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Q26457

- LA_AEDAL

UniProt

Q26457 - LA_AEDAL

Protein

La protein homolog

Gene
N/A
Organism
Aedes albopictus (Asian tiger mosquito) (Stegomyia albopicta)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    • Comment

    Functioni

    May be involved in transcription termination by RNA polymerase III. Binds RNA and DNA. Binds to the 3' end of the minus strand of Sindbis virus RNA. This may be significant for Sindbis virus RNA replication.

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. nucleotide binding Source: InterPro
    3. RNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. RNA processing Source: InterPro

    Keywords - Ligandi

    DNA-binding, RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    La protein homolog
    Alternative name(s):
    La autoantigen homolog
    La ribonucleoprotein
    OrganismiAedes albopictus (Asian tiger mosquito) (Stegomyia albopicta)
    Taxonomic identifieri7160 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraCulicoideaCulicidaeCulicinaeAediniAedesStegomyia

    Subcellular locationi

    Nucleus. Cytoplasm
    Note: Primarily nuclear, but significant amounts are present in the cytoplasm.

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell
    3. ribonucleoprotein complex Source: InterPro

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 383383La protein homologPRO_0000207605Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ26457.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini37 – 12993HTH La-type RNA-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini141 – 22888RRMPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 HTH La-type RNA-binding domain.PROSITE-ProRule annotation
    Contains 1 RRM (RNA recognition motif) domain.PROSITE-ProRule annotation

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    3.30.70.330. 2 hits.
    InterProiIPR002344. Lupus_La.
    IPR006630. Lupus_La_RNA-bd.
    IPR012677. Nucleotide-bd_a/b_plait.
    IPR014886. RRM_3.
    IPR000504. RRM_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF05383. La. 1 hit.
    PF08777. RRM_3. 1 hit.
    [Graphical view]
    PRINTSiPR00302. LUPUSLA.
    SMARTiSM00715. LA. 1 hit.
    SM00360. RRM. 1 hit.
    [Graphical view]
    PROSITEiPS50961. HTH_LA. 1 hit.
    PS50102. RRM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q26457-1 [UniParc]FASTAAdd to Basket

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    MTEVEAKATA TEETTKEEEE APETTAEQTE ESAQETSENV SKLEASTIRQ    50
    LEYYFGDANL ARDKFLQEQI SKDEGWVPVD VLLTFKRLKS LSEDKKVIVD 100
    AIEKSDEGLI EVSEDREKLR RHPERPLPEQ NEETRKEIYG RTVYVKGFAP 150
    EEGTQMSELL EFFEPFEKIT NIVMRKYHDK ATKKYLFKGS VFVTFATKDH 200
    CAEFLKKEKL GYKGKELIRK MQDDYFEEKK AERRKKDKKK EEDRFNIDHL 250
    PKGASVHLSG FNKDTSRETI KETILKLDES LEVAFIDYAK TDTEGTVRFA 300
    ADDAGKKFME KLTDSKIQID EEEITARLLE GDEEKEFLRK VVKDQQARRQ 350
    ASNARNKGRT PEGRQASRPP QEWRRKAKGG RGE 383
    Length:383
    Mass (Da):44,430
    Last modified:November 1, 1996 - v1
    Checksum:i4E5CC8F21C40F452
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S80954 mRNA. Translation: AAB35931.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S80954 mRNA. Translation: AAB35931.1 .

    3D structure databases

    ProteinModelPortali Q26457.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    3.30.70.330. 2 hits.
    InterProi IPR002344. Lupus_La.
    IPR006630. Lupus_La_RNA-bd.
    IPR012677. Nucleotide-bd_a/b_plait.
    IPR014886. RRM_3.
    IPR000504. RRM_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF05383. La. 1 hit.
    PF08777. RRM_3. 1 hit.
    [Graphical view ]
    PRINTSi PR00302. LUPUSLA.
    SMARTi SM00715. LA. 1 hit.
    SM00360. RRM. 1 hit.
    [Graphical view ]
    PROSITEi PS50961. HTH_LA. 1 hit.
    PS50102. RRM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mosquito homolog of the La autoantigen binds to Sindbis virus RNA."
      Pardigon N., Strauss J.H.
      J. Virol. 70:1173-1181(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.

    Entry informationi

    Entry nameiLA_AEDAL
    AccessioniPrimary (citable) accession number: Q26457
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3