Reviewed, UniProtKB/Swiss-Prot Q26416 (CUA1_DROME)

Names and origin

Protein names

Recommended name:
    Adult cuticle protein 1
Alternative name(s):
    dACP-1

Gene names

Name:	Acp1
ORF Names:	CG7216

Organism

Drosophila melanogaster (Fruit fly) [Complete proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	135 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Component of the cuticle of the adult fruit fly. Could be involved in thickening of the hard adult cuticle. Ref.1
Tissue specificity	Detected in the epidermis underlying the head and thorax (including legs and wings), but not in the abdominal epidermis of newly eclosed flies. Ref.1
Developmental stage	Expression starts around 72 hours after pupariation, peaks 12 hours after eclosion and decreases thereafter to undetectable levels by 3 days after eclosion. Ref.1
Domain	The tetrapeptide (A-A-P-[AV]) repeats found throughout the protein are also present in many proteins constituting the protective envelope of other species.

Ontologies

Keywords
Cellular component	Cuticle
Domain	Repeat Signal
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	structural constituent of cuticle Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Potential
	Chain	20 – 135	116	Adult cuticle protein 1		PRO_0000006402
Regions
	Repeat	72 – 75	4	1
	Repeat	78 – 81	4	2
	Repeat	128 – 131	4	3

Sequences

	Sequence		Length	Mass (Da)
	Q26416-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 76A322083ADC362D	FASTA	135	13,119
	10 20 30 40 50 60 MKFAVAVIFT LALAMGVQSS VIPLLSQVAG HGLSYTAVSG PAVVASPWAV PAAHWPAAVN 70 80 90 100 110 120 VASWPPAAIH AAAPAVLAAP APAVVAAHAP SVVVAPVAHS GVYTAQTRGA IHTAPLAGHI 130 QSVASINAAP APGTL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Temporal and spatial expression of an adult cuticle protein gene from Drosophila suggests that its protein product may impart some specialized cuticle function." Qiu J., Hardin P.E. Dev. Biol. 167:416-425(1995) [PubMed: 7875368] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE. Strain: Canton-S. Tissue: Head.
[2]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[3]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: GENOME REANNOTATION.
[4]	"A Drosophila full-length cDNA resource." Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E. Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed: 12537569] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Berkeley. Tissue: Head.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	S76894 Genomic DNA. Translation: AAB33567.2. AE014134 Genomic DNA. Translation: AAF52547.1. AY119158 mRNA. Translation: AAM51018.1.
RefSeq	NP_477115.1.
UniGene	Dm.19793
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q26416. 1 interaction.
Genome annotation databases
Ensembl	FBtr0079500; FBpp0079123; FBgn0014454; Drosophila melanogaster. [Genome view]
GeneID	34052.
KEGG	dme:Dmel_CG7216.
NMPDR	fig|7227.3.peg.1290.
Organism-specific databases
CTD	34052.
FlyBase	FBgn0014454. Acp1.
Phylogenomic databases
HOGENOM	Q26416.
OMA	PLAGHIQ
OrthoDB	EOG9VHKCZ
Enzyme and pathway databases
BioCyc	DMEL-XXX-02:DMEL-XXX-02-007877-MON.
Gene expression databases
GermOnline	CG7216. Drosophila melanogaster.
Family and domain databases
ProtoNet	Search...
Other Resources
NextBio	786629.

Entry information

Entry name

CUA1_DROME

Accession

Primary (citable) accession number: Q26416
Secondary accession number(s): Q9VLY2

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	November 1, 1996
Last modified:	November 24, 2009
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Drosophila annotation project