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Q254T2

- Q254T2_CHLFF

UniProt

Q254T2 - Q254T2_CHLFF

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Protein
Kynureninase
Gene
kynU, CF0434
Organism
Chlamydophila felis (strain Fe/C-56)
Status
Unreviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively By similarity.UniRule annotation

Catalytic activityi

L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.UniRule annotation
L-kynurenine + H2O = anthranilate + L-alanine.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei106 – 1061Pyridoxal phosphate; via amide nitrogen By similarityUniRule annotation
Binding sitei107 – 1071Pyridoxal phosphate By similarityUniRule annotation
Binding sitei219 – 2191Pyridoxal phosphate By similarityUniRule annotation
Binding sitei222 – 2221Pyridoxal phosphate By similarityUniRule annotation
Binding sitei244 – 2441Pyridoxal phosphate By similarityUniRule annotation
Binding sitei274 – 2741Pyridoxal phosphate By similarityUniRule annotation
Binding sitei304 – 3041Pyridoxal phosphate By similarityUniRule annotation

GO - Molecular functioni

  1. kynureninase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' NAD biosynthetic process from tryptophan Source: UniProtKB-HAMAP
  2. L-kynurenine catabolic process Source: UniProtKB-UniPathway
  3. anthranilate metabolic process Source: UniProtKB-HAMAP
  4. quinolinate biosynthetic process Source: UniProtKB-HAMAP
  5. tryptophan catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotation

Keywords - Biological processi

Pyridine nucleotide biosynthesisUniRule annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Enzyme and pathway databases

BioCyciCFEL264202:GJCG-454-MONOMER.
UniPathwayiUPA00253; UER00329.
UPA00334; UER00455.

Names & Taxonomyi

Protein namesi
Recommended name:
KynureninaseUniRule annotation (EC:3.7.1.3UniRule annotation)
Alternative name(s):
L-kynurenine hydrolase
Gene namesi
Name:kynUUniRule annotationImported
Ordered Locus Names:CF0434Imported
OrganismiChlamydophila felis (strain Fe/C-56)Imported
Taxonomic identifieri264202 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydophila
ProteomesiUP000001260: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei245 – 2451N6-(pyridoxal phosphate)lysine By similarityUniRule annotation

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi264202.CF0434.

Structurei

3D structure databases

ProteinModelPortaliQ254T2.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni134 – 1374Pyridoxal phosphate binding By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG3844.
HOGENOMiHOG000242438.
KOiK01556.
OMAiVWDLAHS.
OrthoDBiEOG6N67XP.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_01970. Kynureninase.
InterProiIPR000192. Aminotrans_V/Cys_dSase.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR14084. PTHR14084. 1 hit.
PfamiPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFiPIRSF038800. KYNU. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01814. kynureninase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q254T2-1 [UniParc]FASTAAdd to Basket

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MNEILKNYQK KATQLDEQDC LKHLRARFSL PKDPNAIYFC NNSLGLPAVS    50
AFTKIEELLQ CWSDVGVNGW FEGTGNWYRS FDRPLRQPLS KILGAEYEEV 100
IVMNSLTMNL HLLLVSFYRP TDTRYKILIE GPTFPSDLYA IKSHLSFHGR 150
NPDEALIILK PRADEDLLRY EDFQQILKEQ GESIALVFMN CVNFLTGQVL 200
EVEAITHLAK EKGCIVGCDL AHAAGNIPLK LHEWGVDFAL GCSYKYLCGG 250
PGGPGIAYVH KSHHDEQLPR FSGWWGNDPE TRFQMQLQPE FVPYGGAYSW 300
QVSTPSILSL MPLLATLEVF EEAGMERVRN KSKQMTAFLL ELLELAPSSY 350
FEIITPRDPE LRGSQLSVRI QQHSEEVLQK LEAQRITCDS RPPDIIRVTP 400
TPLYNTFSEI YQFTCKLLEV LEIKL 425
Length:425
Mass (Da):48,438
Last modified:April 18, 2006 - v1
Checksum:iB7A83B4A7BE08193
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006861 Genomic DNA. Translation: BAE81206.1.
RefSeqiYP_515351.1. NC_007899.1.

Genome annotation databases

GeneIDi3958709.
KEGGicfe:CF0434.
PATRICi20204482. VBIChlFel51660_0452.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006861 Genomic DNA. Translation: BAE81206.1 .
RefSeqi YP_515351.1. NC_007899.1.

3D structure databases

ProteinModelPortali Q254T2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 264202.CF0434.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3958709.
KEGGi cfe:CF0434.
PATRICi 20204482. VBIChlFel51660_0452.

Phylogenomic databases

eggNOGi COG3844.
HOGENOMi HOG000242438.
KOi K01556.
OMAi VWDLAHS.
OrthoDBi EOG6N67XP.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00329 .
UPA00334 ; UER00455 .
BioCyci CFEL264202:GJCG-454-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPi MF_01970. Kynureninase.
InterProi IPR000192. Aminotrans_V/Cys_dSase.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR14084. PTHR14084. 1 hit.
Pfami PF00266. Aminotran_5. 1 hit.
[Graphical view ]
PIRSFi PIRSF038800. KYNU. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR01814. kynureninase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Fe/C-56Imported.

Entry informationi

Entry nameiQ254T2_CHLFF
AccessioniPrimary (citable) accession number: Q254T2
Entry historyi
Integrated into UniProtKB/TrEMBL: April 18, 2006
Last sequence update: April 18, 2006
Last modified: July 9, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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