Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q26061

- FRI_PACLE

UniProt

Q26061 - FRI_PACLE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Ferritin

Gene
N/A
Organism
Pacifastacus leniusculus (Signal crayfish)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation By similarity.By similarity

Catalytic activityi

4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi23 – 231Iron 1PROSITE-ProRule annotation
Metal bindingi58 – 581Iron 1PROSITE-ProRule annotation
Metal bindingi58 – 581Iron 2PROSITE-ProRule annotation
Metal bindingi61 – 611Iron 1PROSITE-ProRule annotation
Metal bindingi103 – 1031Iron 2PROSITE-ProRule annotation
Metal bindingi137 – 1371Iron 2PROSITE-ProRule annotation

GO - Molecular functioni

  1. ferric iron binding Source: InterPro
  2. ferroxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. cellular iron ion homeostasis Source: UniProtKB-KW
  2. iron ion transport Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Iron storage

Keywords - Ligandi

Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ferritin (EC:1.16.3.1)
OrganismiPacifastacus leniusculus (Signal crayfish)
Taxonomic identifieri6720 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaCrustaceaMalacostracaEumalacostracaEucaridaDecapodaPleocyemataAstacideaAstacoideaAstacidaePacifastacus

Subcellular locationi

Cytoplasm Curated

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 181181FerritinPRO_0000201071Add
BLAST

Post-translational modificationi

The N-terminus is blocked.

Interactioni

Subunit structurei

Oligomer of 12 or 24 subunits. The functional molecule is roughly spherical and contains a central cavity into which the polymeric mineral iron core is deposited By similarity.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ26061.
SMRiQ26061. Positions 2-168.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 155150Ferritin-like diironPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ferritin family.Curated
Contains 1 ferritin-like diiron domain.PROSITE-ProRule annotation

Family and domain databases

Gene3Di1.20.1260.10. 1 hit.
InterProiIPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR008331. Ferritin_DPS_dom.
[Graphical view]
PANTHERiPTHR11431. PTHR11431. 1 hit.
PfamiPF00210. Ferritin. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS50905. FERRITIN_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q26061-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASQIRHNYH EDCEPINKQI NLEFYASYVY MSMGHYFDRD DISLPGASKF
60 70 80 90 100
FKDSSDEERE HGQKLMKYQN KRGARIVLQA IAAPSLQEWG NLHDALQAAL
110 120 130 140 150
DLENEVNQSL LDLDATASKI NDPHLTNMLE GEFLEEQVES IEKIGNLITR
160 170 180
LKRAGTSGLG EFLFDKELKQ RFLPSLTSHP N
Length:181
Mass (Da):20,671
Last modified:November 1, 1996 - v1
Checksum:iC7318FC910178C55
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X90566 mRNA. Translation: CAA62186.1.
PIRiS62651.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X90566 mRNA. Translation: CAA62186.1 .
PIRi S62651.

3D structure databases

ProteinModelPortali Q26061.
SMRi Q26061. Positions 2-168.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.20.1260.10. 1 hit.
InterProi IPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR008331. Ferritin_DPS_dom.
[Graphical view ]
PANTHERi PTHR11431. PTHR11431. 1 hit.
Pfami PF00210. Ferritin. 1 hit.
[Graphical view ]
SUPFAMi SSF47240. SSF47240. 1 hit.
PROSITEi PS50905. FERRITIN_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Purification and cDNA cloning of ferritin from the hepatopancreas of the freshwater crayfish Pacifastacus leniusculus."
    Huang T.-S., Law J.H., Soederhaell K.
    Eur. J. Biochem. 236:450-456(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 76-88.
    Tissue: Hepatopancreas.

Entry informationi

Entry nameiFRI_PACLE
AccessioniPrimary (citable) accession number: Q26061
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2002
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Miscellaneous

There are 2 types of crayfish ferritin subunit: a 19 kDa chain and a 20 kDa chain.

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3