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Q26609

- HXK_SCHMA

UniProt

Q26609 - HXK_SCHMA

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Protein

Hexokinase

Gene
N/A
Organism
Schistosoma mansoni (Blood fluke)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + D-hexose = ADP + D-hexose 6-phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei144 – 1441Substrate; via carbonyl oxygen
Binding sitei249 – 2491Substrate
Binding sitei283 – 2831Substrate

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi74 – 796ATPSequence Analysis
Nucleotide bindingi288 – 2892ATPBy similarity
Nucleotide bindingi325 – 3295ATPBy similarity
Nucleotide bindingi401 – 4055ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. hexokinase activity Source: UniProtKB-EC

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

SABIO-RKQ26609.

Names & Taxonomyi

Protein namesi
Recommended name:
Hexokinase (EC:2.7.1.1)
OrganismiSchistosoma mansoni (Blood fluke)
Taxonomic identifieri6183 [NCBI]
Taxonomic lineageiEukaryotaMetazoaPlatyhelminthesTrematodaDigeneaStrigeididaSchistosomatoideaSchistosomatidaeSchistosoma

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 451451HexokinasePRO_0000197599Add
BLAST

Interactioni

Subunit structurei

Monomer.1 Publication

Structurei

Secondary structure

1
451
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi5 – 1612
Helixi17 – 193
Helixi23 – 4119
Helixi43 – 464
Beta strandi68 – 8720
Beta strandi95 – 1017
Turni105 – 1095
Helixi112 – 12918
Beta strandi137 – 1437
Beta strandi147 – 1504
Turni151 – 1533
Beta strandi154 – 1574
Helixi174 – 18310
Turni184 – 1863
Beta strandi189 – 1957
Helixi197 – 20610
Beta strandi212 – 22918
Turni230 – 2323
Helixi234 – 2363
Beta strandi240 – 2478
Helixi250 – 2523
Turni253 – 2564
Turni258 – 2625
Helixi265 – 2728
Beta strandi274 – 2763
Helixi283 – 2864
Helixi288 – 30417
Helixi309 – 3113
Helixi316 – 3183
Helixi327 – 3315
Helixi340 – 3489
Helixi357 – 38933
Beta strandi392 – 4009
Helixi401 – 4055
Helixi409 – 42012
Beta strandi426 – 4316
Helixi435 – 44410

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1BDGX-ray2.60A1-451[»]
ProteinModelPortaliQ26609.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ26609.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 208201Hexokinase type-1Add
BLAST
Domaini211 – 447237Hexokinase type-2Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni161 – 1622Substrate binding
Regioni196 – 1972Substrate binding
Regioni222 – 2232Substrate binding

Sequence similaritiesi

Belongs to the hexokinase family.Curated
Contains 1 hexokinase type-1 domain.Curated
Contains 1 hexokinase type-2 domain.Curated

Phylogenomic databases

HOGENOMiHOG000162670.
KOiK00844.
PhylomeDBiQ26609.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR019807. Hexokinase_CS.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view]
PRINTSiPR00475. HEXOKINASE.
PROSITEiPS00378. HEXOKINASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q26609-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVFSDQQLFE KVVEILKPFD LSVVDYEEIC DRMGESMRLG LQKSTNEKSS
60 70 80 90 100
IKMFPSYVTK TPNGTETGNF LALDLGGTNY RVLSVTLEGK GKSPRIQERT
110 120 130 140 150
YCIPAEKMSG SGTELFKYIA ETLADFLENN GMKDKKFDLG FTFSFPCVQK
160 170 180 190 200
GLTHATLVRW TKGFSADGVE GHNVAELLQT ELDKRELNVK CVAVVNDTVG
210 220 230 240 250
TLASCALEDP KCAVGLIVGT GTNVAYIEDS SKVELMDGVK EPEVVINTEW
260 270 280 290 300
GAFGEKGELD CWRTQFDKSM DIDSLHPGKQ LYEKMVSGMY LGELVRHIIV
310 320 330 340 350
YLVEQKILFR GDLPERLKVR NSLLTRYLTD VERDPAHLLY NTHYMLTDDL
360 370 380 390 400
HVPVVEPIDN RIVRYACEMV VKRAAYLAGA GIACILRRIN RSEVTVGVDG
410 420 430 440 450
SLYKFHPKFC ERMTDMVDKL KPKNTRFCLR LSEDGSGKGA AAIAASCTRQ

N
Length:451
Mass (Da):50,446
Last modified:August 14, 2001 - v2
Checksum:i4CB6038AED0FF391
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L04480 Genomic DNA. Translation: AAA29894.2.

Genome annotation databases

KEGGismm:Smp_043030.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L04480 Genomic DNA. Translation: AAA29894.2 .

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1BDG X-ray 2.60 A 1-451 [» ]
ProteinModelPortali Q26609.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

KEGGi smm:Smp_043030.

Phylogenomic databases

HOGENOMi HOG000162670.
KOi K00844.
PhylomeDBi Q26609.

Enzyme and pathway databases

SABIO-RK Q26609.

Miscellaneous databases

EvolutionaryTracei Q26609.

Family and domain databases

InterProi IPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR019807. Hexokinase_CS.
IPR022672. Hexokinase_N.
[Graphical view ]
PANTHERi PTHR19443. PTHR19443. 1 hit.
Pfami PF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view ]
PRINTSi PR00475. HEXOKINASE.
PROSITEi PS00378. HEXOKINASES. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Schistosoma mansoni hexokinase: cDNA cloning and immunogenicity studies."
    Shoemaker C.B., Reynolds S., Wei G., Harn D.
    Exp. Parasitol. 80:36-45(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Puerto Rican.
  2. Shoemaker C.B., Reynolds S., Wei G., Harn D.
    Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION TO 33.
  3. Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) IN COMPLEX WITH GLUCOSE.

Entry informationi

Entry nameiHXK_SCHMA
AccessioniPrimary (citable) accession number: Q26609
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: August 14, 2001
Last modified: October 29, 2014
This is version 78 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3