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Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Chlamydophila felis (strain Fe/C-56)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.By similarity

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciCFEL264202:GJCG-230-MONOMER.
UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthase (EC:2.4.1.182)
Gene namesi
Name:lpxB
Ordered Locus Names:CF0221
OrganismiChlamydophila felis (strain Fe/C-56)
Taxonomic identifieri264202 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydophila
ProteomesiUP000001260 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 625625Lipid-A-disaccharide synthasePRO_0000255173Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi264202.CF0221.

Structurei

3D structure databases

ProteinModelPortaliQ255P5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 224224UnknownAdd
BLAST
Regioni225 – 625401Lipid-A-disaccharide synthaseAdd
BLAST

Sequence similaritiesi

In the C-terminal section; belongs to the LpxB family.Curated

Phylogenomic databases

eggNOGiCOG3952.
HOGENOMiHOG000034725.
KOiK00748.
OMAiKIIHYVC.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
IPR011499. Lipid_A_biosynth.
[Graphical view]
PfamiPF07578. LAB_N. 2 hits.
PF02684. LpxB. 1 hit.
[Graphical view]
ProDomiPD339292. LAB_N. 2 hits.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Q255P5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPLHLVHVL YPIGLIANLF FGSAFTIQWF LSERRKKACV PKSFWILSSI
60 70 80 90 100
GAVMMIAHGF IQSQFPIALL HGANLVIYFR NLNVSSSHSL SLRATLFILV
110 120 130 140 150
VTLLLTTLPF VLGSYYYPNM QWMASPNIFH LPLPPPNIYW HIAGCIGLFT
160 170 180 190 200
FSSRFFIQWC HLEINNRSTL PALFWLVSFI GGFLAFLYFI RTGDPVNIIS
210 220 230 240 250
YGCGLLPSLA NLLIIYKKSR LPEFHNHSYF LSAGEPSGDI LGSDLLHNIK
260 270 280 290 300
TCDPTIRCFG VGGPLMRKEG FEPLIHMEEF QVSGFLEVFF SIFGLFKKYR
310 320 330 340 350
RLYKAILQEN PETVFCIDFP DFHFFLIKKL RKCGYKGKII HYVCPSIWAW
360 370 380 390 400
RPKRKKILEK YLDTLLLILP FEKDLFINSP LKTIYLGHPL VKTISNFQYC
410 420 430 440 450
SSWKQQLSIS DQPIVALFPG SRPGDIFRNL QVQIRAFLAS SLAQSHQILV
460 470 480 490 500
SSCNPKYDKN ILDVLEKEGC RGKIISSTFR YQLMRDCDCA LAKCGTIVLE
510 520 530 540 550
AALNQTPTIV TCLLGPIDTF LAKYIFKILM PAYSLPNIIT GSIIFPEFIG
560 570 580 590 600
GKHDFNPEEV AAAIDILAKP KSKEKQKLAC QQLLDTLMTN VVTPEECLRI
610 620
ICSQNSHLHL EKGILKNLHP RDSSV
Length:625
Mass (Da):71,007
Last modified:April 17, 2006 - v1
Checksum:i52845D7E03BE19D7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006861 Genomic DNA. Translation: BAE80993.1.
RefSeqiWP_011457775.1. NC_007899.1.
YP_515138.1. NC_007899.1.

Genome annotation databases

KEGGicfe:CF0221.
PATRICi20204013. VBIChlFel51660_0229.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006861 Genomic DNA. Translation: BAE80993.1.
RefSeqiWP_011457775.1. NC_007899.1.
YP_515138.1. NC_007899.1.

3D structure databases

ProteinModelPortaliQ255P5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi264202.CF0221.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

KEGGicfe:CF0221.
PATRICi20204013. VBIChlFel51660_0229.

Phylogenomic databases

eggNOGiCOG3952.
HOGENOMiHOG000034725.
KOiK00748.
OMAiKIIHYVC.
OrthoDBiEOG6FBWZR.

Enzyme and pathway databases

UniPathwayiUPA00359; UER00481.
BioCyciCFEL264202:GJCG-230-MONOMER.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
IPR011499. Lipid_A_biosynth.
[Graphical view]
PfamiPF07578. LAB_N. 2 hits.
PF02684. LpxB. 1 hit.
[Graphical view]
ProDomiPD339292. LAB_N. 2 hits.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Fe/C-56.

Entry informationi

Entry nameiLPXB_CHLFF
AccessioniPrimary (citable) accession number: Q255P5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 30, 2006
Last sequence update: April 17, 2006
Last modified: March 31, 2015
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.