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Protein
Submitted name:

Aspartic proteinase

Gene

ctsd

Organism
Schistosoma japonicum (Blood fluke)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei84PROSITE-ProRule annotation1
Active sitei270PROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionAspartyl proteasePROSITE-ProRule annotation, Hydrolase, Protease

Protein family/group databases

MEROPSiA01.009.

Names & Taxonomyi

Protein namesi
Submitted name:
Aspartic proteinaseImported
Submitted name:
Cathepsin D (Lysosomal aspartyl protease)Imported (EC:3.4.23.5Imported)
Gene namesi
Name:ctsdImported
OrganismiSchistosoma japonicum (Blood fluke)Imported
Taxonomic identifieri6182 [NCBI]
Taxonomic lineageiEukaryotaMetazoaPlatyhelminthesTrematodaDigeneaStrigeididaSchistosomatoideaSchistosomatidaeSchistosoma

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Structurei

3D structure databases

ProteinModelPortaliQ26515.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini66 – 380Peptidase A1InterPro annotationAdd BLAST315

Sequence similaritiesi

Belongs to the peptidase A1 family.PROSITE-ProRule annotationSAAS annotation

Family and domain databases

Gene3Di2.40.70.10. 2 hits.
InterProiView protein in InterPro
IPR001461. Aspartic_peptidase_A1.
IPR001969. Aspartic_peptidase_AS.
IPR012848. Aspartic_peptidase_N.
IPR033144. Cathepsin_D.
IPR033121. PEPTIDASE_A1.
IPR021109. Peptidase_aspartic_dom.
PANTHERiPTHR13683. PTHR13683. 1 hit.
PTHR13683:SF487. PTHR13683:SF487. 1 hit.
PfamiView protein in Pfam
PF07966. A1_Propeptide. 1 hit.
PF00026. Asp. 1 hit.
PRINTSiPR00792. PEPSIN.
SUPFAMiSSF50630. SSF50630. 1 hit.
PROSITEiView protein in PROSITE
PS00141. ASP_PROTEASE. 2 hits.
PS51767. PEPTIDASE_A1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q26515-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLHLLLLLHL VSSEVVRVPL YPLKSARRSL IEFETSLENV QKVWFSRFSN
60 70 80 90 100
VEPRPEYLKN YLDAQYYGDI TIGTPPQTFS VVFDTGSSNL WVPSKHCSYF
110 120 130 140 150
DIACLLHRKY DSSKSTTYVP NGTDFSIRYG TGSLSGFLST DSLQLGSLGV
160 170 180 190 200
KGQTFGEATK QPGLVFVMAK FDGILGMAYP SLAVGGVTPV FVNMIKQGVV
210 220 230 240 250
DSPVFSFYLS RNITNVLGGE LMIGGIDDKY YTGEINYVNL TEKSYWLFKM
260 270 280 290 300
DNLTISDLSI CTDGCQAIAD TGTSMIAGPT DEVKQINQKL GATHLPGGIY
310 320 330 340 350
TVSCDVINNL PSIDFVINGK HMTLEPTDYI MKVSKLGSEI CLTGFIGMDL
360 370 380 390 400
PRKKLWILGD VFIGKFYTIF DMGKNRVGFA KAVKPDSSYH HTKVYSPMLR
410 420
LFPAQSIPKV APKSPNGVFA FSKLLHDAN
Length:429
Mass (Da):47,382
Last modified:January 1, 1998 - v2
Checksum:iD0CFD8B65C1F4FC4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L41346 mRNA. Translation: AAC37302.1.
FN316577 mRNA. Translation: CAX72308.1.
FN316578 mRNA. Translation: CAX72309.1.
FN316579 mRNA. Translation: CAX72310.1.
FN316580 mRNA. Translation: CAX72311.1.
FN316581 mRNA. Translation: CAX72312.1.
FN316582 mRNA. Translation: CAX72313.1.
FN316584 mRNA. Translation: CAX72315.1.
FN316586 mRNA. Translation: CAX72317.1.
FN316587 mRNA. Translation: CAX72318.1.
FN316592 mRNA. Translation: CAX72323.1.
FN316593 mRNA. Translation: CAX72324.1.
FN316595 mRNA. Translation: CAX72326.1.
FN316596 mRNA. Translation: CAX72327.1.
FN316597 mRNA. Translation: CAX72328.1.
FN316598 mRNA. Translation: CAX72329.1.
FN316602 mRNA. Translation: CAX72333.1.
FN316603 mRNA. Translation: CAX72334.1.
FN316605 mRNA. Translation: CAX72336.1.
FN316606 mRNA. Translation: CAX72337.1.
FN316607 mRNA. Translation: CAX72338.1.
FN316608 mRNA. Translation: CAX72339.1.
FN316611 mRNA. Translation: CAX72342.1.
FN323678 mRNA. Translation: CAX79402.1.

Similar proteinsi

Entry informationi

Entry nameiQ26515_SCHJA
AccessioniPrimary (citable) accession number: Q26515
Secondary accession number(s): O02027
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: January 1, 1998
Last modified: May 10, 2017
This is version 84 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation