Q26457 (LA_AEDAL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: La protein homolog Alternative name(s): La autoantigen homolog La ribonucleoprotein
Organism	Aedes albopictus (Asian tiger mosquito) (Stegomyia albopicta)
Taxonomic identifier	7160 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Endopterygota › Diptera › Nematocera › Culicimorpha › Culicoidea › Culicidae › Culicinae › Aedini › Aedes › Stegomyia

Protein attributes

Sequence length	383 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be involved in transcription termination by RNA polymerase III. Binds RNA and DNA. Binds to the 3' end of the minus strand of Sindbis virus RNA. This may be significant for Sindbis virus RNA replication.
Subcellular location	Nucleus. Cytoplasm. Note: Primarily nuclear, but significant amounts are present in the cytoplasm.
Sequence similarities	Contains 1 HTH La-type RNA-binding domain. Contains 1 RRM (RNA recognition motif) domain.

Ontologies

Keywords
Cellular component	Cytoplasm Nucleus
Ligand	DNA-binding RNA-binding
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological_process	RNA processing Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell ribonucleoprotein complex Inferred from electronic annotation. Source: InterPro
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW RNA binding Inferred from electronic annotation. Source: UniProtKB-KW nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 383	383	La protein homolog		PRO_0000207605
Regions
	Domain	37 – 129	93	HTH La-type RNA-binding
	Domain	141 – 228	88	RRM

Sequences

	Sequence		Length	Mass (Da)
	Q26457 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 4E5CC8F21C40F452	FASTA	383	44,430
	10 20 30 40 50 60 MTEVEAKATA TEETTKEEEE APETTAEQTE ESAQETSENV SKLEASTIRQ LEYYFGDANL 70 80 90 100 110 120 ARDKFLQEQI SKDEGWVPVD VLLTFKRLKS LSEDKKVIVD AIEKSDEGLI EVSEDREKLR 130 140 150 160 170 180 RHPERPLPEQ NEETRKEIYG RTVYVKGFAP EEGTQMSELL EFFEPFEKIT NIVMRKYHDK 190 200 210 220 230 240 ATKKYLFKGS VFVTFATKDH CAEFLKKEKL GYKGKELIRK MQDDYFEEKK AERRKKDKKK 250 260 270 280 290 300 EEDRFNIDHL PKGASVHLSG FNKDTSRETI KETILKLDES LEVAFIDYAK TDTEGTVRFA 310 320 330 340 350 360 ADDAGKKFME KLTDSKIQID EEEITARLLE GDEEKEFLRK VVKDQQARRQ ASNARNKGRT 370 380 PEGRQASRPP QEWRRKAKGG RGE

References

[1]	"Mosquito homolog of the La autoantigen binds to Sindbis virus RNA." Pardigon N., Strauss J.H. J. Virol. 70:1173-1181(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.

Cross-references

Sequence databases
EMBL GenBank DDBJ	S80954 mRNA. Translation: AAB35931.1.
3D structure databases
ProteinModelPortal	Q26457.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	1.10.10.10. 1 hit. 3.30.70.330. 2 hits.
InterPro	IPR002344. Lupus_La. IPR006630. Lupus_La_RNA-bd. IPR012677. Nucleotide-bd_a/b_plait. IPR014886. RRM_3. IPR000504. RRM_dom. IPR011991. WHTH_DNA-bd_dom. [Graphical view]
Pfam	PF05383. La. 1 hit. PF08777. RRM_3. 1 hit. [Graphical view]
PRINTS	PR00302. LUPUSLA.
SMART	SM00715. LA. 1 hit. SM00360. RRM. 1 hit. [Graphical view]
PROSITE	PS50961. HTH_LA. 1 hit. PS50102. RRM. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LA_AEDAL

Accession

Primary (citable) accession number: Q26457

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	November 1, 1996
Last modified:	May 1, 2013
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)