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Q26061

- FRI_PACLE

UniProt

Q26061 - FRI_PACLE

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Protein

Ferritin

Gene
N/A
Organism
Pacifastacus leniusculus (Signal crayfish)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation By similarity.

Catalytic activityi

4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi23 – 231Iron 1 By similarity
Metal bindingi58 – 581Iron 1 By similarity
Metal bindingi58 – 581Iron 2 By similarity
Metal bindingi61 – 611Iron 1 By similarity
Metal bindingi103 – 1031Iron 2 By similarity
Metal bindingi137 – 1371Iron 2 By similarity

GO - Molecular functioni

  1. ferric iron binding Source: InterPro
  2. ferroxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. cellular iron ion homeostasis Source: UniProtKB-KW
  2. iron ion transport Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Iron storage

Keywords - Ligandi

Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ferritin (EC:1.16.3.1)
OrganismiPacifastacus leniusculus (Signal crayfish)
Taxonomic identifieri6720 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaCrustaceaMalacostracaEumalacostracaEucaridaDecapodaPleocyemataAstacideaAstacoideaAstacidaePacifastacus

Subcellular locationi

Cytoplasm Reviewed prediction

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 181181FerritinPRO_0000201071Add
BLAST

Post-translational modificationi

The N-terminus is blocked.

Interactioni

Subunit structurei

Oligomer of 12 or 24 subunits. The functional molecule is roughly spherical and contains a central cavity into which the polymeric mineral iron core is deposited By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ26061.
SMRiQ26061. Positions 2-168.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 155150Ferritin-like diironAdd
BLAST

Sequence similaritiesi

Belongs to the ferritin family.

Family and domain databases

Gene3Di1.20.1260.10. 1 hit.
InterProiIPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR008331. Ferritin_DPS_dom.
[Graphical view]
PANTHERiPTHR11431. PTHR11431. 1 hit.
PfamiPF00210. Ferritin. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS50905. FERRITIN_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q26061-1 [UniParc]FASTAAdd to Basket

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MASQIRHNYH EDCEPINKQI NLEFYASYVY MSMGHYFDRD DISLPGASKF    50
FKDSSDEERE HGQKLMKYQN KRGARIVLQA IAAPSLQEWG NLHDALQAAL 100
DLENEVNQSL LDLDATASKI NDPHLTNMLE GEFLEEQVES IEKIGNLITR 150
LKRAGTSGLG EFLFDKELKQ RFLPSLTSHP N 181
Length:181
Mass (Da):20,671
Last modified:November 1, 1996 - v1
Checksum:iC7318FC910178C55
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X90566 mRNA. Translation: CAA62186.1.
PIRiS62651.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X90566 mRNA. Translation: CAA62186.1 .
PIRi S62651.

3D structure databases

ProteinModelPortali Q26061.
SMRi Q26061. Positions 2-168.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.20.1260.10. 1 hit.
InterProi IPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR008331. Ferritin_DPS_dom.
[Graphical view ]
PANTHERi PTHR11431. PTHR11431. 1 hit.
Pfami PF00210. Ferritin. 1 hit.
[Graphical view ]
SUPFAMi SSF47240. SSF47240. 1 hit.
PROSITEi PS50905. FERRITIN_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Purification and cDNA cloning of ferritin from the hepatopancreas of the freshwater crayfish Pacifastacus leniusculus."
    Huang T.-S., Law J.H., Soederhaell K.
    Eur. J. Biochem. 236:450-456(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 76-88.
    Tissue: Hepatopancreas.

Entry informationi

Entry nameiFRI_PACLE
AccessioniPrimary (citable) accession number: Q26061
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2002
Last sequence update: November 1, 1996
Last modified: February 19, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Miscellaneous

There are 2 types of crayfish ferritin subunit: a 19 kDa chain and a 20 kDa chain.

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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