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Q254X5

- SYL_CHLFF

UniProt

Q254X5 - SYL_CHLFF

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Chlamydophila felis (strain Fe/C-56)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei604 – 6041ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCFEL264202:GJCG-407-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:CF0391
OrganismiChlamydophila felis (strain Fe/C-56)
Taxonomic identifieri264202 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydophila
ProteomesiUP000001260: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 820820Leucine--tRNA ligasePRO_1000009321Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi264202.CF0391.

Structurei

3D structure databases

ProteinModelPortaliQ254X5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi40 – 5112"HIGH" regionAdd
BLAST
Motifi601 – 6055"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q254X5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRYDPSLIEK KWQEFWKEHK SFKANEADDK PKYYVLDMFP YPSGAGLHVG
60 70 80 90 100
HLIGYTATDI VARYKRAKGF SVLHPMGWDS FGLPAEQYAV RTGTHPRETT
110 120 130 140 150
QKNIENFRKQ LSAMGFSYDE GREFATSDPE YYRWTQKLFL LLYEKGLAYM
160 170 180 190 200
ADMAVNYCPE LGTVLSNEEV ENGLSIEGGY PVERRMLRQW ILRITAYSDQ
210 220 230 240 250
LLEGLEGLDW PENVKQLQRN WIGKSEGALV RFKVNNQNFL EVFTTRPDTL
260 270 280 290 300
CGVSFLVIAP EHPEVGQLIA EDRREEVEAY ICRAQSKSER DRISESKIKS
310 320 330 340 350
GVFTGTYAKH PITGADIPIW VSDYVILGYG SGVVMGVPAH DERDREFAET
360 370 380 390 400
FSLPIYEVLD TDGYCIHSNH GDFLLDGLWG REAQDYVIAY LQKKNLGESK
410 420 430 440 450
VAYKLRDWLF SRQRYWGEPI PIIHFEDGTC RPLEDDELPL LPPEIQDYRP
460 470 480 490 500
EGFGQGPLAK VKEWVDIHDK KTNRQGRRET HTMPQWAGSC WYYLRFCDAL
510 520 530 540 550
NSQAPWSNEK EKYWMPVDLY IGGAEHAVLH LLYSRFWHRV FYDAGMVSTP
560 570 580 590 600
EPFKKLINQG LVLATSYRIP GKGYVYPEDA HEDNGVWMST SGEELEVRQE
610 620 630 640 650
KMSKSKLNGV DPQILIEEFG ADALRMYAMF SGPLDKNKLW CNQGVSGCRR
660 670 680 690 700
FLNRFYELVT SSLVQDIDDP KGMYLAHRLV HRVGEDIEKM SLNTIPSSFM
710 720 730 740 750
EFINEFVKLD IYPKSALAMV VRALAPIAPH ISEELWTILG NAPGIDQAGW
760 770 780 790 800
PEVDPKYLED TSVTFVIQVN GKLRARLDIS KNAAREEVLS LAREAVSRYL
810 820
EDKEVKKEIF VPNRLVNFVL
Length:820
Mass (Da):94,247
Last modified:April 18, 2006 - v1
Checksum:iEAC547EDE26B1A2C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006861 Genomic DNA. Translation: BAE81163.1.
RefSeqiYP_515308.1. NC_007899.1.

Genome annotation databases

GeneIDi3958432.
KEGGicfe:CF0391.
PATRICi20204382. VBIChlFel51660_0406.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006861 Genomic DNA. Translation: BAE81163.1 .
RefSeqi YP_515308.1. NC_007899.1.

3D structure databases

ProteinModelPortali Q254X5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 264202.CF0391.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3958432.
KEGGi cfe:CF0391.
PATRICi 20204382. VBIChlFel51660_0406.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci CFEL264202:GJCG-407-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Fe/C-56.

Entry informationi

Entry nameiSYL_CHLFF
AccessioniPrimary (citable) accession number: Q254X5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 18, 2006
Last modified: October 29, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3