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Protein
Submitted name:

Estrogen receptor beta

Gene

esr2

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi164 – 239Nuclear receptorPROSITE-ProRule annotationAdd BLAST76

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingPROSITE-ProRule annotationSAAS annotation, ReceptorUniRule annotationSAAS annotationImported
Biological processTranscription, Transcription regulationUniRule annotationSAAS annotation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
Estrogen receptor betaImported
Gene namesi
Name:esr2Imported
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)Imported
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana

Organism-specific databases

XenbaseiXB-GENE-486256. esr2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliQ25C13.
SMRiQ25C13.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini164 – 239Nuclear receptorInterPro annotationAdd BLAST76

Sequence similaritiesi

Belongs to the nuclear hormone receptor family. NR3 subfamily.UniRule annotation

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG3575. Eukaryota.
ENOG410XRZC. LUCA.
HOVERGENiHBG108344.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiView protein in InterPro
IPR028355. ER-beta/gamma.
IPR021064. Estrogen_rcpt_beta_N.
IPR035500. NHR_like_dom_sf.
IPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR024178. Oest_rcpt/oest-rel_rcp.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
PfamiView protein in Pfam
PF12497. ERbeta_N. 1 hit.
PF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
PIRSFiPIRSF500102. ER-b. 1 hit.
PIRSF002527. ER-like_NR. 1 hit.
PRINTSiPR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiView protein in SMART
SM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiView protein in PROSITE
PS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q25C13-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTYMHKEYS QLQPMQHILH GKADIKSSPS AINSSVPYSG TVPMDQSPMY
60 70 80 90 100
TPSSYLDSRH DYPSITFCSP SLINYNVPGS DSESSVLRQT VSPGLLWTSP
110 120 130 140 150
DHMSPVTLHC QSSLLYTEAP TSPWFEAKSE EHILPLSRES LKRKSMGSEC
160 170 180 190 200
ANNVGSNPGS KRDTHFCAVC SDYASGYHYG VWSCEGCKAF FKRSIQGHND
210 220 230 240 250
YICPATNQCT IDKNRRKSCQ ACRLRKCFEV GMMKCGTRRE RCGYRIVRHR
260 270 280 290 300
RHSDDQMHCL AKNKKLTDNI QRVKEISASS LGPEQFVLII SDAEPPNVML
310 320 330 340 350
MNRLCKPFTE ASMMMSLTKL ADKELVHMIG WAKKIPGFVE LSLYDQVRLL
360 370 380 390 400
ESCWLEILMM GLMWRSIDHP GKLLFAPDLT LDRDEGKCVE GILEIFDMLL
410 420 430 440 450
ATTSRLRELK LQHREFLCLK VMILLNSHVF PLTSSEEESE SSRKLHHPLN
460 470 480 490 500
TVTDALVWVI AKSGIPFRQQ STRLANLLML LSHVRHASNK GMEHLLSMKC
510 520 530 540
KNVVPVYDLL LEMLNAHTLR DHRKSTLAIS NYSSKAESEA RDAGQPTQ
Length:548
Mass (Da):62,053
Last modified:April 18, 2006 - v1
Checksum:iD63AA54459B384AD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB244212 mRNA. Translation: BAE81789.1.
RefSeqiNP_001035101.1. NM_001040012.2.
UniGeneiStr.8691.

Genome annotation databases

GeneIDi394460.

Similar proteinsi

Entry informationi

Entry nameiQ25C13_XENTR
AccessioniPrimary (citable) accession number: Q25C13
Entry historyiIntegrated into UniProtKB/TrEMBL: April 18, 2006
Last sequence update: April 18, 2006
Last modified: January 31, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)