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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Chlamydia felis (strain Fe/C-56) (Chlamydophila felis)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei604ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCFEL264202:G1G29-400-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:CF0391
OrganismiChlamydia felis (strain Fe/C-56) (Chlamydophila felis)
Taxonomic identifieri264202 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi
  • UP000001260 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000093211 – 820Leucine--tRNA ligaseAdd BLAST820

Proteomic databases

PRIDEiQ254X5

Interactioni

Protein-protein interaction databases

STRINGi264202.CF0391

Structurei

3D structure databases

ProteinModelPortaliQ254X5
SMRiQ254X5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi40 – 51"HIGH" regionAdd BLAST12
Motifi601 – 605"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
HOGENOMiHOG000200748
KOiK01869
OMAiTFMVLAP

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF13603 tRNA-synt_1_2, 1 hit
PF09334 tRNA-synt_1g, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q254X5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRYDPSLIEK KWQEFWKEHK SFKANEADDK PKYYVLDMFP YPSGAGLHVG
60 70 80 90 100
HLIGYTATDI VARYKRAKGF SVLHPMGWDS FGLPAEQYAV RTGTHPRETT
110 120 130 140 150
QKNIENFRKQ LSAMGFSYDE GREFATSDPE YYRWTQKLFL LLYEKGLAYM
160 170 180 190 200
ADMAVNYCPE LGTVLSNEEV ENGLSIEGGY PVERRMLRQW ILRITAYSDQ
210 220 230 240 250
LLEGLEGLDW PENVKQLQRN WIGKSEGALV RFKVNNQNFL EVFTTRPDTL
260 270 280 290 300
CGVSFLVIAP EHPEVGQLIA EDRREEVEAY ICRAQSKSER DRISESKIKS
310 320 330 340 350
GVFTGTYAKH PITGADIPIW VSDYVILGYG SGVVMGVPAH DERDREFAET
360 370 380 390 400
FSLPIYEVLD TDGYCIHSNH GDFLLDGLWG REAQDYVIAY LQKKNLGESK
410 420 430 440 450
VAYKLRDWLF SRQRYWGEPI PIIHFEDGTC RPLEDDELPL LPPEIQDYRP
460 470 480 490 500
EGFGQGPLAK VKEWVDIHDK KTNRQGRRET HTMPQWAGSC WYYLRFCDAL
510 520 530 540 550
NSQAPWSNEK EKYWMPVDLY IGGAEHAVLH LLYSRFWHRV FYDAGMVSTP
560 570 580 590 600
EPFKKLINQG LVLATSYRIP GKGYVYPEDA HEDNGVWMST SGEELEVRQE
610 620 630 640 650
KMSKSKLNGV DPQILIEEFG ADALRMYAMF SGPLDKNKLW CNQGVSGCRR
660 670 680 690 700
FLNRFYELVT SSLVQDIDDP KGMYLAHRLV HRVGEDIEKM SLNTIPSSFM
710 720 730 740 750
EFINEFVKLD IYPKSALAMV VRALAPIAPH ISEELWTILG NAPGIDQAGW
760 770 780 790 800
PEVDPKYLED TSVTFVIQVN GKLRARLDIS KNAAREEVLS LAREAVSRYL
810 820
EDKEVKKEIF VPNRLVNFVL
Length:820
Mass (Da):94,247
Last modified:April 18, 2006 - v1
Checksum:iEAC547EDE26B1A2C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006861 Genomic DNA Translation: BAE81163.1
RefSeqiWP_011457943.1, NC_007899.1

Genome annotation databases

KEGGicfe:CF0391

Similar proteinsi

Entry informationi

Entry nameiSYL_CHLFF
AccessioniPrimary (citable) accession number: Q254X5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 18, 2006
Last modified: May 23, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health