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Q26457 (LA_AEDAL) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
La protein homolog
Alternative name(s):
La autoantigen homolog
La ribonucleoprotein
OrganismAedes albopictus (Asian tiger mosquito) (Stegomyia albopicta)
Taxonomic identifier7160 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraCulicoideaCulicidaeCulicinaeAediniAedesStegomyia

Protein attributes

Sequence length383 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May be involved in transcription termination by RNA polymerase III. Binds RNA and DNA. Binds to the 3' end of the minus strand of Sindbis virus RNA. This may be significant for Sindbis virus RNA replication.

Subcellular location

Nucleus. Cytoplasm. Note: Primarily nuclear, but significant amounts are present in the cytoplasm.

Sequence similarities

Contains 1 HTH La-type RNA-binding domain.

Contains 1 RRM (RNA recognition motif) domain.

Ontologies

Keywords
   Cellular componentCytoplasm
Nucleus
   LigandDNA-binding
RNA-binding
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Biological_processRNA processing

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

ribonucleoprotein complex

Inferred from electronic annotation. Source: InterPro

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

RNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

nucleotide binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 383383La protein homolog
PRO_0000207605

Regions

Domain37 – 12993HTH La-type RNA-binding
Domain141 – 22888RRM

Sequences

Sequence LengthMass (Da)Tools
Q26457 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 4E5CC8F21C40F452

FASTA38344,430
        10         20         30         40         50         60 
MTEVEAKATA TEETTKEEEE APETTAEQTE ESAQETSENV SKLEASTIRQ LEYYFGDANL 

        70         80         90        100        110        120 
ARDKFLQEQI SKDEGWVPVD VLLTFKRLKS LSEDKKVIVD AIEKSDEGLI EVSEDREKLR 

       130        140        150        160        170        180 
RHPERPLPEQ NEETRKEIYG RTVYVKGFAP EEGTQMSELL EFFEPFEKIT NIVMRKYHDK 

       190        200        210        220        230        240 
ATKKYLFKGS VFVTFATKDH CAEFLKKEKL GYKGKELIRK MQDDYFEEKK AERRKKDKKK 

       250        260        270        280        290        300 
EEDRFNIDHL PKGASVHLSG FNKDTSRETI KETILKLDES LEVAFIDYAK TDTEGTVRFA 

       310        320        330        340        350        360 
ADDAGKKFME KLTDSKIQID EEEITARLLE GDEEKEFLRK VVKDQQARRQ ASNARNKGRT 

       370        380 
PEGRQASRPP QEWRRKAKGG RGE 

« Hide

References

[1]"Mosquito homolog of the La autoantigen binds to Sindbis virus RNA."
Pardigon N., Strauss J.H.
J. Virol. 70:1173-1181(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
S80954 mRNA. Translation: AAB35931.1.

3D structure databases

ProteinModelPortalQ26457.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.10.10.10. 1 hit.
3.30.70.330. 2 hits.
InterProIPR002344. Lupus_La.
IPR006630. Lupus_La_RNA-bd.
IPR012677. Nucleotide-bd_a/b_plait.
IPR014886. RRM_3.
IPR000504. RRM_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF05383. La. 1 hit.
PF08777. RRM_3. 1 hit.
[Graphical view]
PRINTSPR00302. LUPUSLA.
SMARTSM00715. LA. 1 hit.
SM00360. RRM. 1 hit.
[Graphical view]
PROSITEPS50961. HTH_LA. 1 hit.
PS50102. RRM. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameLA_AEDAL
AccessionPrimary (citable) accession number: Q26457
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: May 1, 2013
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families