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Protein

Mite allergen Der f 7

Gene

DERF7

Organism
Dermatophagoides farinae (American house dust mite)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Mite allergen Der f 7
Alternative name(s):
Allergen Der f VII
Allergen: Der f 7
Gene namesi
Name:DERF7
OrganismiDermatophagoides farinae (American house dust mite)
Taxonomic identifieri6954 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAcariAcariformesSarcoptiformesAstigmataPsoroptidiaAnalgoideaPyroglyphidaeDermatophagoidinaeDermatophagoides

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human. Common symptoms of mite allergy are bronchial asthma, allergic rhinitis and conjunctivitis.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei307. Der f 7.
3256. Der f 7.0101.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000000118418 – 213Mite allergen Der f 7Add BLAST196

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi151N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ26456.

Structurei

Secondary structure

1213
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi24 – 41Combined sources18
Beta strandi43 – 51Combined sources9
Beta strandi54 – 61Combined sources8
Beta strandi63 – 79Combined sources17
Helixi81 – 83Combined sources3
Beta strandi84 – 89Combined sources6
Beta strandi91 – 95Combined sources5
Beta strandi98 – 110Combined sources13
Beta strandi112 – 122Combined sources11
Beta strandi128 – 136Combined sources9
Beta strandi139 – 150Combined sources12
Beta strandi153 – 159Combined sources7
Beta strandi163 – 169Combined sources7
Helixi177 – 211Combined sources35

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3UV1X-ray2.00A/B18-213[»]
ProteinModelPortaliQ26456.
SMRiQ26456.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the mite group 7 allergen family.Curated

Keywords - Domaini

Signal

Family and domain databases

InterProiIPR020234. Mite_allergen_group-7.
[Graphical view]
PfamiPF16984. Grp7_allergen. 1 hit.
[Graphical view]
ProDomiPD037435. Mite_group-7_allergen. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q26456-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMKFLLIAAV AFVAVSADPI HYDKITEEIN KAIDDAIAAI EQSETIDPMK
60 70 80 90 100
VPDHADKFER HVGIVDFKGE LAMRNIEARG LKQMKRQGDA NVKGEEGIVK
110 120 130 140 150
AHLLIGVHDD IVSMEYDLAY KLGDLHPTTH VISDIQDFVV ALSLEISDEG
160 170 180 190 200
NITMTSFEVR QFANVVNHIG GLSILDPIFG VLSDVLTAIF QDTVRKEMTK
210
VLAPAFKREL EKN
Length:213
Mass (Da):23,627
Last modified:November 1, 1997 - v1
Checksum:i3CF1F529107B7808
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S80655 mRNA. Translation: AAB35977.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S80655 mRNA. Translation: AAB35977.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3UV1X-ray2.00A/B18-213[»]
ProteinModelPortaliQ26456.
SMRiQ26456.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei307. Der f 7.
3256. Der f 7.0101.

Proteomic databases

PRIDEiQ26456.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR020234. Mite_allergen_group-7.
[Graphical view]
PfamiPF16984. Grp7_allergen. 1 hit.
[Graphical view]
ProDomiPD037435. Mite_group-7_allergen. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Entry informationi

Entry nameiALL7_DERFA
AccessioniPrimary (citable) accession number: Q26456
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 2, 2016
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.