431

6

Helix

435 – 444

10

Sequences

	Sequence		Length	Mass (Da)
	Q26609-1 [UniParc]. Last modified August 14, 2001. Version 2. Checksum: 4CB6038AED0FF391	FASTA	451	50,446
	10 20 30 40 50 60 MVFSDQQLFE KVVEILKPFD LSVVDYEEIC DRMGESMRLG LQKSTNEKSS IKMFPSYVTK 70 80 90 100 110 120 TPNGTETGNF LALDLGGTNY RVLSVTLEGK GKSPRIQERT YCIPAEKMSG SGTELFKYIA 130 140 150 160 170 180 ETLADFLENN GMKDKKFDLG FTFSFPCVQK GLTHATLVRW TKGFSADGVE GHNVAELLQT 190 200 210 220 230 240 ELDKRELNVK CVAVVNDTVG TLASCALEDP KCAVGLIVGT GTNVAYIEDS SKVELMDGVK 250 260 270 280 290 300 EPEVVINTEW GAFGEKGELD CWRTQFDKSM DIDSLHPGKQ LYEKMVSGMY LGELVRHIIV 310 320 330 340 350 360 YLVEQKILFR GDLPERLKVR NSLLTRYLTD VERDPAHLLY NTHYMLTDDL HVPVVEPIDN 370 380 390 400 410 420 RIVRYACEMV VKRAAYLAGA GIACILRRIN RSEVTVGVDG SLYKFHPKFC ERMTDMVDKL 430 440 450 KPKNTRFCLR LSEDGSGKGA AAIAASCTRQ N

References

[1]	"Schistosoma mansoni hexokinase: cDNA cloning and immunogenicity studies." Shoemaker C.B., Reynolds S., Wei G., Harn D. Exp. Parasitol. 80:36-45(1995) [PubMed: 7821409] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Puerto Rican.
[2]	Shoemaker C.B., Reynolds S., Wei G., Harn D. Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION TO 33.
[3]	"The structure of mammalian hexokinase-1." Mulichak A.M., Wilson J.E., Padmanabhan K., Garavito R.M. Nat. Struct. Biol. 5:555-560(1998) [PubMed: 9665168] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) IN COMPLEX WITH GLUCOSE.

Cross-references

Sequence databases

EMBLGenBankDDBJ

L04480 Genomic DNA. Translation: AAA29894.2.

RefSeq

XP_002575647.1.

3D structure databases

PDBPDBe

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1BDG	X-ray	2.60	A	1-451	[»]

ModBase

Search...

Genome annotation databases

GeneID

8347871.

Enzyme and pathway databases

BRENDA

2.7.1.1. 1460.

Family and domain databases

InterPro

IPR001312. Hexokinase.
IPR019807. Hexokinase_CS.
[Graphical view]

PANTHER

PTHR19443. Hexokinase. 1 hit.

Pfam

PF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view]

PRINTS

PR00475. HEXOKINASE.

ProDom

PD001109. Hexokinase. 1 hit.
[Graphical view] [Entries sharing at least one domain]

PROSITE

PS00378. HEXOKINASES. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

HXK_SCHMA

Accession

Primary (citable) accession number: Q26609

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	August 14, 2001
Last modified:	October 13, 2009
This is version 51 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)