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Protein

Serine/threonine-protein kinase PknD

Gene

pknD

Organism
Chlamydophila felis (strain Fe/C-56)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Together with the serine/threonine kinase Pkn1, may play a role in the specific interactions with host proteins during intracellular growth.UniRule annotation

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei33 – 331ATPUniRule annotation
Active sitei138 – 1381Proton acceptorUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 189ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. protein serine/threonine kinase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCFEL264202:GJCG-349-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase PknDUniRule annotation (EC:2.7.11.1UniRule annotation)
Gene namesi
Name:pknDUniRule annotation
Ordered Locus Names:CF0334
OrganismiChlamydophila felis (strain Fe/C-56)
Taxonomic identifieri264202 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydophila
ProteomesiUP000001260: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 933933Serine/threonine-protein kinase PknDPRO_0000239301Add
BLAST

Post-translational modificationi

Autophosphorylated on serine and threonine residues.UniRule annotation

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi264202.CF0334.

Structurei

3D structure databases

ProteinModelPortaliQ255D2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 291288Protein kinaseUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.UniRule annotation
Contains 1 protein kinase domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000034686.
KOiK08884.
OrthoDBiEOG6W45P7.

Family and domain databases

HAMAPiMF_01957. PknD_kinase.
InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR023507. Ser/Thr_kinase_PknD.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q255D2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQRYDIIRMI GKGGMGEVYL AYDPVCSRKV ALKRIREDLS DNELLKKRFL
60 70 80 90 100
REAKIAADLV HPGVVPVFTI CSDSDPVYYT MPYIEGYTLK SLLKSVWQCD
110 120 130 140 150
SLPKDLAEQT SVGTFLSIFH KICSTVEYVH SRGILHRDLK PDNILLGLFS
160 170 180 190 200
EVVILDWGAA LSKEMQEEVL LDIDIPVTGS MFSNMTIPGK IVGTPDYMAP
210 220 230 240 250
ERLRGTPASE STDIYALGVI LYQMLTLSFP YRNKKGKKIS FRHQISSPEE
260 270 280 290 300
IAPHREIPPF LSQVAMKALA ADPKVRYASV KELKDDIEQH LQGSPEWTPK
310 320 330 340 350
TILHTQKAEC WKLRESILLS KYFPMLGVSP ALWYSLAISK IESFSEVRLE
360 370 380 390 400
YTLLRKGLED GFGILLPPSE GVDHGDFYHG YGFWLHIKNS VFSVSLVKNG
410 420 430 440 450
LEIRKTSRPI KENKEKFFIA LEKQNHRLSL IIDHVVWMIH MDYLPGRGGR
460 470 480 490 500
IGVIIQDVTD VCGNIVVLES SGSLQVSCLA VPDAFLNEKL YDRAITFYRR
510 520 530 540 550
IAESFPGRKE GYEAQFRIGI ALLEKASESG DSEGFTQALG KFEILHNSVA
560 570 580 590 600
APLEYLGKAL VYQRLGEYNE EVKSLLLALK RYCQCPEISR IRDHIVYRLH
610 620 630 640 650
ETLYSNHRLS LVFMLLALHI APESINATEE EYFVKNLHGK IQDTLFCNLD
660 670 680 690 700
LSPIDFRSSK MELLLSYWSG FTPFLPGLFQ KYWDLKDYRA LADVFYVAAD
710 720 730 740 750
LGNREFLEMY SDLVRENICS TTCTEDIVEF LPHQLEHFFS GVRAISLHEP
760 770 780 790 800
LEKVFAHIEI LDPVLILYLF DLFAKDALIH HRGELILSAI TLIEKYVSSQ
810 820 830 840 850
QYYEHLLPCE VLAYLWMKDE KKVYNLLCNN YEESLWLDDR SPAFVLYGCW
860 870 880 890 900
LALVEDSSLS YLHLSGCRED ALYPRALIGG FCSPLGICEN QLSYQERRKL
910 920 930
LLQKFIFFHC LGMNEERDNC TVAYDLLSIE RSL
Length:933
Mass (Da):106,799
Last modified:June 13, 2006 - v2
Checksum:i17E45CDA3148658A
GO

Sequence cautioni

The sequence BAE81106.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006861 Genomic DNA. Translation: BAE81106.1. Different initiation.
RefSeqiYP_515251.2. NC_007899.1.

Genome annotation databases

GeneIDi3958545.
KEGGicfe:CF0334.
PATRICi20204258. VBIChlFel51660_0345.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006861 Genomic DNA. Translation: BAE81106.1. Different initiation.
RefSeqiYP_515251.2. NC_007899.1.

3D structure databases

ProteinModelPortaliQ255D2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi264202.CF0334.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3958545.
KEGGicfe:CF0334.
PATRICi20204258. VBIChlFel51660_0345.

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000034686.
KOiK08884.
OrthoDBiEOG6W45P7.

Enzyme and pathway databases

BioCyciCFEL264202:GJCG-349-MONOMER.

Family and domain databases

HAMAPiMF_01957. PknD_kinase.
InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR023507. Ser/Thr_kinase_PknD.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Fe/C-56.

Entry informationi

Entry nameiPKND_CHLFF
AccessioniPrimary (citable) accession number: Q255D2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: June 13, 2006
Last modified: January 7, 2015
This is version 53 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.