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Protein

Phosphomannomutase

Gene

PMM

Organism
Oryza sativa subsp. indica (Rice)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in ascorbic acid biosynthesis and in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.By similarity

Catalytic activityi

Alpha-D-mannose 1-phosphate = D-mannose 6-phosphate.

Pathwayi: GDP-alpha-D-mannose biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes alpha-D-mannose 1-phosphate from D-fructose 6-phosphate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Phosphomannomutase (PMM), Phosphomannomutase (OsI_17966), Phosphomannomutase (Os04g58580)
This subpathway is part of the pathway GDP-alpha-D-mannose biosynthesis, which is itself part of Nucleotide-sugar biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes alpha-D-mannose 1-phosphate from D-fructose 6-phosphate, the pathway GDP-alpha-D-mannose biosynthesis and in Nucleotide-sugar biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei14NucleophileBy similarity1
Active sitei16Proton donor/acceptorSequence analysis1
Binding sitei23SubstrateBy similarity1
Binding sitei125SubstrateBy similarity1
Binding sitei136SubstrateBy similarity1
Binding sitei143SubstrateBy similarity1
Binding sitei181SubstrateBy similarity1
Binding sitei183SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase

Enzyme and pathway databases

ReactomeiR-OSA-446205 Synthesis of GDP-mannose
UniPathwayiUPA00126; UER00424

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphomannomutase (EC:5.4.2.8)
Short name:
OsPMM
Gene namesi
Name:PMM
ORF Names:H0124B04.12, OsI_017323
OrganismiOryza sativa subsp. indica (Rice)
Taxonomic identifieri39946 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryzaOryza sativa
Proteomesi
  • UP000007015 Componenti: Chromosome 4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003264921 – 248PhosphomannomutaseAdd BLAST248

Proteomic databases

PRIDEiQ259G4

Expressioni

Gene expression databases

ExpressionAtlasiQ259G4 differential

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi39946.BGIOSGA017373-PA

Structurei

3D structure databases

ProteinModelPortaliQ259G4
SMRiQ259G4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the eukaryotic PMM family.Curated

Phylogenomic databases

eggNOGiKOG3189 Eukaryota
COG0561 LUCA

Family and domain databases

CDDicd02585 HAD_PMM, 1 hit
Gene3Di3.40.50.1000, 2 hits
InterProiView protein in InterPro
IPR036412 HAD-like_sf
IPR006379 HAD-SF_hydro_IIB
IPR023214 HAD_sf
IPR005002 PMM
PANTHERiPTHR10466 PTHR10466, 1 hit
PfamiView protein in Pfam
PF03332 PMM, 1 hit
SFLDiSFLDG01143 C2.B.3:_Phosphomannomutase_Lik, 1 hit
SUPFAMiSSF56784 SSF56784, 1 hit
TIGRFAMsiTIGR01484 HAD-SF-IIB, 1 hit

Sequencei

Sequence statusi: Complete.

Q259G4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAARKNAGVL ALFDVDGTLT APRKVVTPEM LQFMKQLREH VTVGVVGGSD
60 70 80 90 100
LVKISEQLGK SVTTDYDYCF SENGLVAHKN GELIGTQSLK SFLGDDQLKE
110 120 130 140 150
FINFTLHYIA DLDIPIKRGT FIEFRSGMLN VSPIGRNCSQ EERDEFEKYD
160 170 180 190 200
KVHNIRPKMV SVLREKFAHL NLTFSIGGQI SFDVFPQGWD KTYCLRYLEE
210 220 230 240
FQEIHFFGDK TYKGGNDYEI FESDRTIGHT VTSPDDTAEQ CRSLFMSK
Length:248
Mass (Da):28,193
Last modified:April 18, 2006 - v1
Checksum:iC28CA4DD5B233DE5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL732352 Genomic DNA Translation: CAJ86295.1
CM000129 Genomic DNA No translation available.

Genome annotation databases

EnsemblPlantsiOs04t0682300-01; Os04t0682300-01; Os04g0682300
GrameneiOs04t0682300-01; Os04t0682300-01; Os04g0682300

Similar proteinsi

Entry informationi

Entry nameiPMM_ORYSI
AccessioniPrimary (citable) accession number: Q259G4
Secondary accession number(s): A2XZ30
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: April 18, 2006
Last modified: May 23, 2018
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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