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Protein

Homeobox protein engrailed-like SMOX-2

Gene

SMOX-2

Organism
Schistosoma mansoni (Blood fluke)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi423 – 482HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein engrailed-like SMOX-2
Gene namesi
Name:SMOX-2
OrganismiSchistosoma mansoni (Blood fluke)
Taxonomic identifieri6183 [NCBI]
Taxonomic lineageiEukaryotaMetazoaPlatyhelminthesTrematodaDigeneaStrigeididaSchistosomatoideaSchistosomatidaeSchistosoma

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001960891 – 524Homeobox protein engrailed-like SMOX-2Add BLAST524

Interactioni

Protein-protein interaction databases

STRINGi6183.Smp_145200__mRNA.

Structurei

3D structure databases

ProteinModelPortaliQ26601.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi104 – 121Poly-ThrAdd BLAST18
Compositional biasi194 – 211Poly-SerAdd BLAST18
Compositional biasi216 – 219Poly-Ser4
Compositional biasi324 – 334Asp/Glu-rich (acidic)Add BLAST11
Compositional biasi324 – 327Poly-Glu4
Compositional biasi507 – 517Asp/Glu-rich (acidic)Add BLAST11

Sequence similaritiesi

Belongs to the engrailed homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0493. Eukaryota.
ENOG4111P06. LUCA.
OrthoDBiEOG091G0XBB.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR019549. Homeobox-engrailed_C-terminal.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000747. Homeodomain_engrailed.
IPR019737. Homoebox-engrailed_CS.
[Graphical view]
PfamiPF10525. Engrail_1_C_sig. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00026. ENGRAILED.
PR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00033. ENGRAILED. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q26601-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFKLLDNFNE KSKSIMIEQM KQQYCLLQYD KEMVTNFLNF INHHYIWNCY
60 70 80 90 100
HNNSNNSYNN DLDMNNIQEK LIIEHLDPLM LINSYTDYPF WSSMLMLAVN
110 120 130 140 150
EAVTTTTTTT TTTTTSTTTT TSGIIPLSST IIPSTIISPV KTSLSSLSMM
160 170 180 190 200
TIDDLQNDIS KINYEEDFFS KLLKCTLIRN ENSYSNEIEQ LSLSSSSSSS
210 220 230 240 250
SSSSSSSSSS SCSTNSSSSV YMSEKKANGF FVKDILSFDK HKVIRRQKTD
260 270 280 290 300
DSFEKEVLVK GRDEEKKEEV QGRQKKDNIN KYKIINCTDI SHNNMNYVCD
310 320 330 340 350
NSKEPQVENL QKNKLINKFT VGSEEEEDND DINDAAKNNN TNYLRKTVSD
360 370 380 390 400
DGMKLKSNRN HNKKLGSRGR IHEITSSNKL NTNDPSRLHL PAWVFCTRYS
410 420 430 440 450
DRPSSGPRIR KPRMNRSNDE LNLKRPRTSF TVPQLKRLSQ EFEKNRYLDE
460 470 480 490 500
LRRKKLATEL DLRESQVKIW FQNKRAKTKK ASGAQNCLAL HLMAEGLYNH
510 520
SVRVRSDIEE DEEDSDDMNT SEKE
Length:524
Mass (Da):60,368
Last modified:November 1, 1996 - v1
Checksum:i63972F17DE0EC626
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M85305 mRNA. Translation: AAA29929.1.
PIRiS33640.

Genome annotation databases

GeneDBiSmp_145200.1:pep.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M85305 mRNA. Translation: AAA29929.1.
PIRiS33640.

3D structure databases

ProteinModelPortaliQ26601.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6183.Smp_145200__mRNA.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneDBiSmp_145200.1:pep.

Phylogenomic databases

eggNOGiKOG0493. Eukaryota.
ENOG4111P06. LUCA.
OrthoDBiEOG091G0XBB.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR019549. Homeobox-engrailed_C-terminal.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000747. Homeodomain_engrailed.
IPR019737. Homoebox-engrailed_CS.
[Graphical view]
PfamiPF10525. Engrail_1_C_sig. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00026. ENGRAILED.
PR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00033. ENGRAILED. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSMOX2_SCHMA
AccessioniPrimary (citable) accession number: Q26601
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: October 5, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.