Reviewed, UniProtKB/Swiss-Prot Q256I5 (NTPA_CHLFF)

Names and origin

Protein names

Recommended name:
    Nucleoside-triphosphatase
    EC=3.6.1.15
Alternative name(s):
    Nucleoside triphosphate phosphohydrolase
      Short name=NTPase

Gene names

Ordered Locus Names:

CF0031

Organism

Chlamydophila felis (strain Fe/C-56) [Complete proteome] [HAMAP]

Taxonomic identifier

264202 [NCBI]

Taxonomic lineage

Bacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydophila

Protein attributes

Sequence length	206 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Hydrolyzes non-standard nucleotides such as XTP and dITP/ITP. Might exclude non-standard purines from DNA precursor pool, preventing thus incorporation into DNA and avoiding chromosomal lesions By similarity.
Catalytic activity	NTP + H(2)O = NDP + phosphate.
Cofactor	Divalent cations By similarity.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the HAM1 NTPase family.

Ontologies

Keywords
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	nucleoside-triphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 206	206	Nucleoside-triphosphatase		PRO_1000068416

Sequences

	Sequence		Length	Mass (Da)
	Q256I5-1 [UniParc]. Last modified April 18, 2006. Version 1. Checksum: E5727E0D87C95056	FASTA	206	23,104
	10 20 30 40 50 60 MKIVIASSHG YKIRETKTFL KQLGSFDIFS LADFPDYYAP KEIGSLPEDN ALAKGLHAAK 70 80 90 100 110 120 ELNSWVIADD TMLMVPALNG LPGKFSATFA GEDACDKDHR KKLLQEMQSL ESIVDRSAYF 130 140 150 160 170 180 ECCVVLASPE GKFFKSRGIC EGYISNHEKG SSGFGYDSLF LKYDYKQTFA ELSEDVKNQV 190 200 SHRAKALQKL TPYLQDLLEK HLVSRN

References

[1]

"Genome sequence of the cat pathogen, Chlamydophila felis." Azuma Y., Hirakawa H., Yamashita A., Cai Y., Rahman M.A., Suzuki H., Mitaku S., Toh H., Goto S., Murakami T., Sugi K., Hayashi H., Fukushi H., Hattori M., Kuhara S., Shirai M. DNA Res. 13:15-23(2006) [PubMed: 16766509] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AP006861 Genomic DNA. Translation: BAE80803.1.
RefSeq	YP_514948.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3958805.
GenomeReviews	Gene locus CF0031 in contig AP006861_GR.
KEGG	cfe:CF0031.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q256I5.
Family and domain databases
HAMAP	MF_01405. [Tree]
InterPro	IPR002637. Ham1p_like. [Graphical view]
PANTHER	PTHR11067. Ham1p_like. 1 hit.
Pfam	PF01725. Ham1p_like. 1 hit. [Graphical view]
TIGRFAMs	TIGR00042. Ham1p_like. 1 hit.
ProtoNet	Search...

Entry information

Entry name

NTPA_CHLFF

Accession

Primary (citable) accession number: Q256I5

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	April 18, 2006
Last modified:	July 22, 2008
This is version 17 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)