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Protein
Submitted name:

Myosin heavy chain

Gene
N/A
Organism
Placopecten magellanicus (Sea scallop)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Motor protein, MyosinSAAS annotation

Keywords - Ligandi

Actin-bindingSAAS annotation, ATP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Myosin heavy chainImported
OrganismiPlacopecten magellanicus (Sea scallop)Imported
Taxonomic identifieri6577 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaBivalviaPteriomorphiaPectinoidaPectinoideaPectinidaePlacopecten

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiQ26079.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2EC6X-ray3.25A1-838[»]
ProteinModelPortaliQ26079.
SMRiQ26079. Positions 1-924.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ26079.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini83 – 778696Myosin motorInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili842 – 89049Sequence analysisAdd
BLAST
Coiled coili905 – 1156252Sequence analysisAdd
BLAST
Coiled coili1164 – 124178Sequence analysisAdd
BLAST
Coiled coili1249 – 1374126Sequence analysisAdd
BLAST
Coiled coili1383 – 144563Sequence analysisAdd
BLAST
Coiled coili1453 – 148028Sequence analysisAdd
BLAST
Coiled coili1488 – 151528Sequence analysisAdd
BLAST
Coiled coili1523 – 159674Sequence analysisAdd
BLAST
Coiled coili1608 – 1803196Sequence analysisAdd
BLAST
Coiled coili1805 – 1923119Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.SAAS annotation
Contains IQ domain.SAAS annotation
Contains myosin motor domain.SAAS annotation

