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Protein

Nuclear egress protein 1

Gene

UL31

Organism
Human herpesvirus 1 (HHV-1) (Human herpes simplex virus 1)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Plays an essential role in virion nuclear egress, the first step of virion release from infected cell. Within the host nucleus, NEC1 interacts with the newly formed capsid through the vertexes and directs it to the inner nuclear membrane by associating with NEC2. Induces the budding of the capsid at the inner nuclear membrane as well as its envelopment into the perinuclear space. There, the NEC1/NEC2 complex promotes the fusion of the enveloped capsid with the outer nuclear membrane and the subsequent release of the viral capsid into the cytoplasm where it will reach the secondary budding sites in the host Golgi or trans-Golgi network.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri106 – 225CCCH-typeUniRule annotationAdd BLAST120

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear egress protein 1UniRule annotation
Gene namesi
Name:UL31Imported
Synonyms:NEC1UniRule annotation
ORF Names:HHV1gp048Imported
OrganismiHuman herpesvirus 1 (HHV-1) (Human herpes simplex virus 1)Imported
Taxonomic identifieri10298 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000126435 Componenti: Genome
  • UP000121444 Componenti: Genome
  • UP000180758 Componenti: Genome

Subcellular locationi

  • Host nucleus inner membrane UniRule annotation
  • Note: Remains attached to the nucleus inner membrane through interaction with NEC2.UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Host membraneUniRule annotation, Host nucleusUniRule annotation, Membrane

PTM / Processingi

Post-translational modificationi

Phosphorylated at serine residues in the N-terminus. This phosphorylation regulates the localization within the inner nuclear membrane.UniRule annotation

Keywords - PTMi

PhosphoproteinUniRule annotation

Interactioni

Subunit structurei

Forms a heterohexameric complex with NEC2. Interacts with capsid vertex specific component 2/CVC2; this interaction directs the capsid to the host inner nuclear membrane to initiate budding.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the herpesviridae NEC1 protein family.UniRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri106 – 225CCCH-typeUniRule annotationAdd BLAST120

Keywords - Domaini

Zinc-fingerUniRule annotation

Family and domain databases

HAMAPiMF_04023. HSV_NEC1. 1 hit.
InterProiView protein in InterPro
IPR021152. Herpes_UL31.
PfamiView protein in Pfam
PF02718. Herpes_UL31. 1 hit.

Sequencei

Sequence statusi: Complete.

Q25BX0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYDTDPHRRG SRPGPYHGKE RRRSRSSAAG GTLGVVRRAS RKSLPPHARK
60 70 80 90 100
QELCLHERQR YRGLFAALAQ TPSEEIAIVR SLSVPLVKTT PVSLPFCLDQ
110 120 130 140 150
TVADNCLTLS GMGYYLGIGG CCPACNAGDG RFAATSREAL ILAFVQQINT
160 170 180 190 200
IFEHRAFLAS LVVLADRHNA PLQDLLAGIL GQPELFFVHT ILRGGGACDP
210 220 230 240 250
RLLFYPDPTY GGHMLYVIFP GTSAHLHYRL IDRMLTACPG YRFVAHVWQS
260 270 280 290 300
TFVLVVRRNA EKPTDAEIPT VSAADIYCKM RDISFDGGLM LEYQRLYATF

DEFPPP
Length:306
Mass (Da):33,953
Last modified:April 18, 2006 - v1
Checksum:iD4FE0FD98D934C46
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ889502 Genomic DNA. Translation: ABI63493.1.
GU734771 Genomic DNA. Translation: ADD60001.1.
GU734772 Genomic DNA. Translation: ADD60078.1.
HM585496 Genomic DNA. Translation: ADM22354.1.
HM585497 Genomic DNA. Translation: ADM22431.1.
HM585498 Genomic DNA. Translation: ADM22507.1.
HM585499 Genomic DNA. Translation: ADM22584.1.
HM585500 Genomic DNA. Translation: ADM22661.1.
HM585501 Genomic DNA. Translation: ADM22738.1.
HM585502 Genomic DNA. Translation: ADM22814.1.
HM585503 Genomic DNA. Translation: ADM22891.1.
HM585505 Genomic DNA. Translation: ADM23044.1.
HM585506 Genomic DNA. Translation: ADM23120.1.
HM585507 Genomic DNA. Translation: ADM23197.1.
HM585510 Genomic DNA. Translation: ADM23422.1.
HM585511 Genomic DNA. Translation: ADM23496.1.
HM585512 Genomic DNA. Translation: ADM23570.1.
HM585513 Genomic DNA. Translation: ADM23645.1.
HM585514 Genomic DNA. Translation: ADM23720.1.
HM585515 Genomic DNA. Translation: ADM23796.1.
JN555585 Genomic DNA. Translation: AEQ77062.1.
JN420337 Genomic DNA. Translation: AER37685.1.
JQ730035 Genomic DNA. Translation: AFK50377.1.
JX142173 Genomic DNA. Translation: AFP86395.1.
KM222724 Genomic DNA. Translation: AJE60189.1.
KM222725 Genomic DNA. Translation: AJE60262.1.
KM222726 Genomic DNA. Translation: AJE60332.1.
KM222727 Genomic DNA. Translation: AJE60405.1.
KT425107 Genomic DNA. Translation: ALM22600.1.
KU310657 Genomic DNA. Translation: AMB65629.1.
KU310658 Genomic DNA. Translation: AMB65702.1.
KU310659 Genomic DNA. Translation: AMB65776.1.
KU310660 Genomic DNA. Translation: AMB65849.1.
KX946970 Genomic DNA. Translation: AOY36650.1.
AB252864 Genomic DNA. Translation: BAE87040.1.
LT594105 Genomic DNA. Translation: SBS69261.1.
LT594107 Genomic DNA. Translation: SBS69333.1.
LT594112 Genomic DNA. Translation: SBS69373.1.
LT594109 Genomic DNA. Translation: SBS69492.1.
LT594111 Genomic DNA. Translation: SBS69513.1.
LT594192 Genomic DNA. Translation: SBS69777.1.
RefSeqiYP_009137106.1. NC_001806.2.

Genome annotation databases

GeneIDi2703350.
KEGGivg:2703350.

Similar proteinsi

Entry informationi

Entry nameiQ25BX0_HHV1
AccessioniPrimary (citable) accession number: Q25BX0
Entry historyiIntegrated into UniProtKB/TrEMBL: April 18, 2006
Last sequence update: April 18, 2006
Last modified: November 22, 2017
This is version 50 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported