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Protein

Akirin-2

Gene

Akirin2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for the innate immune response. Downstream effector of the Toll-like receptor (TLR), TNF and IL-1 beta signaling pathways leading to the production of IL-6 (By similarity). Forms a complex with YWHAB that acts to repress transcription of DUSP1.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

  • embryo development ending in birth or egg hatching Source: Ensembl
  • innate immune response Source: UniProtKB-KW
  • negative regulation of gene expression Source: RGD
  • negative regulation of transcription, DNA-templated Source: RGD
  • negative regulation of transcription by RNA polymerase II Source: RGD
  • positive regulation of cell proliferation Source: RGD
  • positive regulation of endopeptidase activity Source: RGD
  • positive regulation of interleukin-6 production Source: RGD
  • positive regulation of transcription by RNA polymerase II Source: RGD
  • response to lipopolysaccharide Source: RGD
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDevelopmental protein, Repressor
Biological processImmunity, Innate immunity, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Akirin-2
Alternative name(s):
Fourteen-three-three beta interactant 1Imported
Fourteen-three-three beta interacting-protein 1
Gene namesi
Name:Akirin2By similarity
Synonyms:FBI1Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi1307791 Akirin2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi31S → A: Abolishes binding to YWHAB. Reduces transcriptional repressor activity; when associated with A-111 and A-119. 1 Publication1
Mutagenesisi103T → A: Abolishes binding to YWHAB. Loss of transcriptional repressor activity; when associated with A-111; A-119 and A-131. 1 Publication1
Mutagenesisi111S → A: Abolishes binding to YWHAB. Loss of transcriptional repressor activity; when associated with A-103; A-119 and A-131. Reduces transcriptional repressor activity; when associated with A-31 and A-119. 1 Publication1
Mutagenesisi119S → A: Abolishes binding to YWHAB. Loss of transcriptional repressor activity; when associated with A-103; A-111 and A-131. Reduces transcriptional repressor activity; when associated with A-31 and A-111. 1 Publication1
Mutagenesisi131S → A: Abolishes binding to YWHAB. Loss of transcriptional repressor activity; when associated with A-103; A-111 and A-119. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003551221 – 201Akirin-2Add BLAST201

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei18PhosphoserineBy similarity1
Modified residuei21PhosphoserineCombined sources1
Modified residuei55PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ25C79
PRIDEiQ25C79

PTM databases

iPTMnetiQ25C79
PhosphoSitePlusiQ25C79

Expressioni

Tissue specificityi

Highly expressed in testis, cerebrum and cerebellum, and barely detectable in liver, heart, spleen and muscle. Also highly expressed in various tumor cells from hepatoma, glioblastoma and pheochromocytoma.1 Publication

Gene expression databases

BgeeiENSRNOG00000008288
GenevisibleiQ25C79 RN

Interactioni

Subunit structurei

Interacts with YWHAB.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ25C79, 1 interactor
MINTiQ25C79
STRINGi10116.ENSRNOP00000010962

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi22 – 27Nuclear localization signal6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi28 – 54Ala-richSequence analysisAdd BLAST27

Sequence similaritiesi

Belongs to the akirin family.Curated

Phylogenomic databases

eggNOGiKOG4330 Eukaryota
ENOG4111J00 LUCA
GeneTreeiENSGT00390000007905
HOGENOMiHOG000231406
HOVERGENiHBG055078
InParanoidiQ25C79
OMAiKMAENLC
OrthoDBiEOG091G0PVD
PhylomeDBiQ25C79
TreeFamiTF317123

Family and domain databases

InterProiView protein in InterPro
IPR024132 Akirin
PANTHERiPTHR13293 PTHR13293, 1 hit

Sequencei

Sequence statusi: Complete.

Q25C79-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MACGATLKRT LDFDPLLSPA SPKRRRCAPL SAPASAAASP AAATAAAAAS
60 70 80 90 100
AAAASPQKYL RMEPSPFGDV SSRLTTEQIL YNIKQEYKRM QKRRHLEASF
110 120 130 140 150
QQTDPGCSSD SQPHAFLISG PASPGTSSAT SSPLKKEQPL FTLRQVGMIC
160 170 180 190 200
ERLLKEREEK VREEYEEILN TKLAEQYDAF VKFTHDQIMR RYGEQPASYV

S
Length:201
Mass (Da):22,129
Last modified:April 18, 2006 - v1
Checksum:i2DEC2AA36F95C1BB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB234867 mRNA Translation: BAE81786.1
CH473962 Genomic DNA Translation: EDL98593.1
RefSeqiNP_001035003.1, NM_001039914.2
UniGeneiRn.3858

Genome annotation databases

EnsembliENSRNOT00000010962; ENSRNOP00000010962; ENSRNOG00000008288
GeneIDi297968
KEGGirno:297968
UCSCiRGD:1307791 rat

Similar proteinsi

Entry informationi

Entry nameiAKIR2_RAT
AccessioniPrimary (citable) accession number: Q25C79
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: April 18, 2006
Last modified: March 28, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health