Reviewed, UniProtKB/Swiss-Prot Q26534 (CATL_SCHMA)

Names and origin

Protein names

Recommended name:
    Cathepsin L
    EC=3.4.22.15
Alternative name(s):
    SMCL1

Gene names

Name:

CL1

Organism

Schistosoma mansoni (Blood fluke)

Taxonomic identifier

6183 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Platyhelminthes › Trematoda › Digenea › Strigeidida › Schistosomatoidea › Schistosomatidae › Schistosoma

Protein attributes

Sequence length	319 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	May be crucial for metabolism of host hemoglobin.
Catalytic activity	Specificity close to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity toward protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity.
Subcellular location	Lysosome.
Sequence similarities	Belongs to the peptidase C1 family.

Ontologies

Keywords
Cellular component	Lysosome
Domain	Signal
Molecular function	Hydrolase Protease Thiol protease
PTM	Disulfide bond Glycoprotein Zymogen
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: InterPro
Cellular component	lysosome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	cysteine-type endopeptidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – ?		Potential
	Propeptide	? – 104		Activation peptide Potential		PRO_0000026279
	Chain	105 – 319	215	Cathepsin L		PRO_0000026280
Sites
	Active site	129	1	By similarity
	Active site	265	1	By similarity
	Active site	286	1	By similarity
Amino acid modifications
	Glycosylation	212	1	N-linked (GlcNAc...) Potential
	Glycosylation	216	1	N-linked (GlcNAc...) Potential
	Glycosylation	231	1	N-linked (GlcNAc...) Potential
	Disulfide bond	126 ↔ 167		By similarity
	Disulfide bond	160 ↔ 200		By similarity
	Disulfide bond	258 ↔ 307		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q26534-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 9CFE68A3F1193479	FASTA	319	36,136
	10 20 30 40 50 60 MPVNLEYLGF KLPGNVDEKY VQFKLKYRKQ YHETEDEIRF NIFKSNILKA QLYQVFVRGS 70 80 90 100 110 120 AIYGVTPYSD LTTDEFARTH LTASWVVPSS RSNTPTSLGK EVNNIPKNFD WREKGAVTEV 130 140 150 160 170 180 KNQGMCGSCW AFSTTGNVES QWFRKTGKLL SLSEQQLVDC DGLDDGCNGG LPSNAYESII 190 200 210 220 230 240 KMGGLMLEDN YPYDAKNEKC HLKTDGVAVY INSSVNLTQD ETELAAWLYH NSTISVGMNA 250 260 270 280 290 300 LLLQFYQHGI SHPWWIFCSK YLLDHAVLLV GYGVSEKNEP FWIVKNSWGV EWGENGYFRM 310 YRGDGSCGIN TVATSAMIY

References

[1]	"Adult Schistosoma mansoni express cathepsin L proteinase activity." Smith A.M., Dalton J.P., Clough K.A., Kilbane C.L., Harrop S.A., Hole N., Brindley P.J. Mol. Biochem. Parasitol. 67:11-19(1994) [PubMed: 7838171] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Puerto Rican.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U07345 mRNA. Translation: AAC46485.1.
3D structure databases
HSSP	HSSP built from PDB template 1M6D based on UniProtKB Q9UBX1.
ModBase	Search...
Protein family/group databases
MEROPS	C01.018.
Enzyme and pathway databases
BRENDA	3.4.22.15. 1460.
Family and domain databases
InterPro	IPR000169. Pept_cys_AS. IPR013128. Peptidase_C1A. IPR000668. Peptidase_C1A_C. IPR013201. Prot_inhib_I29. [Graphical view]
PANTHER	PTHR12411. Peptidase_C1A. 1 hit.
Pfam	PF08246. Inhibitor_I29. 1 hit. PF00112. Peptidase_C1. 1 hit. [Graphical view]
PRINTS	PR00705. PAPAIN.
ProDom	PD000158. Peptidase_C1. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00645. Pept_C1. 1 hit. [Graphical view]
PROSITE	PS00640. THIOL_PROTEASE_ASN. 1 hit. PS00139. THIOL_PROTEASE_CYS. 1 hit. PS00639. THIOL_PROTEASE_HIS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CATL_SCHMA

Accession

Primary (citable) accession number: Q26534

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	November 1, 1996
Last modified:	June 16, 2009
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)