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Q26061 (FRI_PACLE) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ferritin

EC=1.16.3.1
OrganismPacifastacus leniusculus (Signal crayfish)
Taxonomic identifier6720 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaCrustaceaMalacostracaEumalacostracaEucaridaDecapodaPleocyemataAstacideaAstacoideaAstacidaePacifastacus

Protein attributes

Sequence length181 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation By similarity.

Catalytic activity

4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

Subunit structure

Oligomer of 12 or 24 subunits. The functional molecule is roughly spherical and contains a central cavity into which the polymeric mineral iron core is deposited By similarity.

Subcellular location

Cytoplasm Potential.

Post-translational modification

The N-terminus is blocked.

Miscellaneous

There are 2 types of crayfish ferritin subunit: a 19 kDa chain and a 20 kDa chain.

Sequence similarities

Belongs to the ferritin family.

Contains 1 ferritin-like diiron domain.

Ontologies

Keywords
   Biological processIron storage
   Cellular componentCytoplasm
   LigandIron
Metal-binding
   Molecular functionOxidoreductase
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Biological_processcellular iron ion homeostasis

Inferred from electronic annotation. Source: UniProtKB-KW

iron ion transport

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionferric iron binding

Inferred from electronic annotation. Source: InterPro

ferroxidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 181181Ferritin
PRO_0000201071

Regions

Domain6 – 155150Ferritin-like diiron

Sites

Metal binding231Iron 1 By similarity
Metal binding581Iron 1 By similarity
Metal binding581Iron 2 By similarity
Metal binding611Iron 1 By similarity
Metal binding1031Iron 2 By similarity
Metal binding1371Iron 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q26061 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: C7318FC910178C55

FASTA18120,671
        10         20         30         40         50         60 
MASQIRHNYH EDCEPINKQI NLEFYASYVY MSMGHYFDRD DISLPGASKF FKDSSDEERE 

        70         80         90        100        110        120 
HGQKLMKYQN KRGARIVLQA IAAPSLQEWG NLHDALQAAL DLENEVNQSL LDLDATASKI 

       130        140        150        160        170        180 
NDPHLTNMLE GEFLEEQVES IEKIGNLITR LKRAGTSGLG EFLFDKELKQ RFLPSLTSHP 


N 

« Hide

References

[1]"Purification and cDNA cloning of ferritin from the hepatopancreas of the freshwater crayfish Pacifastacus leniusculus."
Huang T.-S., Law J.H., Soederhaell K.
Eur. J. Biochem. 236:450-456(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 76-88.
Tissue: Hepatopancreas.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X90566 mRNA. Translation: CAA62186.1.
PIRS62651.

3D structure databases

ProteinModelPortalQ26061.
SMRQ26061. Positions 2-168.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.20.1260.10. 1 hit.
InterProIPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR008331. Ferritin_DPS_dom.
[Graphical view]
PANTHERPTHR11431. PTHR11431. 1 hit.
PfamPF00210. Ferritin. 1 hit.
[Graphical view]
SUPFAMSSF47240. SSF47240. 1 hit.
PROSITEPS50905. FERRITIN_LIKE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFRI_PACLE
AccessionPrimary (citable) accession number: Q26061
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2002
Last sequence update: November 1, 1996
Last modified: February 19, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families