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Protein

Fez family zinc finger protein 1

Gene

fezf1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Transcription repressor. Involved in the development of the forebrain region (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri247 – 26923C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri275 – 29723C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri303 – 32523C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri331 – 35323C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri359 – 38123C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri387 – 41024C2H2-type 6PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Repressor

Keywords - Biological processi

Differentiation, Neurogenesis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Fez family zinc finger protein 1
Gene namesi
Name:fezf1
Synonyms:fez
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 25

Organism-specific databases

ZFINiZDB-GENE-060929-970. fezf1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 429429Fez family zinc finger protein 1PRO_0000295116Add
BLAST

Proteomic databases

PaxDbiQ25C93.

Expressioni

Gene expression databases

BgeeiQ25C93.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000007655.

Structurei

3D structure databases

ProteinModelPortaliQ25C93.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi29 – 4416Engrailed homology 1 repressorBy similarityAdd
BLAST

Sequence similaritiesi

Contains 6 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri247 – 26923C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri275 – 29723C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri303 – 32523C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri331 – 35323C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri359 – 38123C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri387 – 41024C2H2-type 6PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00740000115096.
HOGENOMiHOG000013052.
HOVERGENiHBG098441.
InParanoidiQ25C93.
OMAiCHNATAK.
OrthoDBiEOG7Z0JW5.
PhylomeDBiQ25C93.
TreeFamiTF316780.

Family and domain databases

Gene3Di3.30.160.60. 6 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 2 hits.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 6 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q25C93-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSALYHSAG IFGAPSASTG GSMIASSKPL AFSIERIMAR TPEPKSIPFP
60 70 80 90 100
NLFQAPVGKA EPKQSPAPLH CMIPLMPLAC EPPHKLHING LDHPDTFAYN
110 120 130 140 150
ANELLSIGLN YKNEQQDAAP AIGQYKLFRP RVVNQSSFHA MGAAVCYLNC
160 170 180 190 200
GEGACPPHAG LVNLHPMASY LLNTPLHARQ KSLFSSEKSK QGAVADRCPP
210 220 230 240 250
GVSFKELSHS HLHHYMKESA HILSEKLFKN SAAKVNSGSP QTKPKVFTCE
260 270 280 290 300
VCGKVFNAHY NLTRHMPVHT GARPFVCKVC GKGFRQASTL CRHKIIHTQE
310 320 330 340 350
KPHKCNQCGK AFNRSSTLNT HTRIHAGYKP FICEFCGKGF HQKGNYKNHK
360 370 380 390 400
LTHSGEKQFK CNICNKAFHQ VYNLTFHMHT HNDKKPFTCP TCGKGFCRNF
410 420
DLKKHIRKLH DISPGPHSPP TPTGNTEGQ
Length:429
Mass (Da):47,395
Last modified:April 18, 2006 - v1
Checksum:iF5814DEC4BE4198A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB207804 mRNA. Translation: BAE87036.1.
BC124439 mRNA. Translation: AAI24440.1.
RefSeqiNP_001107820.1. NM_001114348.1.
UniGeneiDr.78747.

Genome annotation databases

EnsembliENSDART00000010325; ENSDARP00000007655; ENSDARG00000010270.
GeneIDi558801.
KEGGidre:558801.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB207804 mRNA. Translation: BAE87036.1.
BC124439 mRNA. Translation: AAI24440.1.
RefSeqiNP_001107820.1. NM_001114348.1.
UniGeneiDr.78747.

3D structure databases

ProteinModelPortaliQ25C93.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000007655.

Proteomic databases

PaxDbiQ25C93.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000010325; ENSDARP00000007655; ENSDARG00000010270.
GeneIDi558801.
KEGGidre:558801.

Organism-specific databases

CTDi389549.
ZFINiZDB-GENE-060929-970. fezf1.

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00740000115096.
HOGENOMiHOG000013052.
HOVERGENiHBG098441.
InParanoidiQ25C93.
OMAiCHNATAK.
OrthoDBiEOG7Z0JW5.
PhylomeDBiQ25C93.
TreeFamiTF316780.

Miscellaneous databases

NextBioi20882636.
PROiQ25C93.

Gene expression databases

BgeeiQ25C93.

Family and domain databases

Gene3Di3.30.160.60. 6 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 2 hits.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 6 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 6 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Zinc-finger gene Fez in the olfactory sensory neurons regulates development of the olfactory bulb non-cell-autonomously."
    Hirata T., Nakazawa M., Yoshihara S., Miyachi H., Kitamura K., Yoshihara Y., Hibi M.
    Development 133:1433-1443(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Olfactory epithelium.

Entry informationi

Entry nameiFEZF1_DANRE
AccessioniPrimary (citable) accession number: Q25C93
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: April 18, 2006
Last modified: May 11, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.