Q255P5 (LPXB_CHLFF) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Lipid-A-disaccharide synthase
EC=2.4.1.182

Gene names

Name:	lpxB
Ordered Locus Names:	CF0221

Organism

Chlamydophila felis (strain Fe/C-56) [Complete proteome] [HAMAP]

Taxonomic identifier

264202 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Chlamydiae/Verrucomicrobia group › Chlamydiae › Chlamydiia › Chlamydiales › Chlamydiaceae › Chlamydia/Chlamydophila group › Chlamydophila › Chlamydophila felis

Protein attributes

Sequence length	625 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP-Rule MF_00392
Catalytic activity	UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. HAMAP-Rule MF_00392
Pathway	Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 5/6. HAMAP-Rule MF_00392
Sequence similarities	In the C-terminal section; belongs to the LpxB family.

Ontologies

Keywords
Biological process	Lipid A biosynthesis Lipid biosynthesis Lipid metabolism
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	lipid A biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular_function	lipid-A-disaccharide synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 625	625	Lipid-A-disaccharide synthase HAMAP-Rule MF_00392		PRO_0000255173
Regions
	Region	1 – 224	224	Unknown HAMAP-Rule MF_00392
	Region	225 – 625	401	Lipid-A-disaccharide synthase HAMAP-Rule MF_00392

Sequences

	Sequence		Length	Mass (Da)
	Q255P5 [UniParc]. Last modified April 18, 2006. Version 1. Checksum: 52845D7E03BE19D7	FASTA	625	71,007
	10 20 30 40 50 60 MLPLHLVHVL YPIGLIANLF FGSAFTIQWF LSERRKKACV PKSFWILSSI GAVMMIAHGF 70 80 90 100 110 120 IQSQFPIALL HGANLVIYFR NLNVSSSHSL SLRATLFILV VTLLLTTLPF VLGSYYYPNM 130 140 150 160 170 180 QWMASPNIFH LPLPPPNIYW HIAGCIGLFT FSSRFFIQWC HLEINNRSTL PALFWLVSFI 190 200 210 220 230 240 GGFLAFLYFI RTGDPVNIIS YGCGLLPSLA NLLIIYKKSR LPEFHNHSYF LSAGEPSGDI 250 260 270 280 290 300 LGSDLLHNIK TCDPTIRCFG VGGPLMRKEG FEPLIHMEEF QVSGFLEVFF SIFGLFKKYR 310 320 330 340 350 360 RLYKAILQEN PETVFCIDFP DFHFFLIKKL RKCGYKGKII HYVCPSIWAW RPKRKKILEK 370 380 390 400 410 420 YLDTLLLILP FEKDLFINSP LKTIYLGHPL VKTISNFQYC SSWKQQLSIS DQPIVALFPG 430 440 450 460 470 480 SRPGDIFRNL QVQIRAFLAS SLAQSHQILV SSCNPKYDKN ILDVLEKEGC RGKIISSTFR 490 500 510 520 530 540 YQLMRDCDCA LAKCGTIVLE AALNQTPTIV TCLLGPIDTF LAKYIFKILM PAYSLPNIIT 550 560 570 580 590 600 GSIIFPEFIG GKHDFNPEEV AAAIDILAKP KSKEKQKLAC QQLLDTLMTN VVTPEECLRI 610 620 ICSQNSHLHL EKGILKNLHP RDSSV

References

[1]

"Genome sequence of the cat pathogen, Chlamydophila felis." Azuma Y., Hirakawa H., Yamashita A., Cai Y., Rahman M.A., Suzuki H., Mitaku S., Toh H., Goto S., Murakami T., Sugi K., Hayashi H., Fukushi H., Hattori M., Kuhara S., Shirai M. DNA Res. 13:15-23(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Fe/C-56.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP006861 Genomic DNA. Translation: BAE80993.1.
RefSeq	YP_515138.1. NC_007899.1.
3D structure databases
ProteinModelPortal	Q255P5.
ModBase	Search...
Protein-protein interaction databases
STRING	264202.CF0221.
Protein family/group databases
CAZy	GT19. Glycosyltransferase Family 19.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3958442.
KEGG	cfe:CF0221.
PATRIC	20204013. VBIChlFel51660_0229.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG3952.
HOGENOM	HOG000034725.
KO	K00748.
OMA	CALAKCG.
ProtClustDB	PRK01021.
Enzyme and pathway databases
BioCyc	CFEL264202:GJCG-230-MONOMER.
UniPathway	UPA00359; UER00481.
Family and domain databases
HAMAP	MF_00392. LpxB. Fused.
InterPro	IPR003835. Glyco_trans_19. IPR011499. Lipid_A_biosynth. [Graphical view]
Pfam	PF07578. LAB_N. 2 hits. PF02684. LpxB. 1 hit. [Graphical view]
ProDom	PD339292. LAB_N. 2 hits. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...

Entry information

Entry name

LPXB_CHLFF

Accession

Primary (citable) accession number: Q255P5

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	April 18, 2006
Last modified:	May 1, 2013
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program