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Q254T2

- Q254T2_CHLFF

UniProt

Q254T2 - Q254T2_CHLFF

Protein

Kynureninase

Gene

kynU

Organism
Chlamydophila felis (strain Fe/C-56)
Status
Unreviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (18 Apr 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.UniRule annotation

    Catalytic activityi

    L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.UniRule annotation
    L-kynurenine + H2O = anthranilate + L-alanine.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei106 – 1061Pyridoxal phosphate; via amide nitrogenUniRule annotation
    Binding sitei107 – 1071Pyridoxal phosphateUniRule annotation
    Binding sitei219 – 2191Pyridoxal phosphateUniRule annotation
    Binding sitei222 – 2221Pyridoxal phosphateUniRule annotation
    Binding sitei244 – 2441Pyridoxal phosphateUniRule annotation
    Binding sitei274 – 2741Pyridoxal phosphateUniRule annotation
    Binding sitei304 – 3041Pyridoxal phosphateUniRule annotation

    GO - Molecular functioni

    1. kynureninase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' NAD biosynthetic process from tryptophan Source: UniProtKB-HAMAP
    2. anthranilate metabolic process Source: UniProtKB-HAMAP
    3. L-kynurenine catabolic process Source: UniProtKB-UniPathway
    4. quinolinate biosynthetic process Source: UniProtKB-HAMAP
    5. tryptophan catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    HydrolaseUniRule annotation

    Keywords - Biological processi

    Pyridine nucleotide biosynthesisUniRule annotation

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotation

    Enzyme and pathway databases

    BioCyciCFEL264202:GJCG-454-MONOMER.
    UniPathwayiUPA00253; UER00329.
    UPA00334; UER00455.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    KynureninaseUniRule annotation (EC:3.7.1.3UniRule annotation)
    Alternative name(s):
    L-kynurenine hydrolaseUniRule annotation
    Gene namesi
    Name:kynUUniRule annotationImported
    Ordered Locus Names:CF0434Imported
    OrganismiChlamydophila felis (strain Fe/C-56)Imported
    Taxonomic identifieri264202 [NCBI]
    Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydophila
    ProteomesiUP000001260: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: InterPro

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei245 – 2451N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi264202.CF0434.

    Structurei

    3D structure databases

    ProteinModelPortaliQ254T2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni134 – 1374Pyridoxal phosphate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the kynureninase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG3844.
    HOGENOMiHOG000242438.
    KOiK01556.
    OMAiVWDLAHS.
    OrthoDBiEOG6N67XP.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    HAMAPiMF_01970. Kynureninase.
    InterProiIPR000192. Aminotrans_V/Cys_dSase.
    IPR010111. Kynureninase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PANTHERiPTHR14084. PTHR14084. 1 hit.
    PfamiPF00266. Aminotran_5. 1 hit.
    [Graphical view]
    PIRSFiPIRSF038800. KYNU. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR01814. kynureninase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q254T2-1 [UniParc]FASTAAdd to Basket

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    MNEILKNYQK KATQLDEQDC LKHLRARFSL PKDPNAIYFC NNSLGLPAVS    50
    AFTKIEELLQ CWSDVGVNGW FEGTGNWYRS FDRPLRQPLS KILGAEYEEV 100
    IVMNSLTMNL HLLLVSFYRP TDTRYKILIE GPTFPSDLYA IKSHLSFHGR 150
    NPDEALIILK PRADEDLLRY EDFQQILKEQ GESIALVFMN CVNFLTGQVL 200
    EVEAITHLAK EKGCIVGCDL AHAAGNIPLK LHEWGVDFAL GCSYKYLCGG 250
    PGGPGIAYVH KSHHDEQLPR FSGWWGNDPE TRFQMQLQPE FVPYGGAYSW 300
    QVSTPSILSL MPLLATLEVF EEAGMERVRN KSKQMTAFLL ELLELAPSSY 350
    FEIITPRDPE LRGSQLSVRI QQHSEEVLQK LEAQRITCDS RPPDIIRVTP 400
    TPLYNTFSEI YQFTCKLLEV LEIKL 425
    Length:425
    Mass (Da):48,438
    Last modified:April 18, 2006 - v1
    Checksum:iB7A83B4A7BE08193
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP006861 Genomic DNA. Translation: BAE81206.1.
    RefSeqiYP_515351.1. NC_007899.1.

    Genome annotation databases

    GeneIDi3958709.
    KEGGicfe:CF0434.
    PATRICi20204482. VBIChlFel51660_0452.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP006861 Genomic DNA. Translation: BAE81206.1 .
    RefSeqi YP_515351.1. NC_007899.1.

    3D structure databases

    ProteinModelPortali Q254T2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 264202.CF0434.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3958709.
    KEGGi cfe:CF0434.
    PATRICi 20204482. VBIChlFel51660_0452.

    Phylogenomic databases

    eggNOGi COG3844.
    HOGENOMi HOG000242438.
    KOi K01556.
    OMAi VWDLAHS.
    OrthoDBi EOG6N67XP.

    Enzyme and pathway databases

    UniPathwayi UPA00253 ; UER00329 .
    UPA00334 ; UER00455 .
    BioCyci CFEL264202:GJCG-454-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    HAMAPi MF_01970. Kynureninase.
    InterProi IPR000192. Aminotrans_V/Cys_dSase.
    IPR010111. Kynureninase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    PANTHERi PTHR14084. PTHR14084. 1 hit.
    Pfami PF00266. Aminotran_5. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF038800. KYNU. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR01814. kynureninase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Fe/C-56Imported.

    Entry informationi

    Entry nameiQ254T2_CHLFF
    AccessioniPrimary (citable) accession number: Q254T2
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 18, 2006
    Last sequence update: April 18, 2006
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3