Reviewed, UniProtKB/Swiss-Prot Q26307 (ANA_DROME)

Names and origin

Protein names

Recommended name:
    Protein anachronism

Gene names

Name:	ana
ORF Names:	CG8084

Organism

Drosophila melanogaster (Fruit fly) [Complete proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	474 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Negatively regulates proliferation of neuronal precursor cells, thereby controlling the timing of postembryonic neurogenesis.
Subcellular location	Secreted.
Tissue specificity	Synthesized in some glial cells and secreted.

Ontologies

Keywords
Biological process	Differentiation Neurogenesis
Cellular component	Secreted
Domain	Signal
Molecular function	Developmental protein
PTM	Glycoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell differentiation Inferred from electronic annotation. Source: UniProtKB-KW nervous system development Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
CG14487	Q9V876	1	EBI-145644,EBI-136574

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 33	33	Potential
	Chain	34 – 474	441	Protein anachronism		PRO_0000020730
Regions
	Compositional bias	453 – 462	10	Poly-His
Amino acid modifications
	Glycosylation	54	1	N-linked (GlcNAc...) Potential
	Glycosylation	62	1	N-linked (GlcNAc...) Potential
	Glycosylation	73	1	N-linked (GlcNAc...) Potential
	Glycosylation	116	1	N-linked (GlcNAc...) Potential
	Glycosylation	144	1	N-linked (GlcNAc...) Potential
	Glycosylation	342	1	N-linked (GlcNAc...) Potential
Experimental info
	Sequence conflict	388	1	A → G in AAB27582. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q26307-1 [UniParc]. Last modified December 1, 2000. Version 2. Checksum: FE8A43042BB595A1	FASTA	474	54,015
	10 20 30 40 50 60 MASAMRGEKC ERSRIRELVL ILSLITMAGD SRATPFDPSF FIEGVQSEVV NPFNRTILNR 70 80 90 100 110 120 FNLTEEQILS IQNRSNPNMR DDSAQSSNQQ YLQQVATQRL NDIFKRVQKA ISNEPNGSAS 130 140 150 160 170 180 KEKAGFPICN AETTNPEDWS LGNNVTLQFA SSVFISNNDD RLSSALLRLY KTNPGQTREH 190 200 210 220 230 240 NPGQASTQPI STENPGNTAP NCAEQPPVGP QIRVTVSIVH QQRKKQRKKR TCNTAMLSSS 250 260 270 280 290 300 STGWVEIDVK CALAYWEQQH RQQLRQQQPL QPQLTASVVG ILMIEVHDDE ENLLRPGLYF 310 320 330 340 350 360 APPTCDQADI AVPWSVYRTE PFKSHLASWT LPRKPRLDIF FNGSNSMKNS YNTPKSRAFI 370 380 390 400 410 420 ESTTSNSPTI DNQLDESGEY ESQQRVHAPL VHHRRHHHNH QQPESESESA QLEAEIEAEE 430 440 450 460 470 LMSSASNSEQ QMEPISNHHR HRTGHHHPHH QLHQHHHHHH RHTKHHRIPA HKQE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The Drosophila anachronism locus: a glycoprotein secreted by glia inhibits neuroblast proliferation." Ebens A.J., Garren H., Cheyette B.N.R., Zipursky S.L. Cell 74:15-27(1993) [PubMed: 7916657] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Eye imaginal disk.
[2]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[3]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: GENOME REANNOTATION.

Cross-references

Sequence databases
EMBLGenBankDDBJ	S63815 mRNA. Translation: AAB27582.1. AE013599 Genomic DNA. Translation: AAF58998.1.
RefSeq	NP_477038.1.
UniGene	Dm.7490
3D structure databases
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:21780N.
IntAct	Q26307. 1 interaction.
Genome annotation databases
Ensembl	FBgn0011746. Drosophila melanogaster. [Contig view]
GeneID	35913.
KEGG	dme:Dmel_CG8084.
NMPDR	fig|7227.3.peg.3990.
Organism-specific databases
FlyBase	FBgn0011746. ana.
Phylogenomic databases
HOGENOM	Q26307.
OMA	Q26307. KCALAYW.
Enzyme and pathway databases
BioCyc	DMEL-XXX-02:DMEL-XXX-02-003547-MON.
Gene expression databases
ArrayExpress	Q26307.
GermOnline	CG8084. Drosophila melanogaster.
Family and domain databases
ProtoNet	Search...
Other Resources
NextBio	795791.

Entry information

Entry name

ANA_DROME

Accession

Primary (citable) accession number: Q26307
Secondary accession number(s): Q9V524

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	December 1, 2000
Last modified:	June 16, 2009
This is version 69 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Drosophila annotation project