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Q25537

- G6PD_SARBU

UniProt

Q25537 - G6PD_SARBU

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Protein

Glucose-6-phosphate 1-dehydrogenase

Gene

ZW

Organism
Sarcophaga bullata (Grey flesh fly) (Neobellieria bullata)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis (By similarity).By similarity

Catalytic activityi

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei21 – 211NADP 1By similarity
Binding sitei120 – 1201NADP 1; via carbonyl oxygenBy similarity
Binding sitei120 – 1201SubstratePROSITE-ProRule annotation

GO - Molecular functioni

  1. glucose-6-phosphate dehydrogenase activity Source: UniProtKB-EC
  2. NADP binding Source: InterPro

GO - Biological processi

  1. pentose-phosphate shunt Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

UniPathwayiUPA00115; UER00408.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate 1-dehydrogenase (EC:1.1.1.49)
Short name:
G6PD
Alternative name(s):
Zwischenferment
Gene namesi
Name:ZW
OrganismiSarcophaga bullata (Grey flesh fly) (Neobellieria bullata)
Taxonomic identifieri7385 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaOestroideaSarcophagidaeNeobellieria

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – ›153›153Glucose-6-phosphate 1-dehydrogenasePRO_0000068096Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ25537.
SMRiQ25537. Positions 1-153.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni150 – 1534Substrate bindingBy similarity

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR001282. G6P_DH.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF00479. G6PD_N. 1 hit.
[Graphical view]
PRINTSiPR00079. G6PDHDRGNASE.

Sequencei

Sequence statusi: Fragment.

Q25537-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
LWWLYRDNLL PKPTKFCGYA RSKLTTADIR KACEKFMKVQ PHEQQRYEEF
60 70 80 90 100
WELNHYVSGS YDGRLGFEML QQQMEIMENK GVANRVFYLA LPPSVFNSVT
110 120 130 140 150
VRIKEICLSK KGWNRVIIEK PFGRDDVTSK QLSDHLASLF DEEQIYRIDH

YLG
Length:153
Mass (Da):18,158
Last modified:November 1, 1996 - v1
Checksum:i174FD398F3E26506
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11
Non-terminal residuei153 – 1531

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09037 mRNA. Translation: AAB02781.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09037 mRNA. Translation: AAB02781.1 .

3D structure databases

ProteinModelPortali Q25537.
SMRi Q25537. Positions 1-153.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00115 ; UER00408 .

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR001282. G6P_DH.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR23429. PTHR23429. 1 hit.
Pfami PF00479. G6PD_N. 1 hit.
[Graphical view ]
PRINTSi PR00079. G6PDHDRGNASE.
ProtoNeti Search...

Publicationsi

  1. "Phylogenetic utility of partial DNA sequences of G6PDH at different taxonomic levels in Hexapoda with emphasis on Diptera."
    Soto-Adames F.N., Robertson H.M., Berlocher S.H.
    Ann. Entomol. Soc. Am. 87:723-736(1994)
    [AGRICOLA] [Europe PMC]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiG6PD_SARBU
AccessioniPrimary (citable) accession number: Q25537
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: October 1, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3