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Protein

Ferritin

Gene
N/A
Organism
Pacifastacus leniusculus (Signal crayfish)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation (By similarity).By similarity

Miscellaneous

There are 2 types of crayfish ferritin subunit: a 19 kDa chain and a 20 kDa chain.

Catalytic activityi

4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi23Iron 1PROSITE-ProRule annotation1
Metal bindingi58Iron 1PROSITE-ProRule annotation1
Metal bindingi58Iron 2PROSITE-ProRule annotation1
Metal bindingi61Iron 1PROSITE-ProRule annotation1
Metal bindingi103Iron 2PROSITE-ProRule annotation1
Metal bindingi137Iron 2PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processIron storage
LigandIron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ferritin (EC:1.16.3.1)
OrganismiPacifastacus leniusculus (Signal crayfish)
Taxonomic identifieri6720 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaCrustaceaMalacostracaEumalacostracaEucaridaDecapodaPleocyemataAstacideaAstacoideaAstacidaePacifastacus

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002010711 – 181FerritinAdd BLAST181

Post-translational modificationi

The N-terminus is blocked.

Interactioni

Subunit structurei

Oligomer of 12 or 24 subunits. The functional molecule is roughly spherical and contains a central cavity into which the polymeric mineral iron core is deposited (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ26061.
SMRiQ26061.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 155Ferritin-like diironPROSITE-ProRule annotationAdd BLAST150

Sequence similaritiesi

Belongs to the ferritin family.Curated

Family and domain databases

Gene3Di1.20.1260.10. 1 hit.
InterProiView protein in InterPro
IPR001519. Ferritin.
IPR012347. Ferritin-like.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR008331. Ferritin_DPS_dom.
PANTHERiPTHR11431. PTHR11431. 1 hit.
PfamiView protein in Pfam
PF00210. Ferritin. 1 hit.
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiView protein in PROSITE
PS50905. FERRITIN_LIKE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q26061-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASQIRHNYH EDCEPINKQI NLEFYASYVY MSMGHYFDRD DISLPGASKF
60 70 80 90 100
FKDSSDEERE HGQKLMKYQN KRGARIVLQA IAAPSLQEWG NLHDALQAAL
110 120 130 140 150
DLENEVNQSL LDLDATASKI NDPHLTNMLE GEFLEEQVES IEKIGNLITR
160 170 180
LKRAGTSGLG EFLFDKELKQ RFLPSLTSHP N
Length:181
Mass (Da):20,671
Last modified:November 1, 1996 - v1
Checksum:iC7318FC910178C55
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X90566 mRNA. Translation: CAA62186.1.
PIRiS62651.

Similar proteinsi

Entry informationi

Entry nameiFRI_PACLE
AccessioniPrimary (citable) accession number: Q26061
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2002
Last sequence update: November 1, 1996
Last modified: November 22, 2017
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families