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Protein

Hexokinase

Gene
N/A
Organism
Schistosoma mansoni (Blood fluke)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + D-hexose = ADP + D-hexose 6-phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei144 – 1441Substrate; via carbonyl oxygen
Binding sitei249 – 2491Substrate
Binding sitei283 – 2831Substrate

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi74 – 796ATPSequence Analysis
Nucleotide bindingi288 – 2892ATPBy similarity
Nucleotide bindingi325 – 3295ATPBy similarity
Nucleotide bindingi401 – 4055ATPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

SABIO-RKQ26609.

Names & Taxonomyi

Protein namesi
Recommended name:
Hexokinase (EC:2.7.1.1)
OrganismiSchistosoma mansoni (Blood fluke)
Taxonomic identifieri6183 [NCBI]
Taxonomic lineageiEukaryotaMetazoaPlatyhelminthesTrematodaDigeneaStrigeididaSchistosomatoideaSchistosomatidaeSchistosoma

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 451451HexokinasePRO_0000197599Add
BLAST

Interactioni

Subunit structurei

Monomer.1 Publication

Protein-protein interaction databases

STRINGi6183.Smp_043030__mRNA.

Structurei

Secondary structure

1
451
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi5 – 1612Combined sources
Helixi17 – 193Combined sources
Helixi23 – 4119Combined sources
Helixi43 – 464Combined sources
Beta strandi68 – 8720Combined sources
Beta strandi95 – 1017Combined sources
Turni105 – 1095Combined sources
Helixi112 – 12918Combined sources
Beta strandi137 – 1437Combined sources
Beta strandi147 – 1504Combined sources
Turni151 – 1533Combined sources
Beta strandi154 – 1574Combined sources
Helixi174 – 18310Combined sources
Turni184 – 1863Combined sources
Beta strandi189 – 1957Combined sources
Helixi197 – 20610Combined sources
Beta strandi212 – 22918Combined sources
Turni230 – 2323Combined sources
Helixi234 – 2363Combined sources
Beta strandi240 – 2478Combined sources
Helixi250 – 2523Combined sources
Turni253 – 2564Combined sources
Turni258 – 2625Combined sources
Helixi265 – 2728Combined sources
Beta strandi274 – 2763Combined sources
Helixi283 – 2864Combined sources
Helixi288 – 30417Combined sources
Helixi309 – 3113Combined sources
Helixi316 – 3183Combined sources
Helixi327 – 3315Combined sources
Helixi340 – 3489Combined sources
Helixi357 – 38933Combined sources
Beta strandi392 – 4009Combined sources
Helixi401 – 4055Combined sources
Helixi409 – 42012Combined sources
Beta strandi426 – 4316Combined sources
Helixi435 – 44410Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1BDGX-ray2.60A1-451[»]
ProteinModelPortaliQ26609.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ26609.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 445440HexokinasePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni63 – 195133Hexokinase small subdomainPROSITE-ProRule annotationAdd
BLAST
Regioni161 – 1622Substrate binding
Regioni196 – 434239Hexokinase large subdomainPROSITE-ProRule annotationAdd
BLAST
Regioni196 – 1972Substrate binding
Regioni222 – 2232Substrate binding

Sequence similaritiesi

Belongs to the hexokinase family.PROSITE-ProRule annotationCurated
Contains 1 hexokinase domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000162670.
OMAiMATSIVF.
PhylomeDBiQ26609.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR019807. Hexokinase_BS.
IPR022673. Hexokinase_C.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view]
PROSITEiPS00378. HEXOKINASE_1. 1 hit.
PS51748. HEXOKINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q26609-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVFSDQQLFE KVVEILKPFD LSVVDYEEIC DRMGESMRLG LQKSTNEKSS
60 70 80 90 100
IKMFPSYVTK TPNGTETGNF LALDLGGTNY RVLSVTLEGK GKSPRIQERT
110 120 130 140 150
YCIPAEKMSG SGTELFKYIA ETLADFLENN GMKDKKFDLG FTFSFPCVQK
160 170 180 190 200
GLTHATLVRW TKGFSADGVE GHNVAELLQT ELDKRELNVK CVAVVNDTVG
210 220 230 240 250
TLASCALEDP KCAVGLIVGT GTNVAYIEDS SKVELMDGVK EPEVVINTEW
260 270 280 290 300
GAFGEKGELD CWRTQFDKSM DIDSLHPGKQ LYEKMVSGMY LGELVRHIIV
310 320 330 340 350
YLVEQKILFR GDLPERLKVR NSLLTRYLTD VERDPAHLLY NTHYMLTDDL
360 370 380 390 400
HVPVVEPIDN RIVRYACEMV VKRAAYLAGA GIACILRRIN RSEVTVGVDG
410 420 430 440 450
SLYKFHPKFC ERMTDMVDKL KPKNTRFCLR LSEDGSGKGA AAIAASCTRQ

N
Length:451
Mass (Da):50,446
Last modified:August 14, 2001 - v2
Checksum:i4CB6038AED0FF391
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L04480 Genomic DNA. Translation: AAA29894.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L04480 Genomic DNA. Translation: AAA29894.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1BDGX-ray2.60A1-451[»]
ProteinModelPortaliQ26609.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6183.Smp_043030__mRNA.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOGENOMiHOG000162670.
OMAiMATSIVF.
PhylomeDBiQ26609.

Enzyme and pathway databases

SABIO-RKQ26609.

Miscellaneous databases

EvolutionaryTraceiQ26609.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR019807. Hexokinase_BS.
IPR022673. Hexokinase_C.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view]
PROSITEiPS00378. HEXOKINASE_1. 1 hit.
PS51748. HEXOKINASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Schistosoma mansoni hexokinase: cDNA cloning and immunogenicity studies."
    Shoemaker C.B., Reynolds S., Wei G., Harn D.
    Exp. Parasitol. 80:36-45(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Puerto Rican.
  2. Shoemaker C.B., Reynolds S., Wei G., Harn D.
    Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION TO 33.
  3. Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) IN COMPLEX WITH GLUCOSE.

Entry informationi

Entry nameiHXK_SCHMA
AccessioniPrimary (citable) accession number: Q26609
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: August 14, 2001
Last modified: June 24, 2015
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.