Q26456 (ALL7_DERFA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mite allergen Der f 7

Alternative name(s):
Allergen Der f VII
Allergen=Der f 7

Gene names

Name:

DERF7

Organism

Dermatophagoides farinae (American house dust mite)

Taxonomic identifier

6954 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Chelicerata › Arachnida › Acari › Acariformes › Sarcoptiformes › Astigmata › Psoroptidia › Analgoidea › Pyroglyphidae › Dermatophagoidinae › Dermatophagoides

Protein attributes

Sequence length	213 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Secreted.
Allergenic properties	Causes an allergic reaction in human. Common symptoms of mite allergy are bronchial asthma, allergic rhinitis and conjunctivitis.
Sequence similarities	Belongs to the mite group 7 allergen family.

Ontologies

Keywords
Cellular component	Secreted
Disease	Allergen
Domain	Signal
PTM	Glycoprotein
Technical term	3D-structure
Gene Ontology (GO)
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 17

17

Potential

Chain

18 – 213

196

Mite allergen Der f 7

PRO_0000001184

Amino acid modifications

Glycosylation

151

1

N-linked (GlcNAc...) Potential

Secondary structure

1

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213

Helix Strand Turn

Details...

Helix

24 – 41

18

Beta strand

43 – 51

9

Beta strand

54 – 61

8

Beta strand

63 – 79

17

Helix

81 – 83

3

Beta strand

84 – 89

6

Beta strand

91 – 95

5

Beta strand

98 – 110

13

Beta strand

112 – 122

11

Beta strand

128 – 136

9

Beta strand

139 – 150

12

Beta strand

153 – 159

7

Beta strand

163 – 169

7

Helix

177 – 211

35

Sequences

	Sequence		Length	Mass (Da)
	Q26456 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: 3CF1F529107B7808	FASTA	213	23,627
	10 20 30 40 50 60 MMKFLLIAAV AFVAVSADPI HYDKITEEIN KAIDDAIAAI EQSETIDPMK VPDHADKFER 70 80 90 100 110 120 HVGIVDFKGE LAMRNIEARG LKQMKRQGDA NVKGEEGIVK AHLLIGVHDD IVSMEYDLAY 130 140 150 160 170 180 KLGDLHPTTH VISDIQDFVV ALSLEISDEG NITMTSFEVR QFANVVNHIG GLSILDPIFG 190 200 210 VLSDVLTAIF QDTVRKEMTK VLAPAFKREL EKN

References

[1]	"Molecular cloning and immunological characterization of the house dust mite allergen Der f 7." Shen H.-D., Chua K.-Y., Lin W.L., Hsieh K.-H., Thomas W.R. Clin. Exp. Allergy 25:1000-1006(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

S80655 mRNA. Translation: AAB35977.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3UV1	X-ray	2.00	A/B	18-213	[»]

ProteinModelPortal

Q26456.

ModBase

Search...

Protein family/group databases

Allergome

307. Der f 7.
3256. Der f 7.0101.

Proteomic databases

PRIDE

Q26456.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Family and domain databases

InterPro

IPR020234. Mite_allergen_group-7.
[Graphical view]

ProDom

PD037435. Mite_group-7_allergen. 1 hit.
[Graphical view] [Entries sharing at least one domain]

ProtoNet

Search...

Entry information

Entry name

ALL7_DERFA

Accession

Primary (citable) accession number: Q26456

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	April 3, 2013
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)