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Q25566

- UMPS_NAEGR

UniProt

Q25566 - UMPS_NAEGR

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Protein

Uridine 5'-monophosphate synthase

Gene

UMP

Organism
Naegleria gruberi (Amoeba)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate.
Orotidine 5'-phosphate = UMP + CO2.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei322 – 3221By similarity

GO - Molecular functioni

  1. orotate phosphoribosyltransferase activity Source: UniProtKB-EC
  2. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-EC

GO - Biological processi

  1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
  2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Glycosyltransferase, Lyase, Transferase

Keywords - Biological processi

Pyrimidine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00070; UER00119.
UPA00070; UER00120.

Names & Taxonomyi

Protein namesi
Recommended name:
Uridine 5'-monophosphate synthase
Short name:
UMP synthase
Including the following 2 domains:
Orotate phosphoribosyltransferase (EC:2.4.2.10)
Short name:
OPRTase
Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
Alternative name(s):
OMPdecase
Gene namesi
Name:UMP
OrganismiNaegleria gruberi (Amoeba)
Taxonomic identifieri5762 [NCBI]
Taxonomic lineageiEukaryotaHeteroloboseaSchizopyrenidaVahlkampfiidaeNaegleria

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 494494Uridine 5'-monophosphate synthasePRO_0000139655Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ25566.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

In the N-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.Curated
In the C-terminal section; belongs to the OMP decarboxylase family.Curated

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
3.40.50.2020. 1 hit.
HAMAPiMF_01208. PyrE.
InterProiIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR001754. OMPdeCOase_dom.
IPR023031. OPRT.
IPR029057. PRTase-like.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
SSF53271. SSF53271. 1 hit.
TIGRFAMsiTIGR01740. pyrF. 1 hit.
PROSITEiPS00103. PUR_PYR_PR_TRANSFER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q25566-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
METTTIDIQA LKKELVLDLI QIGALKFGRF TLKSGIVSPF YVDLRIIGPK
60 70 80 90 100
MLRQFSVLLY HVMTVKGLTN MEKRVICGVP YSALTFSSCM SMTYDLPMVI
110 120 130 140 150
CRKERKQYGT GNMVEGIYTK NETNCILIED VITSGASIVE TAEKLENEGL
160 170 180 190 200
LVTDALVFLT REQLPLTNGM HILKKGEKVY NVHPCLTMTE VTQVLLDEGK
210 220 230 240 250
MSQEQREDIL QFIGTNTFSE TKTTAVPQKK KELTFTERAE LTNNEFSKKL
260 270 280 290 300
FKLMEEKQTN LCVAADITSK DDLLKLADET GPEICMLKTH IDTLDDQPDE
310 320 330 340 350
QFTQQLKELA KKHNFLIFED RKLADIGQVV KQQYARGPFK IAQWSDLCNS
360 370 380 390 400
HLVSGGSATV KALKESLKEE NITEPRGLLL IAQMSTEGAT TGESTKQEAL
410 420 430 440 450
KVALENPDFV SGFICQSKLR DDLDQFLYCT PGVRLDVKGD SLGQQYNSPE
460 470 480 490
YVVCEKKCDV IIVGRGIYHD KERQNAAKLY RKLGWEAYQK RIQQ
Length:494
Mass (Da):55,809
Last modified:November 1, 1996 - v1
Checksum:iECE04004A92B0080
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08073 Genomic DNA. Translation: AAA29385.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08073 Genomic DNA. Translation: AAA29385.1 .

3D structure databases

ProteinModelPortali Q25566.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00070 ; UER00119 .
UPA00070 ; UER00120 .

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
3.40.50.2020. 1 hit.
HAMAPi MF_01208. PyrE.
InterProi IPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR001754. OMPdeCOase_dom.
IPR023031. OPRT.
IPR029057. PRTase-like.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00215. OMPdecase. 1 hit.
[Graphical view ]
SMARTi SM00934. OMPdecase. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
SSF53271. SSF53271. 1 hit.
TIGRFAMsi TIGR01740. pyrF. 1 hit.
PROSITEi PS00103. PUR_PYR_PR_TRANSFER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A bifunctional UMP synthase gene from Naegleria gruberi expresses OMP decarboxylase activity in bacteria and in yeast."
    Remillard S.P., Lai E.Y., Fulton C.
    Submitted (FEB-1993) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: NEG.

Entry informationi

Entry nameiUMPS_NAEGR
AccessioniPrimary (citable) accession number: Q25566
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: October 1, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3