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Q255P5

- LPXB_CHLFF

UniProt

Q255P5 - LPXB_CHLFF

Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Chlamydophila felis (strain Fe/C-56)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (18 Apr 2006)
      Previous versions | rss
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    Functioni

    Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.By similarity

    Catalytic activityi

    UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.

    Pathwayi

    GO - Molecular functioni

    1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid A biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    BioCyciCFEL264202:GJCG-230-MONOMER.
    UniPathwayiUPA00359; UER00481.

    Protein family/group databases

    CAZyiGT19. Glycosyltransferase Family 19.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lipid-A-disaccharide synthase (EC:2.4.1.182)
    Gene namesi
    Name:lpxB
    Ordered Locus Names:CF0221
    OrganismiChlamydophila felis (strain Fe/C-56)
    Taxonomic identifieri264202 [NCBI]
    Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydophila
    ProteomesiUP000001260: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 625625Lipid-A-disaccharide synthasePRO_0000255173Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi264202.CF0221.

    Structurei

    3D structure databases

    ProteinModelPortaliQ255P5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 224224UnknownAdd
    BLAST
    Regioni225 – 625401Lipid-A-disaccharide synthaseAdd
    BLAST

    Sequence similaritiesi

    In the C-terminal section; belongs to the LpxB family.Curated

    Phylogenomic databases

    eggNOGiCOG3952.
    HOGENOMiHOG000034725.
    KOiK00748.
    OMAiKIIHYVC.
    OrthoDBiEOG6FBWZR.

    Family and domain databases

    HAMAPiMF_00392. LpxB.
    InterProiIPR003835. Glyco_trans_19.
    IPR011499. Lipid_A_biosynth.
    [Graphical view]
    PfamiPF07578. LAB_N. 2 hits.
    PF02684. LpxB. 1 hit.
    [Graphical view]
    ProDomiPD339292. LAB_N. 2 hits.
    [Graphical view] [Entries sharing at least one domain]

    Sequencei

    Sequence statusi: Complete.

    Q255P5-1 [UniParc]FASTAAdd to Basket

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    MLPLHLVHVL YPIGLIANLF FGSAFTIQWF LSERRKKACV PKSFWILSSI    50
    GAVMMIAHGF IQSQFPIALL HGANLVIYFR NLNVSSSHSL SLRATLFILV 100
    VTLLLTTLPF VLGSYYYPNM QWMASPNIFH LPLPPPNIYW HIAGCIGLFT 150
    FSSRFFIQWC HLEINNRSTL PALFWLVSFI GGFLAFLYFI RTGDPVNIIS 200
    YGCGLLPSLA NLLIIYKKSR LPEFHNHSYF LSAGEPSGDI LGSDLLHNIK 250
    TCDPTIRCFG VGGPLMRKEG FEPLIHMEEF QVSGFLEVFF SIFGLFKKYR 300
    RLYKAILQEN PETVFCIDFP DFHFFLIKKL RKCGYKGKII HYVCPSIWAW 350
    RPKRKKILEK YLDTLLLILP FEKDLFINSP LKTIYLGHPL VKTISNFQYC 400
    SSWKQQLSIS DQPIVALFPG SRPGDIFRNL QVQIRAFLAS SLAQSHQILV 450
    SSCNPKYDKN ILDVLEKEGC RGKIISSTFR YQLMRDCDCA LAKCGTIVLE 500
    AALNQTPTIV TCLLGPIDTF LAKYIFKILM PAYSLPNIIT GSIIFPEFIG 550
    GKHDFNPEEV AAAIDILAKP KSKEKQKLAC QQLLDTLMTN VVTPEECLRI 600
    ICSQNSHLHL EKGILKNLHP RDSSV 625
    Length:625
    Mass (Da):71,007
    Last modified:April 18, 2006 - v1
    Checksum:i52845D7E03BE19D7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP006861 Genomic DNA. Translation: BAE80993.1.
    RefSeqiYP_515138.1. NC_007899.1.

    Genome annotation databases

    GeneIDi3958442.
    KEGGicfe:CF0221.
    PATRICi20204013. VBIChlFel51660_0229.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP006861 Genomic DNA. Translation: BAE80993.1 .
    RefSeqi YP_515138.1. NC_007899.1.

    3D structure databases

    ProteinModelPortali Q255P5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 264202.CF0221.

    Protein family/group databases

    CAZyi GT19. Glycosyltransferase Family 19.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3958442.
    KEGGi cfe:CF0221.
    PATRICi 20204013. VBIChlFel51660_0229.

    Phylogenomic databases

    eggNOGi COG3952.
    HOGENOMi HOG000034725.
    KOi K00748.
    OMAi KIIHYVC.
    OrthoDBi EOG6FBWZR.

    Enzyme and pathway databases

    UniPathwayi UPA00359 ; UER00481 .
    BioCyci CFEL264202:GJCG-230-MONOMER.

    Family and domain databases

    HAMAPi MF_00392. LpxB.
    InterProi IPR003835. Glyco_trans_19.
    IPR011499. Lipid_A_biosynth.
    [Graphical view ]
    Pfami PF07578. LAB_N. 2 hits.
    PF02684. LpxB. 1 hit.
    [Graphical view ]
    ProDomi PD339292. LAB_N. 2 hits.
    [Graphical view ] [Entries sharing at least one domain ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Fe/C-56.

    Entry informationi

    Entry nameiLPXB_CHLFF
    AccessioniPrimary (citable) accession number: Q255P5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: April 18, 2006
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3