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Protein

Tropomyosin

Gene

tmy-1

Organism
Onchocerca volvulus
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction.

Names & Taxonomyi

Protein namesi
Recommended name:
Tropomyosin
Alternative name(s):
MOv-14
Ov-tmy-1
Gene namesi
Name:tmy-1
OrganismiOnchocerca volvulus
Taxonomic identifieri6282 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaSpiruridaFilarioideaOnchocercidaeOnchocerca
Proteomesi
  • UP000024404 Componenti: Unassembled WGS sequence

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002056471 – 284TropomyosinAdd BLAST284

Proteomic databases

PRIDEiQ25632.

Expressioni

Developmental stagei

Present in all life-cycle stages.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ25632.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1 – 284Add BLAST284

Domaini

The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.

Sequence similaritiesi

Belongs to the tropomyosin family.Curated

Keywords - Domaini

Coiled coil, Repeat

Family and domain databases

InterProiIPR000533. Tropomyosin.
[Graphical view]
PfamiPF00261. Tropomyosin. 1 hit.
[Graphical view]
PRINTSiPR00194. TROPOMYOSIN.
PROSITEiPS00326. TROPOMYOSIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q25632-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDAIKKKMQA MKIEKDNALD RADAAEEKVR QMTEKLERIE EELRDTQKKM
60 70 80 90 100
MQTENDLVKA QEDLSVANTN LEDKEKKVQE AEAEVAALNR RMTLLEEELE
110 120 130 140 150
RAEERLKIAT DKLEEATHTA DESERVRKVM ENRSFQDEER ANTVESQEKE
160 170 180 190 200
AQLLAEEADR KYDEVARKLA MVEADLERAE ERAEAGENEI VELEEELRVV
210 220 230 240 250
GNNLKSLEVS EEKALQREDS YQEQIRTVSV RLKEAETRAE FAERSVQKLQ
260 270 280
KKVDRLEDEL VHEKERYKNI SEELDQTFQE LSGY
Length:284
Mass (Da):33,235
Last modified:November 1, 1996 - v1
Checksum:i4535A43E593DE7E0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L41633 mRNA. Translation: AAC28900.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L41633 mRNA. Translation: AAC28900.1.

3D structure databases

ProteinModelPortaliQ25632.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ25632.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR000533. Tropomyosin.
[Graphical view]
PfamiPF00261. Tropomyosin. 1 hit.
[Graphical view]
PRINTSiPR00194. TROPOMYOSIN.
PROSITEiPS00326. TROPOMYOSIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTPM_ONCVO
AccessioniPrimary (citable) accession number: Q25632
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: November 1, 1996
Last modified: October 5, 2016
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.