Keywords - Domaini

Coiled coilSequence analysisSAAS annotation

Family and domain databases

Gene3Di4.10.270.10. 1 hit.
InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR027401. Myosin-like_IQ_dom.
IPR001609. Myosin_head_motor_dom.
IPR004009. Myosin_N.
IPR002928. Myosin_tail.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00063. Myosin_head. 1 hit.
PF02736. Myosin_N. 1 hit.
PF01576. Myosin_tail_1. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00015. IQ. 1 hit.
SM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50096. IQ. 1 hit.
PS51456. MYOSIN_MOTOR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q26079-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNIDFNDPDF QYLAVDRKKM MKEQTAPFDG KKNCWVPDPK EGFASAEIQS
60 70 80 90 100
SKGEEITVKI VSDNSTRTVK KDDIQQMNPP KFEKLEDMAN MTYLNEASVL
110 120 130 140 150
NNLRGRYTAG LIYTYSGLFC IAVNPYRRLP IYTDSVIAKY RGKRKTEIPP
160 170 180 190 200
HLFSVADNAY QNMVTDRENQ SCLITGESGA GKTENTKKVI MYLAKVACAV
210 220 230 240 250
KKKTSEEEEA DQKKGSLEDQ IIQANPVLEA YGNAKTTRNN NSSRFGKFIR
260 270 280 290 300
IHFGPTGKIA GADIETYLLE KSRVTYQQSA ERNYHIFYQI CSNAIPELNE
310 320 330 340 350
VMLITPDSGL YSFINQGCLT VDNIDDVEEF KLCDEAFDIL GFTKEEKTSM
360 370 380 390 400
FKCTASILHM GEMKFKQRPR EEQAESDGTA EAEKVAFLCG INAGDLLKAL
410 420 430 440 450
LKPKVKVGTE MVTKGQNLQQ VINSVGALSK SLYDRMFNWL VKRVNRTLDT
460 470 480 490 500
KAKRNYYIGV LDIAGFEIFD FNSFEQLCIN YTNERLQQFF NHHMFVLEQE
510 520 530 540 550
EYKKEGIQWE FIDFGMDLQM CIDLIEKPMG ILSILEEECM FPKADDKSFQ
560 570 580 590 600
DYSYQNHIGK NRMFTKPGKP TRPNQGHAHF ELHHYAGNVP YSIAGWLDKN
610 620 630 640 650
KDPINENVVS LLAVSKEPLV AELFRAPDEP AGGAGGKKKK KSSAFQTISA
660 670 680 690 700
VHRESLNKLM KNLYSTHPHF VRCIIPNELK QPGLVDAELV LHQLQCNGVL
710 720 730 740 750
EGIRICRKGF PSRLIYSEFK QRYSILAPNA IPQGFVDGKT VSEKILTGLQ
760 770 780 790 800
MDPSEYRLGT TKVFFKAGVL GNLEEMRDER LSKIISMFQA HIRGYLIRKA
810 820 830 840 850
YKKLQDQRIG LSVIQRNIRK WLVLRNWQWW KLYAKVKPLL SIARLEEEMK
860 870 880 890 900
EQVEQMDKMK EDLAKTERIK KELEEQNVTL LEQKNDLFLQ LQTIEDSMGD
910 920 930 940 950
QEDRVEKLIM QKADFESQIK ELEERLLDEE DAASDLEGIK KKMEGDNANL
960 970 980 990 1000
KKDIGELEHS LQKSEQEKAH KDNQISTLQG EMSQQDEHIG KLNKEKKALE
1010 1020 1030 1040 1050
EANKKTSDSL QAEEDKCNHL NKLKAKLEQA LDELEDNLER EKKVRGDVEK
1060 1070 1080 1090 1100
AKSKVEQDLK STQENVEDLE RVKRELEENV RRKEAEITTL NSKLEDEQNL
1110 1120 1130 1140 1150
VSQLQRKIKE LQARIEELEE ELEAERNARS KVEKQRAELN RELEELGERL
1160 1170 1180 1190 1200
DEAGGATSAQ IELNKKREAE LLKIRRDLEE ASLQHEAQIS AIRKKHQDAA
1210 1220 1230 1240 1250
NEMADQVDQL QKVKSKLEKD KKDLKREMDD LESQMTHDMK NKGCSEKVMK
1260 1270 1280 1290 1300
QFESQVSDLN ARLEDSQRSI NELQSQKSRL QAENSDLSRQ LEDAEHRVSV
1310 1320 1330 1340 1350
LSKEKSQLTS QLEDARRSLE DETRARTKLQ NEIRNMHADM DAAREQLEEE
1360 1370 1380 1390 1400
QESKSDVQRQ LSKANNEIQQ WRSKFESEGA NRTEELEDQK RKILGKLSEA
1410 1420 1430 1440 1450
EQNMEAANAK ASALDKAKSR LQQELEDLSI EVDRANANVN QMEKKQRAFD
1460 1470 1480 1490 1500
KTTSEWQSKV NSLQSELENS QKESRGYSAE LYRIKASVEE YQDSIGSLRR
1510 1520 1530 1540 1550
ENKNLADEIH DLTDQLSEGG RSSHELDKAR RRLEMEKEEL QAALEEAEGA
1560 1570 1580 1590 1600
LEQEEAKVMR AQLEIATVRN EIDKRIQEKE EEFDNTRRNH QRALESMQAS
1610 1620 1630 1640 1650
LEAEAKGKAD ALRIKKKLEQ DINELEVALD ASNRGKAEME KTVKRYQQQI
1660 1670 1680 1690 1700
REMQTSIEEE QRQRDEARES YNMAERRCTL MSGEVEELRA ALEQAERARK
1710 1720 1730 1740 1750
GSENELADAN DRVNELTSQV SSVQGQKRKL EGDINAMQTD LDEMHGELKG
1760 1770 1780 1790 1800
ADERCKKAMA DAARLADELR AEQDHSNQVE KVRKNLESQV KEFQIRLDEA
1810 1820 1830 1840 1850
EASSLKGGKK LIQKLESRVH ELEAELDNEQ RRHAETQKNM RKADRRLKEL
1860 1870 1880 1890 1900
AFQADEDRKN QERLQELIDK LNAKIKTFKR QVEEAEEIAA INLAKYRKAQ
1910 1920 1930 1940
HELEEAEERA DTADSSLQKF RAKSRSSVSV QRSSVSVSAA N
Length:1,941
Mass (Da):223,244
Last modified:November 1, 1996 - v1
Checksum:iE2AD1637FFDB8127
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U59294 mRNA. Translation: AAB03660.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U59294 mRNA. Translation: AAB03660.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2EC6X-ray3.25A1-838[»]
ProteinModelPortaliQ26079.
SMRiQ26079. Positions 1-924.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ26079.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiQ26079.

Family and domain databases

Gene3Di4.10.270.10. 1 hit.
InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR027401. Myosin-like_IQ_dom.
IPR001609. Myosin_head_motor_dom.
IPR004009. Myosin_N.
IPR002928. Myosin_tail.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00063. Myosin_head. 1 hit.
PF02736. Myosin_N. 1 hit.
PF01576. Myosin_tail_1. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00015. IQ. 1 hit.
SM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50096. IQ. 1 hit.
PS51456. MYOSIN_MOTOR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Sequence variations in the surface loop near the nucleotide binding site modulate the ATP turnover rates of molluscan myosins."
    Perreault-Micale C.L., Kalabokis V.N., Nyitray L., Szent-Gyorgyi A.G.
    J. Muscle Res. Cell Motil. 17:543-553(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Striated muscleImported.
  2. Perreault-Micale C., Kalabokis V., Nyitray L., Szent-Gyorgyi A.G.
    Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Striated muscleImported.
  3. "Rigor-like structures from muscle myosins reveal key mechanical elements in the transduction pathways of this allosteric motor."
    Yang Y., Gourinath S., Kovacs M., Nyitray L., Reutzel R., Himmel D.M., O'Neall-Hennessey E., Reshetnikova L., Szent-Gyorgyi A.G., Brown J.H., Cohen C.
    Structure 15:553-564(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.25 ANGSTROMS) OF 1-838.

Entry informationi

Entry nameiQ26079_PLAMG
AccessioniPrimary (citable) accession number: Q26079
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: May 11, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.