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Protein

Pilosulin-3a

Gene
N/A
Organism
Myrmecia pilosula (Jack jumper ant) (Australian jumper ant)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Has no hemolytic activity.

Names & Taxonomyi

Protein namesi
Recommended name:
Pilosulin-3a
Alternative name(s):
Allergen Myr p II
Pilosulin-2
Allergen: Myr p 2
OrganismiMyrmecia pilosula (Jack jumper ant) (Australian jumper ant)
Taxonomic identifieri13618 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaHymenopteraApocritaAculeataVespoideaFormicidaeMyrmeciinaeMyrmeciiniMyrmecia

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human. Binds to IgE.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei3381. Myr p 2.0101.
3575. Myr p 2.0102.
481. Myr p 2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence analysisAdd
BLAST
Propeptidei27 – 48221 PublicationPRO_0000035164Add
BLAST
Peptidei49 – 7426Pilosulin-3aPRO_0000035165Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi64 – 64Interchain (with C-17 in pilosulin 3b)
Disulfide bondi71 – 71Interchain (with C-10 in pilosulin 3b)
Modified residuei74 – 741Leucine amide1 Publication

Keywords - PTMi

Amidation, Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Interactioni

Subunit structurei

Heterodimer with pilosin-3b (AC P0C023); disulfide-linked. This heterodimer is named pilosulin-3.2 Publications

Family & Domainsi

Sequence similaritiesi

Belongs to the pilosulin family.Curated

Keywords - Domaini

Signal

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q26464-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLSCLLLTL AIIFVLTIVH APNVEAKALA DPESDAVGFA DAVGEADPID
60 70
WKKVDWKKVS KKTCKVMLKA CKFLG
Length:75
Mass (Da):8,145
Last modified:November 1, 1997 - v1
Checksum:i4FFE49969405F7AC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S81785 mRNA. Translation: AAB36316.1.
PIRiS65711.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S81785 mRNA. Translation: AAB36316.1.
PIRiS65711.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei3381. Myr p 2.0101.
3575. Myr p 2.0102.
481. Myr p 2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning and characterization of the major allergen Myr p II from the venom of the jumper ant Myrmecia pilosula: Myr p I and Myr p II share a common protein leader sequence."
    Street M.D., Donovan G.R., Baldo B.A.
    Biochim. Biophys. Acta 1305:87-97(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 49-54.
    Tissue: Venom gland.
  2. "Expression of jumper ant (Myrmecia pilosula) venom allergens: post-translational processing of allergen gene products."
    Donovan G.R., Street M.D., Tetaz T., Smith A.I., Alewood D., Alewood P.F., Sutherland S.K., Baldo B.A.
    Biochem. Mol. Biol. Int. 39:877-885(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL PROTEIN SEQUENCE, SUBUNIT.
    Tissue: Venom.
  3. "Characterisation of major peptides in 'jack jumper' ant venom by mass spectrometry."
    Davies N.W., Wiese M.D., Brown S.G.A.
    Toxicon 43:173-183(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: AMIDATION AT LEU-74, SUBUNIT, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Venom.

Entry informationi

Entry nameiMYR3A_MYRPI
AccessioniPrimary (citable) accession number: Q26464
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: January 7, 2015
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.